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Article

Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain

  • Authors:
    • Chuan Yin Hu
    • Yun‑Tao Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Guangdong Medical College, Zhanjiang, Guangdong 524023, P.R. China, Modern Biochemistry Center, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China
  • Pages: 569-573
    |
    Published online on: March 31, 2014
       https://doi.org/10.3892/br.2014.267
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Abstract

Naringenin, a flavonoid abundant in citrus fruits, such as grapefruits, has been reported to possess anti‑inflammatory properties. The present study aimed to investigate the analgesic potential of naringenin in L5 spinal nerve ligation (SNL)‑induced peripheral neuropathic pain and the underlying mechanisms associated with neuroinflammation. Different doses of naringenin or saline were administered intrathecally once daily for 11 consecutive days, from 3 days prior to surgery to 7 days after surgery. Pain development was assessed 1 day prior to and 7‑14 days after surgery in terms of mechanical withdrawal threshold and thermal withdrawal latency. Astrocytic and microglial activation and production of inflammatory mediators were determined on day 14 after surgery. The results demonstrated that naringenin dose‑dependently attenuated the mechanical allodynia and thermal hyperalgesia induced by SNL. Furthermore, naringenin significantly inhibited SNL‑induced activation of glial cells (astrocytes and microglia). Morover, the upregulated expression of inflammatory mediators in neuropathic pain was significantly inhibited by naringenin. Our findings suggested that repeated administration of naringenin may alleviate neuropathic pain, possibly through inhibiting neuroinflammation.
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1 

Jha MK, Jeon S and Suk K: Glia as a link between neuroinflammation and neuropathic pain. Immune Netw. 12:41–47. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Kiguchi N, Kobayashi Y and Kishioka S: Chemokines and cytokines in neuroinflammation leading to neuropathic pain. Curr Opin Pharmacol. 12:55–61. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Ren K and Dubner R: Interactions between the immune and nervous systems in pain. Nat Med. 16:1267–1276. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Milligan ED and Watkins LR: Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci. 10:23–36. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Hare JT and Elliott DP: Grapefruit juice and potential drug interactions. Consult Pharm. 18:466–472. 2003.PubMed/NCBI

6 

Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI and Dexter DT: Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson’s disease. Free Radic Res. 39:1119–1125. 2005.PubMed/NCBI

7 

Kanno S, Shouji A, Tomizawa A, Hiura T, Osanai Y, Ujibe M, Obara Y, Nakahata N and Ishikawa M: Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. Life Sci. 78:673–681. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Bodet C, La VD, Epifano F and Grenier D: Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models. J Periodontal Res. 43:400–407. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Park HY, Kim GY and Choi YH: Naringenin attenuates the release of pro-inflammatory mediators from lipopolysaccharide-stimulated BV2 microglia by inactivating nuclear factor-κB and inhibiting mitogen-activated protein kinases. Int J Mol Med. 30:204–210. 2012.PubMed/NCBI

10 

Shiratori K, Ohgami K, Ilieva I, Jin XH, Yoshida K, Kase S and Ohno S: The effects of naringin and naringenin on endotoxin-induced uveitis in rats. J Ocul Pharmacol Ther. 21:298–304. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Wang D, Gao K, Li X, Shen X, Zhang X, Ma C, Qin C and Zhang L: Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer’s disease. Pharmacol Biochem Behav. 102:13–20. 2012.PubMed/NCBI

12 

Golechha M, Chaudhry U, Bhatia J, Saluja D and Arya DS: Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol Pharm Bull. 34:360–365. 2011. View Article : Google Scholar

13 

Kumar P and Kumar A: Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington’s like symptoms in rats: possible role of nitric oxide. Behav Brain Res. 206:38–46. 2010.PubMed/NCBI

14 

Kandhare AD, Raygude KS, Ghosh P, Ghule AE and Bodhankar SL: Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia. 83:650–659. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Kim SH and Chung JM: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:355–363. 1992. View Article : Google Scholar

16 

Feng X, Zhang F, Dong R, Li W, Liu J, Zhao X, Xue Q, Yu B and Xu J: Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia. Eur J Pharmacol. 614:38–43. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Morgenweck J, Griggs RB, Donahue RR, Zadina JE and Taylor BK: PPARgamma activation blocks development and reduces established neuropathic pain in rats. Neuropharmacology. 70:236–246. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Chen Y, Willcockson HH and Valtschanoff JG: Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain. Exp Neurol. 220:383–390. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Reichling DB and Levine JD: Critical role of nociceptor plasticity in chronic pain. Trends Neurosci. 32:611–618. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Schomberg D and Olson JK: Immune responses of microglia in the spinal cord: contribution to pain states. Exp Neurol. 234:262–270. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu CY and Zhao YT: Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain. Biomed Rep 2: 569-573, 2014.
APA
Hu, C.Y., & Zhao, Y. (2014). Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain. Biomedical Reports, 2, 569-573. https://doi.org/10.3892/br.2014.267
MLA
Hu, C. Y., Zhao, Y."Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain". Biomedical Reports 2.4 (2014): 569-573.
Chicago
Hu, C. Y., Zhao, Y."Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain". Biomedical Reports 2, no. 4 (2014): 569-573. https://doi.org/10.3892/br.2014.267
Copy and paste a formatted citation
x
Spandidos Publications style
Hu CY and Zhao YT: Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain. Biomed Rep 2: 569-573, 2014.
APA
Hu, C.Y., & Zhao, Y. (2014). Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain. Biomedical Reports, 2, 569-573. https://doi.org/10.3892/br.2014.267
MLA
Hu, C. Y., Zhao, Y."Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain". Biomedical Reports 2.4 (2014): 569-573.
Chicago
Hu, C. Y., Zhao, Y."Analgesic effects of naringenin in rats with spinal nerve ligation‑induced neuropathic pain". Biomedical Reports 2, no. 4 (2014): 569-573. https://doi.org/10.3892/br.2014.267
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