Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
May-June 2013 Volume 1 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2013 Volume 1 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis

  • Authors:
    • Yu Wang
    • Tingting Zeng
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Diagnosis of Cancer, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Adverse Drug Reaction Monitoring Center of Chengdu, High‑Tech District, Chengdu, Sichuan 610042, P.R. China
  • Pages: 479-483
    |
    Published online on: March 27, 2013
       https://doi.org/10.3892/br.2013.89
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neutrophil gelatinase‑associated lipocalin (NGAL) has been thought to play an important role in breast cancer tumorigenesis and progression. Various studies have focused on the association between NGAL and breast cancer. The aim of this meta‑analysis was to establish the overall accuracy of the NGAL test in the diagnosis of breast cancer. A comprehensive search of the literature was conducted using PubMed, OVID, ScienceDirect and the China National Knowledge Infrastructure (CNKI) databases, and our screening covered all published papers until November 2012. The relevant papers were selected according to stringent inclusion criteria. Essential data were abstracted from the included papers and further analysed by a systematic meta‑analysis. The present meta‑analysis included four study papers. The summary estimate was 64% (95% CI, 0.59‑0.69) for sensitivity and 87% (95% CI, 0.81‑0.92) for specificity. The positive likelihood (PLR), negative likelihood (NLR) and diagnostic odds (DOR) ratios were 5.63 (95% CI, 3.63‑8.74), 0.32 (95% CI, 0.14‑0.71) and 18.02 (95% CI, 9.84‑32.98), respectively. The area under the summary ROC curve (AUC) for the diagnosis of breast cancer was 0.9008. Thus, NGAL is a potential biomarker for the diagnosis of breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Gion M, Mione R, Leon AE and Dittadi R: Comparison of the diagnostic accuracy of CA27.29 and CA15.3 in primary breast cancer. Clin Chem. 45:630–637. 1999.

2 

Gion M, Mione R, Leon AE, Luftner D, Molina R, Possinger K and Robertson JF: CA27.29: a valuable marker for breast cancer management. A confirmatory multicentric study on 603 cases. Eur J Cancer. 37:355–363. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Luftner D, Luke C and Possinger K: Serum HER-2/neu in the management of breast cancer patients. Clin Biochem. 36:233–240. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Wang Y, Fang F, Shi C, et al: Evaluation of a method for the simultaneous detection of multiple tumor markers using a multiplex suspension bead array. Clin Biochem. 45:1394–1398. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Nicolini A, Carpi A, Ferrari P and Rossi G: Immunotherapy prolongs the serum CEA-TPA-CA15.3 lead time at the metastatic progression in endocrine-dependent breast cancer patients: a retrospective longitudinal study. Cancer Lett. 263:122–129. 2008. View Article : Google Scholar

6 

Flower DR: The lipocalin protein family: structure and function. Biochem J. 318(Pt 1): 1–14. 1996.

7 

Triebel S, Blaser J, Reinke H and Tschesche H: A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase. FEBS Lett. 314:386–388. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Haase M, Bellomo R, Devarajan P, Schlattmann P and Haase-Fielitz A: Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 54:1012–1024. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Kjeldsen L, Johnsen AH, Sengelov H and Borregaard N: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 268:10425–10432. 1993.PubMed/NCBI

10 

Hu L, Hittelman W, Lu T, et al: NGAL decreases E-cadherin- mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells. Lab Invest. 89:531–548. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Zhang XF, Zhang Y, Zhang XH, et al: Clinical significance of Neutrophil gelatinase-associated lipocalin (NGAL) expression in primary rectal cancer. BMC Cancer. 9:1342009. View Article : Google Scholar : PubMed/NCBI

12 

Kubben FJ, Sier CF, Hawinkels LJ, et al: Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer. Eur J Cancer. 43:1869–1876. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Zhang H, Xu L, Xiao D, et al: Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion. J Clin Pathol. 60:555–561. 2007. View Article : Google Scholar

14 

Friedl A, Stoesz SP, Buckley P and Gould MN: Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem J. 31:433–441. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Li LG, Zhou T and Hou YM: Expression and functional analysis of NGAL gene in human hepatocellular carcinoma. J Fudan Univ (Nat Sci). 51:91–98. 2012.

16 

Iannetti A, Pacifico F, Acquaviva R, et al: The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells. Proc Natl Acad Sci USA. 105:14058–14063. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Furutani M, Arii S, Mizumoto M, Kato M and Imamura M: Identification of a neutrophil gelatinase-associated lipocalin mRNA in human pancreatic cancers using a modified signal sequence trap method. Cancer Lett. 122:209–214. 1998. View Article : Google Scholar

18 

Laurell H, Bouisson M, Berthelemy P, et al: Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples. World J Gastroenterol. 12:3344–3351. 2006.

19 

Tong Z, Kunnumakkara AB, Wang H, et al: Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res. 68:6100–6108. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Mahadevan NR, Rodvold J, Almanza G, Perez AF, Wheeler MC and Zanetti M: ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner. BMC Cancer. 11:2292011.PubMed/NCBI

21 

Villalva C, Sorel N, Bonnet ML, et al: Neutrophil gelatinase-associated lipocalin expression in chronic myeloid leukemia. Leuk Lymphoma. 49:984–988. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Leng X, Lin H, Ding T, et al: Lipocalin 2 is required for BCR-ABL-induced tumorigenesis. Oncogene. 27:6110–6119. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Jones C, Mackay A, Grigoriadis A, et al: Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer. Cancer Res. 64:3037–3045. 2004. View Article : Google Scholar

24 

Yang J, Bielenberg DR, Rodig SJ, et al: Lipocalin 2 promotes breast cancer progression. Proc Natl Acad Sci USA. 106:3913–3918. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Bauer M, Eickhoff JC, Gould MN, Mundhenke C, Maass N and Friedl A: Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat. 108:389–397. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Wenners AS, Mehta K, Loibl S, et al: Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer. PLoS One. 7:e458262012. View Article : Google Scholar

27 

Stoesz SP, Friedl A, Haag JD, Lindstrom MJ, Clark GM and Gould MN: Heterogeneous expression of the lipocalin NGAL in primary breast cancers. Int J Cancer. 79:565–572. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Provatopoulou X, Gounaris A, Kalogera E, et al: Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease. BMC Cancer. 9:3902009. View Article : Google Scholar

29 

Zhang XF, Zhou SM, Wan L, et al: Relationship between NGAL expression and progression, metastasis and prognosis of breast cancer. J Pract Oncol. 23:206–210. 2008.

30 

Lv CG and Qi FJ: Expression of NGAL and MMP-9 protein in invasive breast cancer and its clinical application. Guangdong Med J. 32:1287–1289. 2011.

31 

Wang XH, Guo YY and Gou XM: Expression of NGAL in breast cancer and its clinical application. China Pract Med. 6:43–45. 2011.

32 

Qiu JM: Clinical significance of determination in tumor cells NGAL levels of breast cancer patients with immuno-histochemistry. J Radioimmunol. 25:546–548. 2012.

33 

Stuckey R, Aldridge T, Lim FL, et al: Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation. Mol Cell Endocrinol. 253:22–29. 2006. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y and Zeng T: Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis. Biomed Rep 1: 479-483, 2013.
APA
Wang, Y., & Zeng, T. (2013). Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis. Biomedical Reports, 1, 479-483. https://doi.org/10.3892/br.2013.89
MLA
Wang, Y., Zeng, T."Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis". Biomedical Reports 1.3 (2013): 479-483.
Chicago
Wang, Y., Zeng, T."Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis". Biomedical Reports 1, no. 3 (2013): 479-483. https://doi.org/10.3892/br.2013.89
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y and Zeng T: Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis. Biomed Rep 1: 479-483, 2013.
APA
Wang, Y., & Zeng, T. (2013). Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis. Biomedical Reports, 1, 479-483. https://doi.org/10.3892/br.2013.89
MLA
Wang, Y., Zeng, T."Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis". Biomedical Reports 1.3 (2013): 479-483.
Chicago
Wang, Y., Zeng, T."Neutrophil gelatinase‑associated lipocalin protein as a biomarker in the diagnosis of breast cancer: A meta‑analysis". Biomedical Reports 1, no. 3 (2013): 479-483. https://doi.org/10.3892/br.2013.89
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team