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Review

Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review)

  • Authors:
    • Chuang Yang
    • Zhong‑Xue Fu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Third People's Hospital of Mianyang, Mianyang, Sichuan 621000, P.R. China, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing 400016, P.R. China
  • Pages: 335-339
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    Published online on: March 12, 2014
       https://doi.org/10.3892/br.2014.249
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Abstract

Oxaliplatin is effective for the treatment of advanced colorectal cancer; however, its application is restricted due to its dose‑limiting toxicity. Liposomes are sphere‑shaped vesicles consisting of one or more phospholipid bilayers. Liposomes as drug carriers are characterized by delayed release, lesion targeting and may be used as a drug-delivery system to decrease the side effects of cytotoxic drugs. Active targeting modification of liposomes may change the biological distribution of the anticancer agents, reduce or reverse multidrug resistance of tumor cells and enhance the effects of anticancer therapy. Based on the characteristics mentioned above, the aim of the present review was to demonstrate that polyethylene glycol‑liposomes containing oxaliplatin may offer advantages for the treatment of colorectal cancer in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Yang C and Fu ZX: Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review). Biomed Rep 2: 335-339, 2014.
APA
Yang, C., & Fu, Z. (2014). Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review). Biomedical Reports, 2, 335-339. https://doi.org/10.3892/br.2014.249
MLA
Yang, C., Fu, Z."Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review)". Biomedical Reports 2.3 (2014): 335-339.
Chicago
Yang, C., Fu, Z."Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review)". Biomedical Reports 2, no. 3 (2014): 335-339. https://doi.org/10.3892/br.2014.249
Copy and paste a formatted citation
x
Spandidos Publications style
Yang C and Fu ZX: Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review). Biomed Rep 2: 335-339, 2014.
APA
Yang, C., & Fu, Z. (2014). Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review). Biomedical Reports, 2, 335-339. https://doi.org/10.3892/br.2014.249
MLA
Yang, C., Fu, Z."Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review)". Biomedical Reports 2.3 (2014): 335-339.
Chicago
Yang, C., Fu, Z."Liposomal delivery and polyethylene glycol‑liposomal oxaliplatin for the treatment of colorectal cancer (Review)". Biomedical Reports 2, no. 3 (2014): 335-339. https://doi.org/10.3892/br.2014.249
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