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Article

Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review)

Corrigendum in: /10.3892/br.2019.1249
  • Authors:
    • Kiyoko Umene
    • Kouji Banno
    • Iori Kisu
    • Megumi Yanokura
    • Yuya Nogami
    • Kosuke Tsuji
    • Kenta Masuda
    • Arisa Ueki
    • Yusuke Kobayashi
    • Wataru Yamagami
    • Hiroyuki Nomura
    • Eiichiro Tominaga
    • Nobuyuki Susumu
    • Daisuke Aoki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160‑8582, Japan
  • Pages: 335-340
    |
    Published online on: March 27, 2013
       https://doi.org/10.3892/br.2013.91
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Abstract

Chemotherapy and surgery are important treatment strategies for gynecologic malignant tumors such as ovarian, cervical and endometrial cancer. However, many anticancer drugs currently available are cytotoxic and cause strong adverse reactions in patients. Aurora kinases have attracted increasing attention in recent years as serine/threonine kinases with various roles in cell division, including chromosomal agglutination and segregation, functions of centromeres, centrosomal maturation, spindle formation and cytokinesis. Aurora kinases are overexpressed in a number of cancers and recent studies have shown that they are involved in onco­genesis and cause an aberrant increase in centrosome number, emergence of polykaryocytes and failure of cancer inhibition mechanisms. Thus, drugs that inhibit Aurora kinases are likely to exert anticancer effects in various fields, including the gynecologic field. Aurora kinase inhibitors exert antitumor effects in monotherapy and synergistic effects in combination therapy with taxane‑based anticancer agents for gynecologic tumors and are likely to increase the efficacy of existing anticancer drugs. Current Aurora kinase inhibitors include ZM447439, Hesperadin, VX‑680/MK‑0457, AT9283 and Barasertib, and clinical trials are ongoing to verify the effects of these inhibitors.
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Copy and paste a formatted citation
Spandidos Publications style
Umene K, Banno K, Kisu I, Yanokura M, Nogami Y, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Yamagami W, et al: Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249. Biomed Rep 1: 335-340, 2013.
APA
Umene, K., Banno, K., Kisu, I., Yanokura, M., Nogami, Y., Tsuji, K. ... Aoki, D. (2013). Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249. Biomedical Reports, 1, 335-340. https://doi.org/10.3892/br.2013.91
MLA
Umene, K., Banno, K., Kisu, I., Yanokura, M., Nogami, Y., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249". Biomedical Reports 1.3 (2013): 335-340.
Chicago
Umene, K., Banno, K., Kisu, I., Yanokura, M., Nogami, Y., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249". Biomedical Reports 1, no. 3 (2013): 335-340. https://doi.org/10.3892/br.2013.91
Copy and paste a formatted citation
x
Spandidos Publications style
Umene K, Banno K, Kisu I, Yanokura M, Nogami Y, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Yamagami W, et al: Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249. Biomed Rep 1: 335-340, 2013.
APA
Umene, K., Banno, K., Kisu, I., Yanokura, M., Nogami, Y., Tsuji, K. ... Aoki, D. (2013). Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249. Biomedical Reports, 1, 335-340. https://doi.org/10.3892/br.2013.91
MLA
Umene, K., Banno, K., Kisu, I., Yanokura, M., Nogami, Y., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249". Biomedical Reports 1.3 (2013): 335-340.
Chicago
Umene, K., Banno, K., Kisu, I., Yanokura, M., Nogami, Y., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Tominaga, E., Susumu, N., Aoki, D."Aurora kinase inhibitors: Potential molecular‑targeted drugs for gynecologic malignant tumors (Review) Corrigendum in /10.3892/br.2019.1249". Biomedical Reports 1, no. 3 (2013): 335-340. https://doi.org/10.3892/br.2013.91
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