Interleukin‑1α ‑899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta‑analysis based on 19 case‑control studies

  • Authors:
    • Wan‑Fen Wang
    • Jun Shi
    • Shao‑Juan Chen
    • Yu‑Ming Niu
    • Xian‑Tao Zeng
  • View Affiliations

  • Published online on: February 19, 2014     https://doi.org/10.3892/br.2014.240
  • Pages: 378-383
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Abstract

A number of published studies investigated the association between interleukin‑1α (IL‑1α) ‑899 (+4845) C→T polymorphism and susceptibility to aggressive periodontitis (AgP). however, the results from different studies are controversial. This study was conducted to further investigate the association between IL‑1α ‑899 (+4845) C→T polymorphism and AgP using a meta‑analysis. A search was conducted through PubMed up to May 1, 2013 and a total of 19 relevant case‑control studies were identified. The results of this meta‑analysis demonstrated that IL‑1α ‑899 (+4845) C→T polymorphism is not associated with susceptibility to AgP under allele T vs. C [odds ratio (OR)=1.00, 95% confidence interval (CI): 0.88‑1.14, P=0.98; I2=28.86%] or allele A vs. C comparison (OR=0.99, 95% CI: 0.85‑1.14, P=0.85; I2=33.66%). The subgroup analyses based on ethnicity, source of controls and Hardy‑Weinberg equilibrium (HWE) also revealed no such association. There existed a weak publication bias (Egger's test P=0.02). In conclusion, based on the currently available evidence, there is no association between IL‑1α ‑899 (+4845) C→T polymorphism and susceptibility to AgP.
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May-June 2014
Volume 2 Issue 3

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Spandidos Publications style
Wang WF, Shi J, Chen SJ, Niu YM and Zeng XT: Interleukin‑1α ‑899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta‑analysis based on 19 case‑control studies. Biomed Rep 2: 378-383, 2014
APA
Wang, W., Shi, J., Chen, S., Niu, Y., & Zeng, X. (2014). Interleukin‑1α ‑899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta‑analysis based on 19 case‑control studies. Biomedical Reports, 2, 378-383. https://doi.org/10.3892/br.2014.240
MLA
Wang, W., Shi, J., Chen, S., Niu, Y., Zeng, X."Interleukin‑1α ‑899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta‑analysis based on 19 case‑control studies". Biomedical Reports 2.3 (2014): 378-383.
Chicago
Wang, W., Shi, J., Chen, S., Niu, Y., Zeng, X."Interleukin‑1α ‑899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta‑analysis based on 19 case‑control studies". Biomedical Reports 2, no. 3 (2014): 378-383. https://doi.org/10.3892/br.2014.240