Effect of heavy‑ion beam irradiation on the level of serum soluble interleukin‑2 receptors in hamster cheek pouch carcinoma model

An,Xiaoli; Li,Mingxin; Li,Na; Liu,Bin; Zhang,Hong; Wang,Jizeng

doi:10.3892/br.2014.238

May-June 2014 Volume 2 Issue 3

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May-June 2014 Volume 2 Issue 3

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Article

Effect of heavy‑ion beam irradiation on the level of serum soluble interleukin‑2 receptors in hamster cheek pouch carcinoma model

Authors:
- Xiaoli An
- Mingxin Li
- Na Li
- Bin Liu
- Hong Zhang
- Jizeng Wang
View Affiliations / Copyright

Affiliations: College of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Institute of Modern Physics, Chinese Academy of Science, Lanzhou, Gansu 730050, P.R. China, Institute of Solid Mechanics, School of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
Pages: 408-411
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Published online on: February 17, 2014

https://doi.org/10.3892/br.2014.238
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Abstract

Soluble interleukin‑2 receptor (sIL‑2R) is a glycoprotein derived from α chain of interleukin 2 receptors of mononuclear as well as T‑cell membranes. The aims of this study were to detect the changes of serum soluble interleukin‑2 receptor (sIL‑2R) levels following heavy‑ion beam irradiation in the hamster model with cheek pouch carcinoma, as well as to examine the impact of immune status of the hamster cheek pouch carcinoma model using heavy‑ion beam irradiation. sIL‑2R serum levels were detected by radioimmunoassay (RIA) in 40 hamsters bearing cheek pouch carcinoma prior to and following exposure to heavy‑ion beam irradiation, and 8 normal animals served as the control. The sIL‑2R serum level in hamster cheek pouch carcinoma model was significantly increased as compared to the normal control group (P<0.05). Results showed that an increase in the irradiation dose led to a gradual decrease in the sIL‑2R serum level. Additionally, a statistical significance was observed compared to the tumor group (P<0.05). In conclusion, alterations in serum sIL‑2R expression have an effect on the hamsters cheek pouch carcinoma model subsequent to heavy‑ion beam irradiation. An increase in the irradiation dose indicated a decreased tendency in serum sIL‑2R content. Detection of serum level changes may lead to an improved understanding of heavy‑ion irradiation in vivo immune status, which is crucial for clinical diagnosis and prognosis. It can also provide a sensitive indicator to help estimate the effects of heavy‑ion cancer targets.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of heavy‑ion beam irradiation on the level of serum soluble interleukin‑2 receptors in hamster cheek pouch carcinoma model

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