bioinformatics analysis of the structure and function of NADPH‑cytochrome p450 reductase of Plasmodium vivax

Fan,Zhigang; Li,Kaijie; Zhang,Lingmin; Chen,Fan; Wu,Qiang; Li,Na; Zhong,Saifeng; Lin,Guifen; Yan,Guogang

doi:10.3892/br.2013.71

May-June 2013 Volume 1 Issue 3

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May-June 2013 Volume 1 Issue 3

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Article

bioinformatics analysis of the structure and function of NADPH‑cytochrome p450 reductase of Plasmodium vivax

Authors:
- Zhigang Fan
- Kaijie Li
- Lingmin Zhang
- Fan Chen
- Qiang Wu
- Na Li
- Saifeng Zhong
- Guifen Lin
- Guogang Yan
View Affiliations / Copyright

Affiliations: School of Tropical and Laboratory Medicine, Hainan Medical College, Haikou 571199, P.R. China, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, P.R. China, Department of Parasitology, Medical College, Jinan University, Guangzhou 510623, P.R. China, Department of Biochemistry and Molecular Biology, Medical School, Wuhan University, Wuhan 430072, P.R. China, School of Nursing, Hainan Medical College, Haikou 571199, P.R. China
Pages: 425-427
|
Published online on: March 4, 2013

https://doi.org/10.3892/br.2013.71
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Abstract

The structure of NADPH‑cytochrome p450 reductase (CPR) of Plasmodium falciparum (P. falciparum or Pf) has been determined using bioinformatics analysis. However, that of Plasmodium vivax (P. vivax or Pv) has not yet been determined. This study aimed to analyze the structure and function of PvCPR using bioinformatics analysis. The results demonstrated that PvCPR was an unstable and alkaline enzyme located in the cytoplasm of parasites with a signal peptide. It possessed seven types of signal sites and eight protein‑protein binding sites, and had a tertiary structure resembling a forceps with a single wing, which differed from that of PfCPR. It also had nine linear B‑cell epitopes and 10 antigenicity sites, which were not homologous with the amino acid sequence of Homo sapiens (H. sapiens or Hs) CPR and six fragments that were similar to fragments of immune‑related protein sequences from H. sapiens. Therefore, the function of PvCPR may be different from that of PfCPR, and PvCPR may participate in the immune escape of P. vivax.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

bioinformatics analysis of the structure and function of NADPH‑cytochrome p450 reductase of Plasmodium vivax

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Abstract

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