Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review)

Nakajima,Hideo; Koizumi,Keita

doi:10.3892/br.2014.243

Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review)

Authors:
- Hideo Nakajima
- Keita Koizumi
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Affiliations: Department of Oncology, Ageo Central General Hospital, Ageo, Saitama 362‑8588, Japan, Research Center for Child Mental Development, Kanazawa University, Kanazawa, Ishikawa 920‑8640, Japan
Published online on: February 27, 2014 https://doi.org/10.3892/br.2014.243
Pages: 321-325

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Abstract

Under conditions of acute stress, rapid adaptation is crucial for maximizing biological survival. The responses to environmental stress are often complex, involving numerous genes and integrating events at the cellular and organismal levels. The heat shock proteins (HSPs) are a family of highly conserved proteins that play critical roles in maintaining cell homeostasis and protecting cells under chronic and acute stress conditions. The genes for these stress‑responding proteins are widely distributed in organisms, tissues and cells. HSPs participate in a variety of physiological processes and are associated with various types of disease. In this review, we focused on family with sequence similarity 107 (FAM107), a novel unique protein family that exhibits functional similarity with HSPs during the cellular stress response. This review aimed to summarize the biological properties of FAM107 in cancer and the nervous system.

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