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Article

Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis

  • Authors:
    • Xian‑Tao Zeng
    • Jun‑Ti Lu
    • Xiang‑Jun Tang
    • Hong Weng
    • Jie Luo
  • View Affiliations / Copyright

    Affiliations: Center for Evidence‑Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
  • Pages: 432-436
    |
    Published online on: March 12, 2014
       https://doi.org/10.3892/br.2014.248
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Abstract

Several epidemiological studies suggested that methionine synthase (MTRR) rs1801394 and methionine synthase reductase (MTR) rs1805087 polymorphisms may be involved in the risk of meningioma in adults; however, the results from different case‑control studies have been inconsistent. Therefore, we performed a meta‑analysis to investigate the association of MTRR and MTR polymorphisms with meningioma. PubMed, Web of Knowledge, China National Knowledge Infrastructure and Wanfang databases were searched up to October 30, 2013 and 3 publications, involving 7 case‑control studies, were finally included. Following data extraction, a meta‑analysis was conducted using Stata 12.0 software. The pooled results based on the fixed effects model demonstrated that the MTRR rs1801394 polymorphism was associated with an increased risk of meningioma [odds ratio (OR)=1.18, 95% confidence interval (CI): 1.05‑1.32 for G vs. A; OR=1.41, 95% CI: 1.12‑1.77 for GG vs. AA; OR=1.08, 95% CI: 0.94‑1.33 for AG vs. AA; OR=1.19, 95% CI: 1.01‑1.40 for (AG+GG) vs. AA; and OR=1.32, 95% CI: 1.07‑1.63 for GG vs. (AG+AA)]; however, an association between the MTR rs1805087 polymorphism and the risk of meningioma was not identified [OR=0.99, 95% CI: 0.88‑1.12 for G vs. A; OR=1.09, 95% CI: 0.80‑1.48 for GG vs. AA; OR=0.95, 95% CI: 0.82‑1.11 for AG vs. AA; OR=0.97, 95% CI: 0.84‑1.13 for (AG+GG) vs. AA; and OR=1.09, 95% CI: 0.80‑1.48 for GG vs. (AG+AA)]. Therefore, the currently available evidence suggests that the MTRR rs1801394 polymorphism may increase the risk of meningioma, whereas the MTRR rs1801394 polymorphism is not associated with meningioma.
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Copy and paste a formatted citation
Spandidos Publications style
Zeng XT, Lu JT, Tang XJ, Weng H and Luo J: Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis. Biomed Rep 2: 432-436, 2014.
APA
Zeng, X., Lu, J., Tang, X., Weng, H., & Luo, J. (2014). Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis. Biomedical Reports, 2, 432-436. https://doi.org/10.3892/br.2014.248
MLA
Zeng, X., Lu, J., Tang, X., Weng, H., Luo, J."Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis". Biomedical Reports 2.3 (2014): 432-436.
Chicago
Zeng, X., Lu, J., Tang, X., Weng, H., Luo, J."Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis". Biomedical Reports 2, no. 3 (2014): 432-436. https://doi.org/10.3892/br.2014.248
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng XT, Lu JT, Tang XJ, Weng H and Luo J: Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis. Biomed Rep 2: 432-436, 2014.
APA
Zeng, X., Lu, J., Tang, X., Weng, H., & Luo, J. (2014). Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis. Biomedical Reports, 2, 432-436. https://doi.org/10.3892/br.2014.248
MLA
Zeng, X., Lu, J., Tang, X., Weng, H., Luo, J."Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis". Biomedical Reports 2.3 (2014): 432-436.
Chicago
Zeng, X., Lu, J., Tang, X., Weng, H., Luo, J."Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta‑analysis". Biomedical Reports 2, no. 3 (2014): 432-436. https://doi.org/10.3892/br.2014.248
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