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Review

Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review)

  • Authors:
    • Xiao‑Liang Lou
    • Jun Deng
    • Huan Deng
    • Yuan Ting
    • Lv Zhou
    • Yan‑Hua Liu
    • Jin‑Ping Hu
    • Xiao‑Feng Huang
    • Xiao‑Qing Qi
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330003, P.R. China, Emergency Department, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Pathology, The Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330003, P.R. China
  • Pages: 331-334
    |
    Published online on: February 27, 2014
       https://doi.org/10.3892/br.2014.242
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Abstract

Metastasis, a cascade of events beginning with epithelial‑to‑mesenchymal transition (EMT), is the main cause of cancer‑related mortality. EMT endows circulating cancer cells (CTCs) with invasive and anti‑apoptotic properties. These transitioning cells leave the primary tumor site and travel through the circulation to populate remote organs, even prior to the onset of clinical symptoms. During this journey, CTCs activate platelets, which in turn secrete α‑granules. These α‑granules contain high levels of transforming growth factor‑β (TGF‑β) and platelet‑derived growth factor (PDGF), both considered to be powerful activators of EMT. Recently, regular aspirin use was associated with a reduced risk of cancer metastasis. However, the molecular mechanism underlying the chemotherapeutic effects of aspirin on metastasis has not been fully elucidated. As platelets lack a nucleus, regular aspirin use may exert long‑lasting effects on irreversible inhibition of cyclooxygenase (COX)‑1 and, subsequently, the secretion of α‑granules, which contributes to the maintenance of the EMT state of CTCs. Thus, we hypothesized that the inhibition of platelet‑induced EMT of CTCs through the COX‑1 signaling pathway may contribute to the intriguing antimetastatic potential of aspirin.
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1 

Yu M, Ting DT, Stott SL, et al: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature. 487:510–513. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Joyce JA and Pollard JW: Microenvironmental regulation of metastasis. Nat Rev Cancer. 9:239–252. 2009. View Article : Google Scholar

3 

Deng H, Wang HF, Gao YB, Jin XL and Xiao JC: Hepatic progenitor cell represents a transitioning cell population between liver epithelium and stroma. Med Hypotheses. 76:809–812. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Chaffer CL and Weinberg RA: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Armstrong AJ, Marengo MS, Oltean S, et al: Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. Mol Cancer Res. 9:997–1007. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Bednarz N, Eltze E, Semjonow A, et al: BRCA1 loss preexisting in small subpopulations of prostate cancer is associated with advanced disease and metastatic spread to lymph nodes and peripheral blood. Clin Cancer Res. 16:3340–3348. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Joosse SA, Hannemann J, Spotter J, et al: Changes in keratin expression during metastatic progression of breast cancer: impact on the detection of circulating tumor cells. Clin Cancer Res. 18:993–1003. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Bednarz-Knoll N, Alix-Panabières C and Pantel K: Plasticity of disseminating cancer cells in patients with epithelial malignancies. Cancer Metastasis Rev. 31:673–687. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Gradilone A, Raimondi C, Nicolazzo C, et al: Circulating tumour cells lacking cytokeratin in breast cancer: the importance of being mesenchymal. J Cell Mol Med. 15:1066–1070. 2011. View Article : Google Scholar : PubMed/NCBI

10 

De Craene B and Berx G: Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 13:97–110. 2013.PubMed/NCBI

11 

Gay LJ and Felding-Habermann B: Contribution of platelets to tumour metastasis. Nat Rev Cancer. 11:123–134. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Labelle M, Begum S and Hynes RO: Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 20:576–590. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Assoian RK, Komoriya A, Meyers CA, Miller DM and Sporn MB: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 258:7155–7160. 1983.PubMed/NCBI

14 

Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R and Kasimir-Bauer S: Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res. 11:R462009. View Article : Google Scholar

15 

Bao B, Wang Z, Ali S, et al: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett. 307:26–36. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Kong D, Wang Z, Sarkar SH, et al: Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells. Stem Cells. 26:1425–1435. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Ahmad A, Wang Z, Kong D, et al: Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways. Breast Cancer Res Treat. 126:15–25. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Liu J, Liao S, Huang Y, et al: PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clin Cancer Res. 17:3638–3648. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Jechlinger M, Sommer A, Moriggl R, et al: Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest. 116:1561–1570. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Gotzmann J, Fischer AN, Zojer M, et al: A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes. Oncogene. 25:3170–3185. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Jechlinger M, Grunert S, Tamir IH, et al: Expression profiling of epithelial plasticity in tumor progression. Oncogene. 22:7155–7169. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Lahsnig C, Mikula M, Petz M, et al: ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene. 28:638–650. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Fischer AN, Fuchs E, Mikula M, Huber H, Beug H and Mikulits W: PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene. 26:3395–3405. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Bruna A, Darken RS, Rojo F, et al: High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell. 11:147–160. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Flossmann E and Rothwell PM; British Doctors Aspirin Trial and the UK-TIA Aspirin Trial. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet. 369:1603–1613. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Rothwell PM, Wilson M, Elwin CE, et al: Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 376:1741–1750. 2010.PubMed/NCBI

27 

Rothwell PM, Fowkes FG, Belch JF, Ogawa H, Warlow CP and Meade TW: Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet. 377:31–41. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Rothwell PM, Price JF, Fowkes FG, et al: Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet. 379:1602–1612. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Rothwell PM, Wilson M, Price JF, Belch JF, Meade TW and Mehta Z: Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet. 379:1591–1601. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Patrono C, Garcia Rodriguez LA, Landolfi R and Baigent C: Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med. 353:2373–2383. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Laubli H, Stevenson JL, Varki A, Varki NM and Borsig L: L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Cancer Res. 66:1536–1542. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Serebruany VL, Steinhubl SR, Berger PB, et al: Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. Am J Cardiol. 95:1218–1222. 2005. View Article : Google Scholar

33 

Peters RJ, Mehta SR, Fox KA, et al: Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Circulation. 108:1682–1687. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Topol EJ, Easton D, Harrington RA, et al: Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease. Circulation. 108:399–406. 2003. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lou XL, Deng J, Deng H, Ting Y, Zhou L, Liu YH, Hu JP, Huang XF and Qi XQ: Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review). Biomed Rep 2: 331-334, 2014.
APA
Lou, X., Deng, J., Deng, H., Ting, Y., Zhou, L., Liu, Y. ... Qi, X. (2014). Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review). Biomedical Reports, 2, 331-334. https://doi.org/10.3892/br.2014.242
MLA
Lou, X., Deng, J., Deng, H., Ting, Y., Zhou, L., Liu, Y., Hu, J., Huang, X., Qi, X."Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review)". Biomedical Reports 2.3 (2014): 331-334.
Chicago
Lou, X., Deng, J., Deng, H., Ting, Y., Zhou, L., Liu, Y., Hu, J., Huang, X., Qi, X."Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review)". Biomedical Reports 2, no. 3 (2014): 331-334. https://doi.org/10.3892/br.2014.242
Copy and paste a formatted citation
x
Spandidos Publications style
Lou XL, Deng J, Deng H, Ting Y, Zhou L, Liu YH, Hu JP, Huang XF and Qi XQ: Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review). Biomed Rep 2: 331-334, 2014.
APA
Lou, X., Deng, J., Deng, H., Ting, Y., Zhou, L., Liu, Y. ... Qi, X. (2014). Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review). Biomedical Reports, 2, 331-334. https://doi.org/10.3892/br.2014.242
MLA
Lou, X., Deng, J., Deng, H., Ting, Y., Zhou, L., Liu, Y., Hu, J., Huang, X., Qi, X."Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review)". Biomedical Reports 2.3 (2014): 331-334.
Chicago
Lou, X., Deng, J., Deng, H., Ting, Y., Zhou, L., Liu, Y., Hu, J., Huang, X., Qi, X."Aspirin inhibit platelet‑induced epithelial‑to-mesenchymal transition of circulating tumor cells (Review)". Biomedical Reports 2, no. 3 (2014): 331-334. https://doi.org/10.3892/br.2014.242
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