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Article

Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat

  • Authors:
    • Min Yang
    • Juan Ding
    • Xu Zhou
    • Xuehong Zhang
    • Hong Tao
    • Yin Wang
    • Guanghua Li
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Pediatrics, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China
  • Pages: 687-692
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    Published online on: May 26, 2014
       https://doi.org/10.3892/br.2014.291
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Abstract

The purpose of the present study was to investigate the effects of high ambient temperature on the neuropeptide Y (NPY) mRNA level in the hypothalamus, the plasma concentration of corticotropin?releasing hormone (CRH), cortisol (Cor), heat?shock protein 70 (HSP70) and epinephrine (EPI), and the intervention of lycium barbarum polysaccharides (LBPs) in rats. Compared to the control (CN) group, the plasma levels of CRH, Cor, HSP70 and EPI were markedly increased, and the level of NPY mRNA was downregulated in the high ambient temperature (HT) group. By contrast, rats in the HT + LBP (HTL) group had: i) a significantly enhanced expression of HSP70 compared to the HT and CN groups; ii) clearly increased plasma levels of CRH, Cor and EPI compared to the CN group; and iii) a markedly upregulated expression of NPY mRNA compared to the HT group. Thus, the results showed that high?temperature environments may damage the body, and LBPs have a potentially protective function by increasing the expression of HSP70 and NPY.
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Spandidos Publications style
Yang M, Ding J, Zhou X, Zhang X, Tao H, Wang Y and Li G: Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat. Biomed Rep 2: 687-692, 2014.
APA
Yang, M., Ding, J., Zhou, X., Zhang, X., Tao, H., Wang, Y., & Li, G. (2014). Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat. Biomedical Reports, 2, 687-692. https://doi.org/10.3892/br.2014.291
MLA
Yang, M., Ding, J., Zhou, X., Zhang, X., Tao, H., Wang, Y., Li, G."Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat". Biomedical Reports 2.5 (2014): 687-692.
Chicago
Yang, M., Ding, J., Zhou, X., Zhang, X., Tao, H., Wang, Y., Li, G."Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat". Biomedical Reports 2, no. 5 (2014): 687-692. https://doi.org/10.3892/br.2014.291
Copy and paste a formatted citation
x
Spandidos Publications style
Yang M, Ding J, Zhou X, Zhang X, Tao H, Wang Y and Li G: Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat. Biomed Rep 2: 687-692, 2014.
APA
Yang, M., Ding, J., Zhou, X., Zhang, X., Tao, H., Wang, Y., & Li, G. (2014). Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat. Biomedical Reports, 2, 687-692. https://doi.org/10.3892/br.2014.291
MLA
Yang, M., Ding, J., Zhou, X., Zhang, X., Tao, H., Wang, Y., Li, G."Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat". Biomedical Reports 2.5 (2014): 687-692.
Chicago
Yang, M., Ding, J., Zhou, X., Zhang, X., Tao, H., Wang, Y., Li, G."Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat". Biomedical Reports 2, no. 5 (2014): 687-692. https://doi.org/10.3892/br.2014.291
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