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Article

Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

  • Authors:
    • Xifu Shang
    • Zhengliang Luo
    • Xu Li
    • Fei Hu
    • Qichun Zhao
    • Wenzhi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
  • Pages: 594-598
    |
    Published online on: April 9, 2013
       https://doi.org/10.3892/br.2013.93
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Abstract

Testing for genetic risk associations between Factor V Leiden (FVL) and the osteonecrosis of femoral head (ONFH) is common, however, inconsistent results have been previously obtained. To summarize results on the association of FVL mutation polymorphism with ONFH in various populations and to calculate the overall genetic risk factors, we performed a search of electronic databases including PubMed, Elsevier Science Direct, Chinese National Knowledge Infrastructure and the Chinese Biomedical Database to identify published studies correlating the FVL mutation with ONFH. Statistical analysis was performed using Review Manager (RevMan) version 5.0 and Stata statistical software (version 10). We identified 57 titles and included 7 studies comprising 481 cases and 867 controls in this meta‑analysis. The groups were pooled, and a significant association between FVL mutation and increased ONFH was found (OR=4.55, 95% CI, 2.75‑7.52, P<0.00001). This meta‑analysis demonstrated that FVL plays an important role in non‑Asian populations. Large sample studies including different ethnic groups and age‑ and gender‑matched groups, as well as multiple gene polymorphism detection should be considered to clarify the association of FVL mutation polymorphism and ONFH susceptibility in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Shang X, Luo Z, Li X, Hu F, Zhao Q and Zhang W: Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility. Biomed Rep 1: 594-598, 2013.
APA
Shang, X., Luo, Z., Li, X., Hu, F., Zhao, Q., & Zhang, W. (2013). Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility. Biomedical Reports, 1, 594-598. https://doi.org/10.3892/br.2013.93
MLA
Shang, X., Luo, Z., Li, X., Hu, F., Zhao, Q., Zhang, W."Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility". Biomedical Reports 1.4 (2013): 594-598.
Chicago
Shang, X., Luo, Z., Li, X., Hu, F., Zhao, Q., Zhang, W."Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility". Biomedical Reports 1, no. 4 (2013): 594-598. https://doi.org/10.3892/br.2013.93
Copy and paste a formatted citation
x
Spandidos Publications style
Shang X, Luo Z, Li X, Hu F, Zhao Q and Zhang W: Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility. Biomed Rep 1: 594-598, 2013.
APA
Shang, X., Luo, Z., Li, X., Hu, F., Zhao, Q., & Zhang, W. (2013). Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility. Biomedical Reports, 1, 594-598. https://doi.org/10.3892/br.2013.93
MLA
Shang, X., Luo, Z., Li, X., Hu, F., Zhao, Q., Zhang, W."Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility". Biomedical Reports 1.4 (2013): 594-598.
Chicago
Shang, X., Luo, Z., Li, X., Hu, F., Zhao, Q., Zhang, W."Meta‑analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility". Biomedical Reports 1, no. 4 (2013): 594-598. https://doi.org/10.3892/br.2013.93
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