Anti?inflammatory effects of ozonated water in an experimental mouse model

  • Authors:
    • Kazuo Azuma
    • Takuro Mori
    • Kinya Kawamoto
    • Kohei Kuroda
    • Takeshi Tsuka
    • Tomohiro Imagawa
    • Tomohiro Osaki
    • Fumio Itoh
    • Saburo Minami
    • Yoshiharu Okamoto
  • View Affiliations

  • Published online on: May 26, 2014     https://doi.org/10.3892/br.2014.290
  • Pages: 671-674
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Abstract

Previous studies have suggested that ozonated water is safe and possesses antibacterial effects for treatment of experimental peritonitis rats. In this study, we evaluated the anti?inflammatory effects of ozonated water that was intraperitoneally injected into an experimental inflammatory mouse model. The concentrations of dissolved ozone decreased constantly and lineally, while the half?life of dissolved ozone was 36.8±2.7 min (27?C). The 10?ppm ozonated water was injected intraperitoneally into mice with lipopolysaccharide (LPS)?induced acute inflammation. The results showed that the intraperitoneal injection of ozonated water decreased the levels of tumor necrosis factor?? (TNF??) and increased the activity of superoxide dismutase (SOD). The results suggest that ozonated water has anti?inflammatory properties and is a potential therapeutic option for acute inflammation.
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September-October 2014
Volume 2 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Azuma K, Mori T, Kawamoto K, Kuroda K, Tsuka T, Imagawa T, Osaki T, Itoh F, Minami S, Okamoto Y, Okamoto Y, et al: Anti?inflammatory effects of ozonated water in an experimental mouse model. Biomed Rep 2: 671-674, 2014
APA
Azuma, K., Mori, T., Kawamoto, K., Kuroda, K., Tsuka, T., Imagawa, T. ... Okamoto, Y. (2014). Anti?inflammatory effects of ozonated water in an experimental mouse model. Biomedical Reports, 2, 671-674. https://doi.org/10.3892/br.2014.290
MLA
Azuma, K., Mori, T., Kawamoto, K., Kuroda, K., Tsuka, T., Imagawa, T., Osaki, T., Itoh, F., Minami, S., Okamoto, Y."Anti?inflammatory effects of ozonated water in an experimental mouse model". Biomedical Reports 2.5 (2014): 671-674.
Chicago
Azuma, K., Mori, T., Kawamoto, K., Kuroda, K., Tsuka, T., Imagawa, T., Osaki, T., Itoh, F., Minami, S., Okamoto, Y."Anti?inflammatory effects of ozonated water in an experimental mouse model". Biomedical Reports 2, no. 5 (2014): 671-674. https://doi.org/10.3892/br.2014.290