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Article

Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites

  • Authors:
    • Jian Cao
    • Yuhong Man
    • Lisen Li
  • View Affiliations / Copyright

    Affiliations: Department of Hand Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
  • Pages: 428-432
    |
    Published online on: March 1, 2013
       https://doi.org/10.3892/br.2013.70
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Abstract

Electrical stimulation may improve the proliferation of animal cells. In the present study, osteoblasts were cultured on electroactive aniline pentamer (AP)̸poly(lactic‑co-glycolic acid) (PLGA) copolymer composites, on which electric pulse was imposed. The combination of polymer and electric pulse enhanced the osteogenic differentiation of the osteoblasts, characterized by the upregulated expression of bone morphogenetic protein (BMP)‑2, collagen I and osteonectin and the phosphorylation of Samd4, in contrast to polymer or electrical pulse alone. This action occurred in a polymer content‑dependent manner. Therefore, the action of the electric pulse, assisted by the electroactive polymer implant, may be promising in the expedition of injured bone repair.
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Copy and paste a formatted citation
Spandidos Publications style
Cao J, Man Y and Li L: Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites. Biomed Rep 1: 428-432, 2013.
APA
Cao, J., Man, Y., & Li, L. (2013). Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites. Biomedical Reports, 1, 428-432. https://doi.org/10.3892/br.2013.70
MLA
Cao, J., Man, Y., Li, L."Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites". Biomedical Reports 1.3 (2013): 428-432.
Chicago
Cao, J., Man, Y., Li, L."Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites". Biomedical Reports 1, no. 3 (2013): 428-432. https://doi.org/10.3892/br.2013.70
Copy and paste a formatted citation
x
Spandidos Publications style
Cao J, Man Y and Li L: Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites. Biomed Rep 1: 428-432, 2013.
APA
Cao, J., Man, Y., & Li, L. (2013). Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites. Biomedical Reports, 1, 428-432. https://doi.org/10.3892/br.2013.70
MLA
Cao, J., Man, Y., Li, L."Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites". Biomedical Reports 1.3 (2013): 428-432.
Chicago
Cao, J., Man, Y., Li, L."Electrical stimuli improve osteogenic differentiation mediated by aniline pentamer and PLGA nanocomposites". Biomedical Reports 1, no. 3 (2013): 428-432. https://doi.org/10.3892/br.2013.70
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