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Article

Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice

  • Authors:
    • Yosuke Inui
    • Hideki Mochida
    • Fumiko Yamairi
    • Miyoko Okada
    • Junji Ishida
    • Akiyoshi Fukamizu
    • Kenji Arakawa
  • View Affiliations / Copyright

    Affiliations: Pharmacology Research Laboratories II, Mitsubishi Tanabe Pharma Corporation, Toda, Saitama 335‑8505, Japan, Advanced Medical Research Laboratory, Mitsubishi Tanabe Pharma Corporation, Toda, Saitama 335‑8505, Japan, Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation, Kisarazu, Chiba 292-0818, Japan, Life Science Center, Tsukuba Advanced Research Alliance, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan
  • Pages: 359-364
    |
    Published online on: March 7, 2013
       https://doi.org/10.3892/br.2013.74
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Abstract

Renal dysfunction is accelerated by various factors such as hypertension, aging and diabetes. Glomerular hyperfiltration, considered one of the major risk factors leading to diabetic nephropathy, is often encountered in diabetic patients. However, the interrelationship of these risk factors during the course and development of renal dysfunction has not been fully elucidated. In this study, the effects of aging and uninephrectomy (UNx)‑induced hyperfiltration on renal changes were investigated in Tsukuba hypertensive mice (THM) carrying both human renin and angiotensinogen genes. In THM, the urinary albumin/creatinine (Alb/Cr) ratio was elevated with age without a concomitant increase in the plasma Cr concentration. Moreover, the urinary neutrophil gelatinase‑associated lipocalin/Cr (NGAL/Cr) ratio, the renal monocyte chemoattractant protein‑1 (MCP‑1) mRNA expression and the renal collagen type I α 2 (COL1A2) mRNA expression were also increased with age. Age‑related albuminuria in THM is likely caused by renal tubular damage, enhanced inflammatory response and tubulointerstitial fibrosis. Furthermore, following UNx, the urinary Alb̸Cr ratio and the plasma Cr concentration were increased in THM. The urinary NGAL/Cr ratio and the renal MCP‑1 and COL1A2 mRNA expression were not affected by UNx. These results suggested that UNx‑induced albuminuria in THM was caused by glomerular dysfunction, rather than renal tubular injury. In conclusion, this study demonstrated for the first time the effects of aging and UNx on renal changes in THM. These findings strongly reinforce the significance of applying a diversity of therapeutic approaches to the management of renal dysfunction.
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Copy and paste a formatted citation
Spandidos Publications style
Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A and Arakawa K: Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomed Rep 1: 359-364, 2013.
APA
Inui, Y., Mochida, H., Yamairi, F., Okada, M., Ishida, J., Fukamizu, A., & Arakawa, K. (2013). Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomedical Reports, 1, 359-364. https://doi.org/10.3892/br.2013.74
MLA
Inui, Y., Mochida, H., Yamairi, F., Okada, M., Ishida, J., Fukamizu, A., Arakawa, K."Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice". Biomedical Reports 1.3 (2013): 359-364.
Chicago
Inui, Y., Mochida, H., Yamairi, F., Okada, M., Ishida, J., Fukamizu, A., Arakawa, K."Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice". Biomedical Reports 1, no. 3 (2013): 359-364. https://doi.org/10.3892/br.2013.74
Copy and paste a formatted citation
x
Spandidos Publications style
Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A and Arakawa K: Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomed Rep 1: 359-364, 2013.
APA
Inui, Y., Mochida, H., Yamairi, F., Okada, M., Ishida, J., Fukamizu, A., & Arakawa, K. (2013). Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomedical Reports, 1, 359-364. https://doi.org/10.3892/br.2013.74
MLA
Inui, Y., Mochida, H., Yamairi, F., Okada, M., Ishida, J., Fukamizu, A., Arakawa, K."Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice". Biomedical Reports 1.3 (2013): 359-364.
Chicago
Inui, Y., Mochida, H., Yamairi, F., Okada, M., Ishida, J., Fukamizu, A., Arakawa, K."Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice". Biomedical Reports 1, no. 3 (2013): 359-364. https://doi.org/10.3892/br.2013.74
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