Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression

  • Authors:
    • Fang Yang
    • Fenxia Chen
    • Jun Gu
    • Wenwen Zhang
    • Jiayan Luo
    • Xiaoxiang Guan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, P.R. China, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, P.R. China
  • Pages: 404-407
    |
    Published online on: March 14, 2014
       https://doi.org/10.3892/br.2014.254
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The GATA binding protein 3 (GATA3) is a member of a family of 6 GATA dual zinc finger transcription factors (GATA1‑6), which are required for the development and morphogenesis of the mammary gland. GATA3 is considered to play a dual role in oncogenesis and cancer development, whereas somatic GATA3 mutations have been reported in breast cancer. variants of the GATA3 genetic 3' untranslated region (3'UTR) microRNA (miRNA) binding sites have been associated with breast cancer risk. However, the roles of genetic variants in the GATA3 gene 3'UTR and its post‑transcriptional regulation have not been fully elucidated. We discovered that rs1058240 in the GATA3 3'UTR displayed potential miRNA binding sites and this variant was found to be significantly associated with GATA3 mRNA expression (P=2.36E‑07), suggesting that rs1058240 may be a putative variant mediating the post‑transcriptional regulation of the GATA3 target gene. Further studies investigating the regulatory mechanism of GATA3 transcriptional activity are required to design novel strategies against breast cancer cell growth and differentiation.
View Figures

Figure 1

Figure 2

View References

1 

Merika M and Orkin SH: DNA-binding specificity of GATA family transcription factors. Mol Cell Biol. 13:3999–4010. 1993.PubMed/NCBI

2 

Joulin V, Bories D, Eleouet JF, Labastie MC, Chretien S, Mattei MG and Romeo PH: A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 10:1809–1816. 1991.PubMed/NCBI

3 

Asselin-Labat ML, Sutherland KD, Barker H, et al: Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol. 9:201–209. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Lim KC, Lakshmanan G, Crawford SE, Gu Y, Grosveld F and Engel JD: Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet. 25:209–212. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Grigorieva IV, Mirczuk S, Gaynor KU, et al: Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest. 120:2144–2155. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Grote D, Souabni A, Busslinger M and Bouchard M: Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. 133:53–61. 2006. View Article : Google Scholar : PubMed/NCBI

7 

van der Wees J, van Looij MA, de Ruiter MM, et al: Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder. Neurobiol Dis. 16:169–178. 2004.PubMed/NCBI

8 

Kaufman CK, Zhou P, Pasolli HA, et al: GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev. 17:2108–2122. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Ting CN, Olson MC, Barton KP and Leiden JM: Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:474–478. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Kouros-Mehr H, Slorach EM, Sternlicht MD and Werb Z: GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. 127:1041–1055. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Voduc D, Cheang M and Nielsen T: GATA-3 expression in breast cancer has a strong association with estrogen receptor but lacks independent prognostic value. Cancer Epidemiol Biomarkers Prev. 17:365–373. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Parikh P, Palazzo JP, Rose LJ, Daskalakis C and Weigel RJ: GATA-3 expression as a predictor of hormone response in breast cancer. J Am Coll Surg. 200:705–710. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Fang SH, Chen Y and Weigel RJ: GATA-3 as a marker of hormone response in breast cancer. J Surg Res. 157:290–295. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Bong PN, Zakaria Z, Muhammad R, et al: Expression and mutational analysis of GATA3 in Malaysian breast carcinomas. Malays J Pathol. 32:117–122. 2010.PubMed/NCBI

15 

Mehra R, Varambally S, Ding L, et al: Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis. Cancer Res. 65:11259–11264. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar

17 

Chou J, Lin JH, Brenot A, Kim JW, Provot S and Werb Z: GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 15:201–213. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Holm K, Melum E, Franke A and Karlsen TH: SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels. BMC Bioinformatics. 11:6002010. View Article : Google Scholar : PubMed/NCBI

19 

Stranger BE, Forrest MS, Dunning M, et al: Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science. 315:848–853. 2007. View Article : Google Scholar : PubMed/NCBI

20 

International HapMap Consortium. The International HapMap Project. Nature. 426:789–796. 2003. View Article : Google Scholar

21 

Usary J, Llaca V, Karaca G, et al: Mutation of GATA3 in human breast tumors. Oncogene. 23:7669–7678. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Banerji S, Cibulskis K, Rangel-Escareno C, et al: Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 486:405–409. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Gaynor KU, Grigorieva IV, Allen MD, et al: GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness. Horm Cancer. 4:123–139. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Bockhorn J, Dalton R, Nwachukwu C, et al: MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun. 4:13932013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang F, Chen F, Gu J, Zhang W, Luo J and Guan X: Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression. Biomed Rep 2: 404-407, 2014.
APA
Yang, F., Chen, F., Gu, J., Zhang, W., Luo, J., & Guan, X. (2014). Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression. Biomedical Reports, 2, 404-407. https://doi.org/10.3892/br.2014.254
MLA
Yang, F., Chen, F., Gu, J., Zhang, W., Luo, J., Guan, X."Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression". Biomedical Reports 2.3 (2014): 404-407.
Chicago
Yang, F., Chen, F., Gu, J., Zhang, W., Luo, J., Guan, X."Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression". Biomedical Reports 2, no. 3 (2014): 404-407. https://doi.org/10.3892/br.2014.254
Copy and paste a formatted citation
x
Spandidos Publications style
Yang F, Chen F, Gu J, Zhang W, Luo J and Guan X: Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression. Biomed Rep 2: 404-407, 2014.
APA
Yang, F., Chen, F., Gu, J., Zhang, W., Luo, J., & Guan, X. (2014). Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression. Biomedical Reports, 2, 404-407. https://doi.org/10.3892/br.2014.254
MLA
Yang, F., Chen, F., Gu, J., Zhang, W., Luo, J., Guan, X."Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression". Biomedical Reports 2.3 (2014): 404-407.
Chicago
Yang, F., Chen, F., Gu, J., Zhang, W., Luo, J., Guan, X."Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression". Biomedical Reports 2, no. 3 (2014): 404-407. https://doi.org/10.3892/br.2014.254
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team