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Article

Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects

  • Authors:
    • Yan-Yan Li
    • Yun Qian
    • Chuan-Wei Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 464-468
    |
    Published online on: March 27, 2013
       https://doi.org/10.3892/br.2013.90
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Abstract

The connexin 37 (Cx37) C1019T gene polymorphism has been suggested to be correlated with increased coronary artery disease (CAD) risk, but research results remain inconsistent. To explore the relationship between the Cx37 C1019T gene polymorphism and CAD in a Chinese population, the current meta-analysis of 6 individual studies involving 1,244 CAD patients and 962 controls was conducted. The pooled odds ratios (ORs) as well as the corresponding 95% confidence intervals (CIs) were estimated using a random- or fixed-effect model. No significant association was found between Cx37 C1019T gene polymorphism and CAD in the Chinese population under the allelic (OR=0.96; 95%  CI=0.59‑1.56, P=0.87), recessive (OR=0.77, 95% CI=0.28‑2.08, P=0.60), dominant (OR=0.990, 95% CI=0.773‑1.266, P=0.934), additive (OR=1.000, 95% CI=0.736‑1.359, P=1.000), homozygous (OR=1.062, 95% CI=0.598‑1.887, P=0.836) or heterozygous (OR=1.017, 95% CI=0.802-1.291, P=0.888) genetic models. Cx37 C1019T gene polymorphism was not suggested to be associated with CAD susceptibility in the Chinese population. In conclusion, no association was found between Cx37 C1019T gene polymorphism and CAD in the Chinese population.
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1 

Li JJ: Inflammation: an important mechanism for different clinical entities of coronary artery diseases. Chin Med J (Engl). 118:1817–1826. 2005.PubMed/NCBI

2 

Hu D: Cardiology in new millennium: what will the 21st century bring. Chin Med J (Engl). 113:3–4. 2000.PubMed/NCBI

3 

Yeh HI, Lai YJ, Chang HM, Ko YS, Severs NJ and Tsai CH: Multiple connexin expression in regenerating arterial endothelial gap junctions. Arterioscler Thromb Vasc Biol. 20:1753–1762. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Derouette JP, Wong C, Burnier L, et al: Molecular role of Cx37 in advanced atherosclerosis: a micro-array study. Atherosclerosis. 206:69–76. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Van Camp G, Coucke P, Speleman F, Van Roy N, Beyer EC, Oostra BA and Willems PJ: The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195. Genomics. 30:402–403. 1995.PubMed/NCBI

6 

Cooper CD, Solan JL, Dolejsi MK and Lampe PD: Analysis of connexin phosphorylation sites. Methods. 20:196–204. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Listì F, Candore G, Lio D, et al: Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily. Int J Cardiol. 102:269–271. 2005.PubMed/NCBI

8 

Wong CW, Christen T, Pfenniger A, James RW and Kwak BR: Do allelic variants of the connexin37 1019 gene polymorphism differentially predict for coronary artery disease and myocardial infarction? Atherosclerosis. 191:355–361. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Zhang SR, Xu LX, Zhang HQ, Gao QQ, Lin J and Huang WJ: The association between Connexin 37 gene C1019T polymorphism and coronary heart disease. Prev and Treat of Cardio-Cereb-Vasc Dis. 7:390–392. 2007.

10 

Han Y, Xi S, Zhang X, Yan C, Yang Y and Kang J: Association of Connexin 37 gene polymorphisms with risk of coronary artery disease in northern Han Chinese. Cardiology. 110:260–265. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Zhang CL, Wang Q, Zheng L, et al: Association study between C1019T polymorphism in the connexin37 gene and acute myocardial infarction in patients from Cantonese population of China. J Guangxi Med Univ. 25:844–847. 2008.

12 

Cochran WG: The effectiveness of adjustment by subclassification in removing bias in observational studies. Biometrics. 24:295–313. 1968. View Article : Google Scholar : PubMed/NCBI

13 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

14 

Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI

15 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Yeh HI, Chou Y, Liu HF, Chang SC and Tsai CH: Connexin37 gene polymorphism and coronary artery disease in Taiwan. Int J Cardiol. 81:251–255. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Xie XJ, Guo WY, Li LS, Shu Q, Jiang WR, Zhang SZ and Li F: Association between Connexin 37 gene polymorphism and coronary heart disease. Chin Heart J. 18:539–541. 2006.

18 

Feng W, Wang HJ and Wang Y: Relevance of Connexin 37 gene C1019T polymorphism and coronary heart disease in Han population in Anhui region. Chin J Cardiovasc Rehabil Med. 19:33–36. 2010.

19 

Shimokawa H: Primary endothelial dysfunction: atherosclerosis. J Mol Cell Cardiol. 31:23–37. 1999. View Article : Google Scholar

20 

Severs NJ, Rothery S, Dupont E, et al: Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system. Microsc Res Tech. 52:301–322. 2001. View Article : Google Scholar

21 

Wong CW, Christen T, Roth I, et al: Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat Med. 12:950–954. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Galkina E and Ley K: Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol. 27:2292–2301. 2007. View Article : Google Scholar

23 

Yeh HI, Rothery S, Dupont E, Coppen SR and Severs NJ: Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ Res. 83:1248–1263. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Collings A, Islam MS, Juonala M, et al: Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns study. Atherosclerosis. 195:379–384. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Lanfear DE, Jones PG, Marsh S, Cresci S, Spertus JA and McLeod HL: Connexin37 (GJA4) genotype predicts survival after an acute coronary syndrome. Am Heart J. 154:561–566. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Wang F, Yang C, Song Y, Jiang Y and Ding Z: Periostin gene polymorphisms, protein levels and risk of incident coronary artery disease. Mol Biol Rep. 39:359–367. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Saedi M, Vaisi-Raygani A, Khaghani S, et al: Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease. Mol Biol Rep. 39:555–562. 2012.

28 

Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM and Hussain T: Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes. Mol Biol Rep. 38:3703–3708. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Qian Y and Zhou C: Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects. Biomed Rep 1: 464-468, 2013.
APA
Li, Y., Qian, Y., & Zhou, C. (2013). Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects. Biomedical Reports, 1, 464-468. https://doi.org/10.3892/br.2013.90
MLA
Li, Y., Qian, Y., Zhou, C."Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects". Biomedical Reports 1.3 (2013): 464-468.
Chicago
Li, Y., Qian, Y., Zhou, C."Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects". Biomedical Reports 1, no. 3 (2013): 464-468. https://doi.org/10.3892/br.2013.90
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Qian Y and Zhou C: Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects. Biomed Rep 1: 464-468, 2013.
APA
Li, Y., Qian, Y., & Zhou, C. (2013). Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects. Biomedical Reports, 1, 464-468. https://doi.org/10.3892/br.2013.90
MLA
Li, Y., Qian, Y., Zhou, C."Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects". Biomedical Reports 1.3 (2013): 464-468.
Chicago
Li, Y., Qian, Y., Zhou, C."Lack of association between the connexin 37 C1019T gene polymorphism and coronary artery disease in a Chinese population: Meta-analysis of 2,206 subjects". Biomedical Reports 1, no. 3 (2013): 464-468. https://doi.org/10.3892/br.2013.90
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