CASP‑1, ‑2 and ‑5 gene polymorphisms and cancer risk: A review and meta‑analysis

Pan,Ying‑Li; Liu,Wei; Gao,Cai‑Xiang; Shang,Zuo; Ning,Li‑Juan; Liu,Xing

doi:10.3892/br.2013.98

July-August 2013 Volume 1 Issue 4

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July-August 2013 Volume 1 Issue 4

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Article

CASP‑1, ‑2 and ‑5 gene polymorphisms and cancer risk: A review and meta‑analysis

Authors:
- Ying‑Li Pan
- Wei Liu
- Cai‑Xiang Gao
- Zuo Shang
- Li‑Juan Ning
- Xing Liu
View Affiliations / Copyright

Affiliations: Department of Nursing, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China
Pages: 511-516
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Published online on: April 25, 2013

https://doi.org/10.3892/br.2013.98
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Abstract

Accumulating evidence suggests the CASP gene family is important in the development of carcinogenesis. These genetic polymorphisms have been extensively investigated as a potential risk factor for cancer, but results have been inconclusive. This Human Genome Epidemiology (HuGE) review and meta‑analysis was performed to investigate the associations between CASP‑1, ‑2 and ‑5 and cancer risk. A literature search of Pubmed, Embase, Web of Science and CBM databases was conducted from inception through September 1st, 2012. Four case‑control studies with a total of 1,592 cancer cases and 1,833 healthy controls were included in the present meta‑analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Five polymorphisms were examined, including rs501192 (G>A), rs4647297 (C>G), rs507879 (T>C), rs3181320 (G>C) and rs523104 (G>C). Meta‑analysis results showed that the rs3181320*C allele/carrier were associated with increased risk of various types of cancers (OR=1.26; 95% CI, 1.04‑1.54; P=0.020 and OR=1.33; 95% CI, 1.00‑1.75; P=0.047, respectively). However, similar associations were not found in the rs501192, rs4647297, rs507879 and rs523104 polymorphisms (all P>0.05). Results from the current meta‑analysis suggest that the rs3181320*C allele/carrier in CASP‑5 gene are potential risk factors for cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

CASP‑1, ‑2 and ‑5 gene polymorphisms and cancer risk: A review and meta‑analysis

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