Heat?shock protein 70?2 BB genotype is associated with reduced risks of the steroid?dependent and refractory phenotypes of ulcerative colitis

Tahara,Tomomitsu; Shibata,Tomoyuki; Okubo,Masaaki; Ishizuka,Takamitsu; Kawamura,Tomohiko; Yamashita,Hiromi; Nakamura,Masakatsu; Nakagawa,Yoshihito; Nagasaka,Mitsuo; Arisawa,Tomiyasu; Ohmiya,Naoki; Hirata,Ichiro

doi:10.3892/br.2014.288

Heat?shock protein 70?2 BB genotype is associated with reduced risks of the steroid?dependent and refractory phenotypes of ulcerative colitis

Authors:
- Tomomitsu Tahara
- Tomoyuki Shibata
- Masaaki Okubo
- Takamitsu Ishizuka
- Tomohiko Kawamura
- Hiromi Yamashita
- Masakatsu Nakamura
- Yoshihito Nakagawa
- Mitsuo Nagasaka
- Tomiyasu Arisawa
- Naoki Ohmiya
- Ichiro Hirata
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Affiliations: Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi 470‑1192, Japan, Department of Gastroenterology, Kanzawa Medical University, Uchinada‑machi, Ishikawa‑ken 920‑0292, Japan
Published online on: May 21, 2014 https://doi.org/10.3892/br.2014.288
Pages: 555-558

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Abstract

Previous studies have demonstrated the protective role of inducible heat?shock protein (HSP) 70 in intestinal cells. The HSP70?2 gene has a PstI site due to an A?G transition at the 1,267 position and different genotypes are associated with various levels of mRNA expression. The present study aimed to clarify the effect of the HSP70?2 polymorphism on the risk of ulcerative colitis (UC), including its clinical phenotypes. A total of 121 patients with UC and 500 healthy control (HC) subjects participated in the study. To assess the polymorphisms at the 1,267 position of the HSP70?2 gene, restriction fragment length polymorphism analysis was performed. The subjects in the study were classified by disease behavior, severity and extent of disease. Although no significant difference of the HSP70?2 genotype distribution was identified between the HC and UC groups, the BB genotype exhibited a lower risk of the steroid?dependent phenotype [odds ratio (OR), 0.12; 95% confidence interval (CI), 0.02?0.95; P=0.02]. The same genotype was also associated with a lower risk of the refractory phenotype (OR, 0.16; 95% CI, 0.04?0.73; P=0.01). There was no direct correlation between the polymorphism of the HSP70?2 gene and UC susceptibility. However, there was an association between a reduced risk of the steroid?dependent and refractory phenotypes of UC and the BB genotype.

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