|
1
|
Perou CM, Sorlie T, Eisen MB, van de Rijn
M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA,
et al: Molecular portraits of human breast tumors. Nature.
406:747–752. 2000. View
Article : Google Scholar : PubMed/NCBI
|
|
2
|
Slamon DJ, Clark GM, Wong SG, Levin WJ,
Ullrich A and McGuire WL: Human breast cancer: correlation of
relapse and survival with amplification of the HER-2/neu oncogene.
Science. 235:177–182. 1987. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Slamon DJ, Godolphin W, Jones LA, Holt JA,
Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, et al:
Studies of the HER-2/neu proto-oncogene in human breast and ovarian
cancer. Science. 244:707–712. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Yarden Y and Sliwkowski MX: Untangling the
ErbB signalling network. Nat Rev Mol Cell Biol. 2:127–137. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Klapper LN, Kirschbaum MH, Sela M and
Yarden Y: Biochemical and clinical implications of the ErbB/HER
signaling network of growth factor receptors. Adv Cancer Res.
77:25–79. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Hynes NE and Lane HA: ERBB receptors and
cancer: the complexity of targeted inhibitors. Nat Rev Cancer.
5:341–354. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
7
|
Graus-Porta D, Beerli RR, Daly JM and
Hynes NE: ErbB-2, the preferred heterodimerization partner of all
ErbB receptors, is a mediator of lateral signaling. EMBO J.
16:1647–1655. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Molina MA, Codony-Servat J, Albanell J,
Rojo F, Arribas J and Baselga J: Trastuzumab (herceptin), a
humanized anti-Her2 receptor monoclonal antibody, inhibits basal
and activated Her2 ectodomain cleavage in breast cancer cells.
Cancer Res. 61:4744–4749. 2001.
|
|
9
|
Baselga J, Albanell J, Molina MA and
Arribas J: Mechanism of action of trastuzumab and scientific
update. Semin Oncol. 28(5 Suppl 16): 4–11. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Spector NL and Blackwell KL: Understanding
the mechanisms behind trastuzumab therapy for human epidermal
growth factor receptor 2-positive breast cancer. J Clin Oncol.
27:5838–5847. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Slamon DJ, Leyland-Jones B, Shak S, Fuchs
H, Paton V, Baiamonde A, Fleming T, Eiermann W, Wolter J, Pegram M,
et al: Use of chemotherapy plus a monoclonal antibody against HER2
for metastatic breast cancer that overexpresses HER2. N Engl J Med.
344:783–792. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Marty M, Cognetti F, Maraninchi D, Snyder
R, Mauriac L, Tubiana-Hulin M, Chan S, Grimes D, Antón A, Lluch A,
et al: Randomized phase II trial of the efficacy and safety of
trastuzumab combined with docetaxel in patients with human
epidermal growth factor receptor 2-positive metastatic breast
cancer administered as first-line treatment: the M77001 study
group. J Clin Oncol. 23:4265–4274. 2005. View Article : Google Scholar
|
|
13
|
Gasparini G, Gion M, Mariani L, Papaldo P,
Crivellari D, Filippelli G, Morabito A, Silingardi V, Torino F,
Spada A, et al: Randomized phase II trial of weekly paclitaxel
alone versus trastuzumab plus weekly paclitaxel as first-line
therapy of patients with Her-2 positive advanced breast cancer.
Breast Cancer Res Treat. 101:355–365. 2007. View Article : Google Scholar
|
|
14
|
Burstein HJ, Keshaviah A, Baron AD, Hart
RD, Lambert-Falls R, Marcom PK, Gelman R and Winer EP: Trastuzumab
plus vinorelbine or taxane chemotherapy for HER2-overexpressing
metastatic breast cancer: the trastuzumab and vinorelbine or taxane
study. Cancer. 110:965–972. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Yamamoto D, Iwase S, Kitamura K, Odagiri
H, Yamamoto C and Naqumo Y: A phase II study of trastuzumab and
capecitabine for patients with HER2-overexpressing metastatic
breast cancer: Japan Breast Cancer Research Network (JBCRN) 00
Trial. Cancer Chemother Pharmacol. 61:509–514. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Pegram MD, Lipton A, Hayes DF, Weber BL,
Baselga JM, Tripathy D, Baly D, Bauqhman SA, Twaddell T, Glaspy JA
and Slamon DJ: Phase II study of receptor-enhanced chemosensitivity
using recombinant humanized anti-p185HER2/neu monoclonal antibody
plus cisplatin in patients with HER2/neu-overexpressing metastatic
breast cancer refractory to chemotherapy treatment. J Clin Oncol.
16:2659–2671. 1998.
|
|
17
|
Pegram MD, Pienkowski T, Northfelt DW,
Eiermann W, Patel R, Fumoleau P, Quan E, Crown J, Toppmeyer D,
Smylie M, et al: Results of two open-label, multicenter phase II
studies of docetaxel, platinum salts, and trastuzumab in
HER2-positive advanced breast cancer. J Natl Cancer Inst.
96:759–769. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yardley DA, Burris HA 3rd, Simons L,
Spigel DR, Greco FA, Barton JH, Shipley D, Drosick D and Hainsworth
JD: A phase II trial of gemcitabine/carboplatin with or without
trastuzumab in the first-line treatment of patients with metastatic
breast cancer. Clin Breast Cancer. 8:425–431. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Vogel CL, Cobleigh MA, Tripathy D, Gutheil
JC, Harris LN, Fehrenbacher L, Slamon DJ, Murphy M, Novotny WF,
Burchmore M, et al: Efficacy and safety of trastuzumab as a single
agent in first-line treatment of HER2-overexpressing metastatic
breast cancer. J Clin Oncol. 20:719–726. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Kaufman B, Mackey JR, Clemens MR, Bapsy
PP, Vaid A, Wardley A, Tjulandin S, Jahn M, Lehle M, Feyereislova
A, et al: Trastuzumab plus anastrozole versus anastrozole alone for
the treatment of postmenopausal women with human epidermal growth
factor receptor 2-positive, hormone receptor-positive metastatic
breast cancer: results from the randomized phase III TAnDEM study.
J Clin Oncol. 27:5529–5537. 2009. View Article : Google Scholar
|
|
21
|
Gelmon KA, Mackey J, Verma S, Gertler SZ,
Bangemann N, Klimo P, Schneeweiss A, Bremer K, Soulieres D, Tonkin
K, et al: Use of trastuzumab beyond disease progression:
observations from a retrospective review of case histories. Clin
Breast Cancer. 5:52–62. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Tripathy D, Slamon DJ, Cobleigh M, Arnold
A, Saleh M, Mortimer JE, Murphy M and Stewart SJ: Safety of
treatment of metastatic breast cancer with trastuzumab beyond
disease progression. J Clin Oncol. 22:1063–1070. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Von Minckwitz G, du Bois A, Schmidt M,
Maass N, Cufer T, de Jongh FE, Maartense E, Zielinski C, Kaufmann
M, Bauer W, et al: Trastuzumab beyond progression in human
epidermal growth factor receptor 2-positive advanced breast cancer:
a german breast group 26/breast international group 03–05 study. J
Clin Oncol. 27:1999–2006. 2009.PubMed/NCBI
|
|
24
|
Yin W, Jiang Y, Shen Z, Shao Z and Lu J:
Trastuzumab in the adjuvant treatment of HER2-positive early breast
cancer patients: a meta-analysis of published randomized controlled
trials. PLoS One. 6:e210302011. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Joerger M, Thurlimann B and Huober J:
Small HER2-positive, node-negative breast cancer: who should
receive systemic adjuvant treatment? Ann Oncol. 22:17–23. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Goldhirsch A, Piccart-Gebhart MJ, Procter
M, de Azambuja E, Weber HA, Untch M, Smith I, Gianni L, Jackisch C,
Cameron D, Bell R, Dowsett M, et al: HERA TRIAL: 2 years versus 1
year of trastuzumab after adjuvant chemotherapy in women with
HER2-positive early breast cancer at 8 years of median follow up.
In: Presented at: 35th Annual San Antonio Breast Cancer Symposium;
December 4–8, 2012; San Antonio, TX. abs. S5-2.
|
|
27
|
Perez EA, Dueck AC, Press MF, Jenkins RB,
Kim C, Chen B, Villalobos I, Paik S, Buyse M, Wiktor AE, et al:
Results of chemotherapy alone, with sequential or concurrent
addition of 52 weeks of trastuzumab in the NCCTG N9831
HER2-positive adjuvant breast cancer trial. Cancer Res.
70:a56402009.
|
|
28
|
Mackey J, Mcleod D, Ragaz J, Gelmon K,
Verma S, Pritchard K, Laing K, Provencher L and Charbonneau LF:
Adjuvant targeted therapy in early breast cancer. Cancer.
115:1154–1168. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Buzdar AU, Ibrahim NK, Francis D, Booser
DJ, Thomas ES, Theriault RL, Pusztai L, Green MC, Arun BK, Giordano
SH, et al: Significantly higher pathologic complete remission rate
after neoadjuvant therapy with trastuzumab, paclitaxel, and
epirubicin chemotherapy : results of a randomized trial in human
epidermal growth factor receptor 2-positive operable breast cancer.
J Clin Oncol. 23:3676–3685. 2005. View Article : Google Scholar
|
|
30
|
Valachis A, Mauri D, Polyzos NP,
Chlouverakis G, Mavroudis D and Georgoulias V: Trastuzumab combined
to neoadjuvant chemotherapy in patients with HER2-positive breast
cancer: a systematic review and meta-analysis. Breast. 20:485–490.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
NCCN Clinical Practice Guidelines in
Oncology: Breast Cancer. Version 1.2013. Available at https://www.nccn.org/patients: Accessed
February 22, 2013.
|
|
32
|
Garnock-Jones KP, Keating GM and Scott LJ:
Trastuzumab: a review of its use as adjuvant treatment in human
epidermal growth factor receptor 2 (HER2)-positive early breast
cancer. Drugs. 70:215–239. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Seidman A, Hudis C, Pierri MK, Shak S,
Paton V, Ashby M, Murphy M, Stewart SJ and Keefe D: Cardiac
dysfunction in the trastuzumab clinical trials experience. J Clin
Oncol. 20:1215–1221. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Rastogi P, Jeong J, Geyer CE, Romond EH,
Swain SM, Ewer MS, Rathi V, Fehrenbacher L, Brufsky A, Azar CA, et
al: Five-year update of cardiac dysfunction on NSABP B-31, a
randomized trial of sequential doxorubicin/cyclophosphamide
(AC)→paclitaxel (T) compared to AC→T with trastuzumab (H). J Clin
Oncol. 25:6s. abs. LBA 513. 2007.
|
|
35
|
Perez EA, Suman VJ, Davidson NE, Sledge
GW, Kaufman PA, Hudis CA, Martino S, Gralow JR, Dakhil SR, Ingle
JN, et al: Cardiac safety analysis of doxorubicin and
cyclophosphamide followed by paclitaxel with or without trastuzumab
in the North Central Cancer Treatment Group N9831 adjuvant breast
cancer trial. J Clin Oncol. 26:1231–1238. 2008. View Article : Google Scholar
|
|
36
|
Buzdar AU, Valero V, Ibrahim NK, Francis
D, Broglio KR, Theriault RL, Pusztai L, Green MC, Singletary SE,
Hunt KK, et al: Neoadjuvant therapy with paclitaxel followed by
5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and
concurrent trastuzumab in human epidermal growth factor receptor
2-positive operable breast cancer: an update of the initial
randomized study population and data of additional patients treated
with the same regimen. Clin Cancer Res. 13:228–233. 2007.
|
|
37
|
Kelly H, Kimmick G, Dees EC, Collichio F,
Gatti L, Sawyer L, Ivanova A, Dressler L, Graham ML and Carey LA:
Response and cardiac toxicity of trastuzumab given in conjunction
with weekly paclitaxel after doxorubicin/cyclophosphamide. Clin
Breast Cancer. 7:237–243. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Nahta R and O’Regan RM: Evolving
strategies for overcoming resistance to HER2-directed therapy:
targeting the PI3K/Akt/mTOR pathway. Clin Breast Cancer.
10:S72–S78. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Aqus DB, Akita RW, Fox WD, Lewis GD,
Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K,
et al: Targeting ligand-activated ErbB2 signaling inhibits breast
and prostate tumor growth. Cancer Cell. 2:127–137. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Franklin MC, Carey KD, Vajdos FF, Leahy
DJ, de Vos AM and Sliwkowski MX: Insights into ErbB signaling from
the structure of the ErbB2-pertuzumab complex. Cancer Cell.
5:317–328. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Aqus DB, Gordon MS, Taylor C, Natale RB,
Karlan B, Mendelson DS, Press MF, Allison DE, Sliwkowski MX,
Lieberman G, et al: Phase I clinical study of pertuzumab, a novel
HER dimerization inhibitor, in patients with advanced cancer. J
Clin Oncol. 23:2534–2543. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Scheuer W, Friess T, Burtscher H,
Bossenmaier B, Endl J and Hasmann M: Strongly enhanced antitumor
activity of trastuzumab and pertuzumab combination treatment on
HER2-positive human xenograft tumor models. Cancer Res.
69:9330–9336. 2009. View Article : Google Scholar
|
|
43
|
Baselga J, Gelmon KA, Verma S, Wardley A,
Conte P, Miles D, Bianchi G, Cortes J, McNally VA, Ross GA, et al:
Phase II trial of pertuzumab and trastuzumab in patients with human
epidermal growth factor receptor 2-positive metastatic breast
cancer that progressed during prior trastuzumab therapy. J Clin
Oncol. 28:1138–1144. 2010. View Article : Google Scholar
|
|
44
|
Baselga J, Cortés J, Kim SB, Im SA, Hegg
R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A, et al:
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast
cancer. N Engl J Med. 366:109–119. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
No authors listed:. FDA approves
pertuzumab for breast cancer. Cancer Discov. 2:OF62012.
|
|
46
|
Gianni L, Pienkowski T, Im YH, Roman L,
Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J,
Im SA, et al: Efficacy and safety of neoadjuvant pertuzumab and
trastuzumab in women with locally advanced, inflammatory, or early
HER2-positive breast cancer (NeoSphere): a randomised multicentre,
open-label, phase 2 trial. Lancet Oncol. 13:25–32. 2012. View Article : Google Scholar
|
|
47
|
Von Minckwitz G, Loibl S and Untch M: What
is the current standard of care for anti-HER2 neoadjuvant therapy
in breast cancer? Oncology (Williston Park). 26:20–26.
2012.PubMed/NCBI
|
|
48
|
Lewis Phillips GD, Li G, Dugger DL,
Crocker LM, Parsons KL, Mai E, Blattler WA, Lambert JM, et al:
Targeting HER2-positive breast cancer with trastuzumab-DM1, an
antibody-cytotoxic drug conjugate. Cancer Res. 68:9280–9290.
2008.PubMed/NCBI
|
|
49
|
Krop IE, Beeram M, Modi S, Jones SF,
Holden SN, Yu W, Girish S, Tibbitts J, Yi JH, Sliwkowski MX, et al:
Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate,
given every 3 weeks to patients with HER2-positive metastatic
breast cancer. J Clin Oncol. 28:2698–2704. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Krop IE, Lorusso P, Miller KD, Modi S,
Yardley D, Rodriguez G, Guardino E, Lu M, Zheng M, Girish S, et al:
A phase II study of trastuzumab emtansine in patients with human
epidermal growth factor receptor 2-positive metastatic breast
cancer who were previously treated with trastuzumab, lapatinib, an
anthracycline, a taxane, and capecitabine. J Clin Oncol.
30:3234–3241. 2012. View Article : Google Scholar
|
|
51
|
Perez EA, Dirix L, Kocsis J, Bianchi GV,
Lu J, Vinholes J, Guardino E, Song C, Tong B, Ng V, et al: Efficacy
and safety of trastuzumab-DM1 vs trastuzumab plus docetaxel in
HER2-positive metastatic breast cancer patients with no prior
chemotherapy for metastatic disease: preliminary results of a
randomized, multicenter, open-label phase 2 study (TDM4450G). Ann
Oncol. 21:abs. LBA 3. 2010.
|
|
52
|
Hurvitz S, Dirix L, Kocsis J, Bianchi GV,
Lu J, Vinholes J, Guardino E, Song C, Tong B, et al: Trastuzumab
emtansine (T-DM1) vs trastuzumab plus docetaxel (H+T) in
previously-untreated HER2-positive metastatic breast cancer (MBC):
primary results of a randomized, multicenter, open-label phase II
study (TDM4450g/B021976). Eur J Cancer. 47:Abs. 50012011.
|
|
53
|
Dieras V, Harbeck N and Albain K: A phase
Ib/II trial of trastuzumab-DM1 with pertuzumab for patients with
HER2-positive, locally advanced or metastatic breast cancer:
interim efficacy and safety results. In: Presented at: 33rd Annual
San Antonio Breast Cancer Symposium; December 8–12, 2010; San
Antonio, TX. abs. P3-14-01.
|
|
54
|
Medina PJ and Goodin S: Lapatinib: a dual
inhibitor of human epidermal growth factor receptor tyrosine
kinases. Clin Ther. 30:1426–1447. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Tevaarwerk AJ and Kolesar JM: Lapatinib: a
small-molecule inhibitor of epidermal growth factor receptor and
human epidermal growth factor receptor-2 tyrosine kinases used in
the treatment of breast cancer. Clin Ther. 31:2332–2348. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Geyer CE, Forster J, Lindquist D, Chan S,
Romieu CG, Pienkowski T, Jagiello-Gruszfeld A, Crown J, Chan A,
Kaufman B, et al: Lapatinib plus capecitabine for HER2-positive
advanced breast cancer. N Engl J Med. 355:2733–2743. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Di Leo A, Gomez HL, Aziz Z, Zvirbule Z,
Bines J, Arbushites MC, Guerrera SF, Koehler M, Oliva C, Stein SH,
et al: Phase III, double-blind, randomized study comparing
lapatinib plus paclitaxel with placebo plus paclitaxel as
first-line treatment for metastatic breast cancer. J Clin Oncol.
26:5544–5552. 2008.
|
|
58
|
Yardley DA, Hart L, Bosserman L, Salleh
MN, Waterhouse DM, Hagan MK, Richards P, DeSilvio ML, Mahoney JM
and Nagarwala Y: Phase II study evaluating lapatinib in combination
with nab-paclitaxel in HER2-overexpressing metastatic breast cancer
patients who have received no more than one prior chemotherapeutic
regimen. Breast Cancer Res Treat. 137:457–464. 2013. View Article : Google Scholar
|
|
59
|
Valero M, Ruiz-Borrego M and Salvador D:
Cisplatin, gencitabine, and lapatinib in patients with
HER2-positive meta-static breast cancer: an experience in routine
clinical practice. ASCO Annual Meeting J Clin Oncol. 29:abs.
e110052011.
|
|
60
|
Johnston S, Pippen J Jr, Pivot X,
Lichinitser M, Sadeghi S, Dieras V, Gomez HL, Romieu G, Manikhas A,
Kennedy MJ, et al: Lapatinib combined with letrozole versus
letrozole and placebo as first-line therapy for postmenopausal
hormone receptor-positive metastatic breast cancer. J Clin Oncol.
27:5538–5546. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Blackwell KL, Burstein HJ, Storniolo AM,
Rugo HS, Sledge G, Aktan G, Ellis C, Florance A, Vukelja S,
Bischoff J, et al: Overall survival benefit with lapatinib in
combination with trastuzumab for patients with human epidermal
growth factor receptor 2-positive metastatic breast cancer: final
results from the EGF104900 Study. J Clin Oncol. 30:2585–2592. 2012.
View Article : Google Scholar
|
|
62
|
Gomez HL, Doval DC, Chavez MA, Ang PC,
Aziz Z, Nag S, Ng C, Franco SX, Chow LW, Arbushites MC, et al:
Efficacy and safety of lapatinib as first-line therapy for
ErbB2-amplified locally advanced or metastatic breast cancer. J
Clin Oncol. 26:2999–3005. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Blackwell KL, Pegram MD, Tan-Chiu E,
Schwartzberg LS, Arbushites MC, Maltzman JD, Forster JK, Rubin SD,
Stein SH and Burstein HJ: Single-agent lapatinib for
HER2-overexpressing advanced or metastatic breast cancer that
progressed on first- or secondline trastuzumab-containing regimens.
Ann Oncol. 20:1026–1031. 2009. View Article : Google Scholar
|
|
64
|
Lai R, Dang CT, Malkin MG and Abrey LE:
The risk of central nervous system metastases after trastuzumab
therapy in patients with breast carcinoma. Cancer. 101:810–816.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Cameron D, Casey M, Press M, Lindquist D,
Pienkowski T, Romieu CG, Chan S, Jagiello-Gruszfeld A, Kaufman B,
Crown J, et al: A phase III randomized comparison of lapatinib plus
capecitabine versus capecitabine alone in women with advanced
breast cancer that has progressed on trastuzumab: updated efficacy
and biomarker analyses. Breast Cancer Res Treat. 112:533–543. 2008.
View Article : Google Scholar
|
|
66
|
Lin NU, Carey LA, Liu MC, Younger J, Come
SE, Ewend M, Harris GJ, Bullitt E, Van den Abbeele AD, Henson JW,
et al: Phase II trial of lapatinib for brain metastases in patients
with human epidermal growth factor receptor 2-positive breast
cancer. J Clin Oncol. 26:1993–1999. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Ro J, Park S, Kim S, Kim TY, Im YH, Rha
SY, Chung JS, Moon H and Santillana S: Clinical outcomes of
HER2-positive metastatic breast cancer patients with brain
metastasis treated with lapatinib and capecitabine: an open-label
expanded access study in Korea. BMC Cancer. 12:3222012. View Article : Google Scholar
|
|
68
|
Yap YS, Cornelio GH, Devi BC, Khorprasert
C, Kim SB, Kim TY, Lee SC, Park YH, Sohn JH, Sutandyo N, et al:
Brain metastases in Asian HER2-positive breast cancer patients:
anti-HER2 treatments and their impact on survival. Br J Cancer.
107:1075–1082. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Valachis A, Nearchou A, Lind P and Mauri
D: Lapatinib, trastuzumab or the combination added to preoperative
chemotherapy for breast cancer: a meta-analysis of randomized
evidence. Breast Cancer Res Treat. 135:655–662. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Kopper L: Lapatinib: a sword with two
edges. Pathol Oncol Res. 14:1–8. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Tsou HR, Overbeek-Klumpers EG, Hallett WA,
Reich MF, Floyd MB, Johnson BD, Michalak RS, Nilakantan R,
Discafani C, Golas J, et al: Optimization of
6,7-disubstituted-4-(arylamino) quinoline-3-carbonitriles as orally
active, irreversible inhibitors of human epidermal growth factor
receptor-2 kinase activity. J Med Chem. 48:1107–1131. 2005.
View Article : Google Scholar
|
|
72
|
Burstein HJ, Sun Y, Dirix LY, Jiang Z,
Paridaens R, Tan AR, Awada A, Ranade A, Jiao S, Schwartz G, et al:
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor,
in patients with advanced ErbB2-positive breast cancer. J Clin
Oncol. 28:1301–1307. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Awada A, Dirix L, Manso Sanchez L, Xu B,
Luu T, Dieras V, Hershman DL, Agrapart V, Ananthakrishnan R and
Staroslawska E: Safety and efficacy of neratinib (HKI-272) plus
vinorelbine in the treatment of patients with ErbB2-positive
metastatic breast cancer pretreated with anti-HER2 therapy. Ann
Oncol. 24:109–116. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Li D, Ambrogio L, Shimamura T, Kubo S,
Takahashi M, Chirieac LR, Padera RF, Shapiro GI, Baum A,
Himmelsbach F, et al: BIBW2992, an irreversible EGFR/HER2 inhibitor
highly effective in preclinical lung cancer models. Oncogene.
27:4702–4711. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Lin NU, Winer EP, Wheatley D, Carey LA,
Houston S, Mendelson D, Munster P, Frakes L, Kelly S, Garcia AA, et
al: A phase II study of afatinib (BIBW 2992), an irreversible ErbB
family blocker, in patients with HER2-positive metastatic breast
cancer progressing after trastuzumab. Breast Cancer Res Treat.
133:1057–1065. 2012. View Article : Google Scholar : PubMed/NCBI
|