Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts

  • Authors:
    • Bing Sun
    • Xiangqian Qi
    • Jinfa Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Tongji Hospital, Tongji University, Shanghai, P.R. China, Department of Cardiology, Taida Cardiology Hospital, Tianjin, P.R. China
  • Pages: 349-353
    |
    Published online on: March 12, 2014
       https://doi.org/10.3892/br.2014.247
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Heptanol is a type of gap junction inhibitor that decreases electrical conduction velocity. However, little is known regarding the effects of heptanol on the arrhythmias induced by regional myocardial ischemia. This study aimed to investigate the effects of heptanol on ventricular arrhythmias and the underlying mechanisms. On the Langendorff apparatus, isolated hearts of Sprague-Dawley rats underwent 30 min of ischemia, with or without pretreatment with heptanol (0.1, 0.3 or 0.5 mM), 15 min prior to the induction of regional ischemia through ligation of the left anterior descending coronary artery. The incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) were recorded after ligation. Heptanol decreased the incidence of ventricular arrhythmias (45% in the control group vs. 10% in the 0.1 mM group, 0% in the 0.3 mM group and 0% in the 0.5 mM group, P<0.05), whereas it prolonged the PR interval, QT interval and monophasic action potential duration at 90% repolarization (MAPD90). As evaluated with immunofluorescence microscopy, heptanol was able to partly reverse the downregulation of connexin 43 (Cx43) induced by ischemia. The results of the reverse transcription-polymerase chain reaction were consistent with those of immunofluorescence. In conclusion, heptanol significantly decreased the incidence of VT and VF induced by regional ischemia and prolonged the PR interval, QT interval and MAPD90. Heptanol also partly reversed the downregulation of Cx43 induced by ischemia.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Qi X, Varma P, Newman D and Dorian P: Gap junction blockers decrease defibrillation thresholds without changes in ventricular refractoriness in isolated rabbit hearts. Circulation. 104:1544–1549. 2001. View Article : Google Scholar

2 

Moreno AP, Rook MB, Fishman GI and Spray DC: Gap junction channels: distinct voltage-sensitive and -insensitive conductance states. Biophys J. 67:113–119. 1994. View Article : Google Scholar : PubMed/NCBI

3 

Yu ZB and Sheng JJ: Remodeling of cardiac gap junctions and arrhythmias. Acta Physiologica Sinica. 63:586–592. 2011.(In Chinese).

4 

Delmar M and Makita N: Cardiac connexins, mutations and arrhythmias. Curr Opin Cardiol. 27:236–241. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Palatinus JA, Rhett JM and Gourdie RG: The connexin43 carboxyl terminus and cardiac gap junction organization. Biochim Biophys Acta. 1818:1831–1843. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Severs NJ, Bruce AF, Dupont E and Rothery S: Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res. 80:9–19. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Dupont E, Matsushita T, Kaba RA, et al: Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol. 33:359–371. 2001. View Article : Google Scholar

8 

Ohara T, Qu Z, Lee MH, et al: Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanol. Am J Physiol Heart Circ Physiol. 283:H1116–H1120. 2002.PubMed/NCBI

9 

Tse G, Hothi SS, Grace AA and Huang CL: Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts. J Physiol Sci. 62:79–92. 2012. View Article : Google Scholar

10 

Dorian P, Wang M, David I and Feindel C: Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model. Circulation. 83:614–621. 1991. View Article : Google Scholar : PubMed/NCBI

11 

Labhasetwar V, Underwood T, Heil RW Jr, et al: Epicardial administration of ibutilide from polyurethane matrices: effects on defibrillation threshold and electrophysiologic parameters. J Cardiovasc Pharmacol. 24:826–840. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Saffitz JE, Green KG, Kraft WJ, et al: Effects of diminished expression of connexin 43 on gap junction number and size in ventricular myocardium. Am J Physiol Heart Circ Physiol. 278:H1662–H1670. 2000.PubMed/NCBI

13 

Kwong KF, Schuessler RB, Green KG, et al: Differential expression of gap junction proteins in the canine sinus node. Circ Res. 82:604–612. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Xue Q, Ma J, et al: Effects of imidapril on heterogeneity of action potential and calcium current of ventricular myocytes in infarcted rabbits. Acta Pharmacol Sin. 25:1458–1463. 2004.PubMed/NCBI

15 

Saffitz JE and Kléber AG: Gap junctions, slow conduction, and ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 60:1111–1113. 2012.PubMed/NCBI

16 

Callans DJ, Moore EN and Spear JF: Effect of coronary perfusion of heptanol on conduction and ventricular arrhythmias in infarcted canine myocardium. J Cardiovasc Electrophysiol. 7:1159–1171. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Li F, Sugishita K, Su Z, et al: Activation of connexin-43 hemichannels can elevate [Ca2+]i and [Na+]i in rabbit ventricular myocytes during metabolic inhibition. J Mol Cell Cardiol. 33:2145–2155. 2001.PubMed/NCBI

18 

Sánchez JA, Rodríguez-Sinovas A, Fernández-Sanz C, et al: Effects of a reduction in the number of gap junction channels or in their conductance on ischemia-reperfusion arrhythmias in isolated mouse hearts. Am J Physiol Heart Circ Physiol. 301:H2442–2453. 2011.

19 

Wit AL and Peters NS: The role of gap junctions in the arrhythmias of ischemia and infarction. Heart Rhythm. 9:308–311. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun B, Qi X and Jiang J: Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts. Biomed Rep 2: 349-353, 2014.
APA
Sun, B., Qi, X., & Jiang, J. (2014). Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts. Biomedical Reports, 2, 349-353. https://doi.org/10.3892/br.2014.247
MLA
Sun, B., Qi, X., Jiang, J."Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts". Biomedical Reports 2.3 (2014): 349-353.
Chicago
Sun, B., Qi, X., Jiang, J."Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts". Biomedical Reports 2, no. 3 (2014): 349-353. https://doi.org/10.3892/br.2014.247
Copy and paste a formatted citation
x
Spandidos Publications style
Sun B, Qi X and Jiang J: Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts. Biomed Rep 2: 349-353, 2014.
APA
Sun, B., Qi, X., & Jiang, J. (2014). Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts. Biomedical Reports, 2, 349-353. https://doi.org/10.3892/br.2014.247
MLA
Sun, B., Qi, X., Jiang, J."Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts". Biomedical Reports 2.3 (2014): 349-353.
Chicago
Sun, B., Qi, X., Jiang, J."Heptanol decreases the incidence of ischemia‑induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts". Biomedical Reports 2, no. 3 (2014): 349-353. https://doi.org/10.3892/br.2014.247
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team