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Article

CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis

  • Authors:
    • Li Wen
    • Yuan‑Yuan Hu
    • Gong‑Li Yang
    • De‑Xi Liu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, P.R. China, Department of Stomatology and Evidence‑Based Medicine Center, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, P.R. China, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Baiyun, Guangzhou 510515, P.R. China
  • Pages: 549-554
    |
    Published online on: May 21, 2014
       https://doi.org/10.3892/br.2014.286
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Abstract

The common functional cyclin D1 (CCND1) G870A polymorphism may influence the risk of esophageal cancer. However, the conclusions of previous studies have been inconsistent for the association between the CCND1 G870A polymorphism and esophageal cancer risk. A meta?analysis of 11 published case?control studies was performed, including 2,111 patients with esophageal cancer and 3,232 controls, to investigate the association between the CCND1 G870A polymorphism and esophageal cancer risk. The odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between the CCND1 G870A polymorphism and esophageal cancer risk. A significant association between the CCND1 G870A polymorphism and esophageal cancer risk was observed for the allele contrast (A vs. G: OR, 1.23; 95% CI, 1.02?1.48; P=0.029), codominant (AA vs. GG: OR, 1.58; 95% CI; 1.06?2.35; P=0.024) and recessive models (AA vs. GG + GA: OR, 1.33, 95% CI, 1.03?1.73; P=0.030). However, in the stratified analysis by ethnicity, study design and pathology, there was no significant association detected in these genetic models. In conclusion, results of the meta?analy­sis suggested that the CCND1 G870A polymorphism is a potential risk factor in the development of esophageal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wen L, Hu YY, Yang GL and Liu DX: CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis. Biomed Rep 2: 549-554, 2014.
APA
Wen, L., Hu, Y., Yang, G., & Liu, D. (2014). CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis. Biomedical Reports, 2, 549-554. https://doi.org/10.3892/br.2014.286
MLA
Wen, L., Hu, Y., Yang, G., Liu, D."CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis". Biomedical Reports 2.4 (2014): 549-554.
Chicago
Wen, L., Hu, Y., Yang, G., Liu, D."CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis". Biomedical Reports 2, no. 4 (2014): 549-554. https://doi.org/10.3892/br.2014.286
Copy and paste a formatted citation
x
Spandidos Publications style
Wen L, Hu YY, Yang GL and Liu DX: CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis. Biomed Rep 2: 549-554, 2014.
APA
Wen, L., Hu, Y., Yang, G., & Liu, D. (2014). CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis. Biomedical Reports, 2, 549-554. https://doi.org/10.3892/br.2014.286
MLA
Wen, L., Hu, Y., Yang, G., Liu, D."CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis". Biomedical Reports 2.4 (2014): 549-554.
Chicago
Wen, L., Hu, Y., Yang, G., Liu, D."CCND1 G870A polymorphism contributes to the risk of esophageal cancer: An updated systematic review and cumulative meta?analysis". Biomedical Reports 2, no. 4 (2014): 549-554. https://doi.org/10.3892/br.2014.286
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