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Review

Neuroprotection of microRNA in neurological disorders (Review)

  • Authors:
    • Chunmei Wang
    • Bingyuan Ji
    • Baohua Cheng
    • Jing Chen
    • Bo Bai
  • View Affiliations / Copyright

    Affiliations: Neurobiology Institute, Jining Medical University, Jining 272067, P.R. China
  • Pages: 611-619
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    Published online on: June 16, 2014
       https://doi.org/10.3892/br.2014.297
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Abstract

MicroRNAs (miRNAs) are small, endogenous, non‑coding RNA molecules that function as post‑transcriptional regulators of gene expression by imperfect base‑pairing with the 3'‑untranslated regions of their target mRNAs. Altered expression of numerous miRNAs has been shown to be extensively involved in the pathogenesis of various diseases and cancers. Additionally, the specific expression of miRNAs in the nervous system has indicated that miRNAs are critical for the occurrence and development of neurological diseases. Increasing evidence has shown that specific miRNAs target the expression of particular proteins that are significant in the disease pathogenesis. Therefore, miRNA‑mediated regulation may be important in the occurrence and development of neurological diseases and may function as a novel biomarker and tool for clinical therapy. In the present study, the significance of miRNAs is reviewed in a number of neurological disorders and the possibility of their use in therapeutic interventions is evaluated.
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1 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ and Srivastava D: Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 129:303–317. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Carleton M, Cleary MA and Linsley PS: MicroRNAs and cell cycle regulation. Cell Cycle. 6:2127–2132. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T and Takahashi T: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64:3753–3756. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Guo J, Miao Y, Xiao B, Huan R, Jiang Z, Meng D and Wang Y: Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. J Gastroenterol Hepatol. 24:652–657. 2009. View Article : Google Scholar : PubMed/NCBI

6 

van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA and Olson EN: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA. 103:18255–18260. 2006.PubMed/NCBI

7 

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Ménard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M and Croce CM: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Yoon SO, Chun SM, Han EH, Choi J, Jang SJ, Koh SA, Hwang S and Yu E: Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma. Hum Pathol. 42:1391–1400

9 

Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F and Croce CM: Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 99:15524–15529. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E and Ambros V: Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 5:R132004. View Article : Google Scholar

11 

Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W and Tuschl T: Identification of tissue-specific microRNAs from mouse. Curr Biol. 12:735–739. 2002. View Article : Google Scholar : PubMed/NCBI

12 

He X, Zhang Q, Liu Y and Pan X: Cloning and identification of novel microRNAs from rat hippocampus. Acta Biochim Biophys Sin (Shanghai). 39:708–714. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Natera-Naranjo O, Aschrafi A, Gioio AE and Kaplan BB: Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons. RNA. 16:1516–1529. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Nudelman AS, DiRocco DP, Lambert TJ, Garelick MG, Le J, Nathanson NM and Storm DR: Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. Hippocampus. 20:492–498. 2010.PubMed/NCBI

15 

Sano T, Reynolds JP, Jimenez-Mateos EM, Matsushima S, Taki W and Henshall DC: MicroRNA-34a upregulation during seizure-induced neuronal death. Cell Death Dis. 3:e2872012. View Article : Google Scholar : PubMed/NCBI

16 

Dirnagl U, Becker K and Meisel A: Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol. 8:398–412. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Dhodda VK, Sailor KA, Bowen KK and Vemuganti R: Putative endogenous mediators of preconditioning-induced ischemic tolerance in rat brain identified by genomic and proteomic analysis. J Neurochem. 89:73–89. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Dharap A and Vemuganti R: Ischemic pre-conditioning alters cerebral microRNAs that are upstream to neuroprotective signaling pathways. J Neurochem. 113:1685–1691. 2010.PubMed/NCBI

19 

Lee ST, Chu K, Jung KH, Yoon HJ, Jeon D, Kang KM, Park KH, Bae EK, Kim M, Lee SK and Roh JK: MicroRNAs induced during ischemic preconditioning. Stroke. 41:1646–1651. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Lusardi TA, Farr CD, Faulkner CL, Pignataro G, Yang T, Lan J, Simon RP and Saugstad JA: Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex. J Cereb Blood Flow Metab. 30:744–756. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Dharap A, Bowen K, Place R, Li LC and Vemuganti R: Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab. 29:675–687. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Yin KJ, Deng Z, Huang H, Hamblin M, Xie C, Zhang J and Chen YE: miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiol Dis. 38:17–26. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Pandi G, Nakka VP, Dharap A, Roopra A and Vemuganti R: MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. PLoS One. 8:e580392013. View Article : Google Scholar : PubMed/NCBI

24 

Xu WH, Yao XY, Yu HJ, Huang JW and Cui LY: Downregulation of miR-199a may play a role in 3-nitropropionic acid induced ischemic tolerance in rat brain. Brain Res. 1429:116–123. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R and Rajewsky N: Widespread changes in protein synthesis induced by microRNAs. Nature. 455:58–63. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Ricarte Filho JC and Kimura ET: MicroRNAs: novel class of gene regulators involved in endocrine function and cancer. Arq Bras Endocrinol Metabol. 50:1102–1107. 2006.PubMed/NCBI

27 

Hu JR, Lv GH and Yin BL: Altered microRNA expression in the ischemic-reperfusion spinal cord with atorvastatin therapy. J Pharmacol Sci. 121:343–346. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M and Croce CM: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA. 102:13944–13949. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Cao L, Feng C, Li L and Zuo Z: Contribution of microRNA-203 to the isoflurane preconditioning-induced neuroprotection. Brain Res Bull. 88:525–528. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Kocerha J, Kauppinen S and Wahlestedt C: microRNAs in CNS disorders. Neuromolecular Med. 11:162–172. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, Wang CW and Jeyaseelan K: Expression profile of MicroRNAs in young stroke patients. PLoS One. 4:e76892009. View Article : Google Scholar : PubMed/NCBI

32 

Tan JR, Tan KS, Koo YX, Yong FL, Wang CW, Armugam A and Jeyaseelan K: Blood microRNAs in low or no risk ischemic stroke patients. Int J Mol Sci. 14:2072–2084. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Siegel C, Li J, Liu F, Benashski SE and McCullough LD: miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia. Proc Natl Acad Sci USA. 108:11662–11667. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Harraz MM, Eacker SM, Wang X, Dawson TM and Dawson VL: MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proc Natl Acad Sci USA. 109:18962–18967. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Witwer KW, Sisk JM, Gama L and Clements JE: MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response. J Immunol. 184:2369–2376. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Selvamani A, Sathyan P, Miranda RC and Sohrabji F: An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS One. 7:e326622012. View Article : Google Scholar : PubMed/NCBI

37 

Buller B, Liu X, Wang X, Zhang RL, Zhang L, Hozeska-Solgot A, Chopp M and Zhang ZG: MicroRNA-21 protects neurons from ischemic death. FEBS J. 277:4299–4307. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Ouyang YB, Lu Y, Yue S, Xu LJ, Xiong XX, White RE, Sun X and Giffard RG: miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo. Neurobiol Dis. 45:555–563. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Liu XS, Chopp M, Zhang RL, Tao T, Wang XL, Kassis H, Hozeska-Solgot A, Zhang L, Chen C and Zhang ZG: MicroRNA profiling in subventricular zone after stroke: MiR-124a regulates proliferation of neural progenitor cells through Notch signaling pathway. PLoS One. 6:e234612011. View Article : Google Scholar : PubMed/NCBI

40 

Zeng L, Liu J, Wang Y, Wang L, Weng S, Tang Y, Zheng C, Cheng Q, Chen S and Yang GY: MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia. Front Biosci (Elite Ed). 3:1265–1272. 2011.PubMed/NCBI

41 

Rink C and Khanna S: MicroRNA in ischemic stroke etiology and pathology. Physiol Genomics. 43:521–528. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Eacker SM, Dawson TM and Dawson VL: Understanding microRNAs in neurodegeneration. Nat Rev Neurosci. 10:837–841. 2009.PubMed/NCBI

43 

Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A and De Strooper B: Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci USA. 105:6415–6420. 2008.PubMed/NCBI

44 

Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C, Prinjha RK, Richardson JC, Saunders AM, Roses AD and Richards CA: Identification of miRNA changes in Alzheimer’s disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis. 14:27–41. 2008.

45 

Boissonneault V, Plante I, Rivest S and Provost P: MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem. 284:1971–1981. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I and Nelson PT: The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci. 28:1213–1223. 2008.PubMed/NCBI

47 

Patel N, Hoang D, Miller N, Ansaloni S, Huang Q, Rogers JT, Lee JC and Saunders AJ: MicroRNAs can regulate human APP levels. Mol Neurodegener. 3:102008. View Article : Google Scholar : PubMed/NCBI

48 

Lukiw WJ, Zhao Y and Cui JG: An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem. 283:31315–31322. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Croce N, Gelfo F, Ciotti MT, Federici G, Caltagirone C, Bernardini S and Angelucci F: NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection? Mol Cell Biochem. 376:189–195. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Harraz MM, Dawson TM and Dawson VL: MicroRNAs in Parkinson’s disease. J Chem Neuroanat. 42:127–130. 2011.

51 

Mouradian MM: MicroRNAs in Parkinson’s disease. Neurobiol Dis. 46:279–284. 2012.

52 

Doxakis E: Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153. J Biol Chem. 285:12726–12734. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Martins M, Rosa A, Guedes LC, Fonseca BV, Gotovac K, Violante S, Mestre T, Coelho M, Rosa MM, Martin ER, Vance JM, Outeiro TF, Wang L, Borovecki F, Ferreira JJ and Oliveira SA: Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson’s disease. PLoS One. 6:e254432011.

54 

Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G and Abeliovich A: A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 317:1220–1224. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Wang G, van der Walt JM, Mayhew G, Li YJ, Züchner S, Scott WK, Martin ER and Vance JM: Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet. 82:283–289. 2008. View Article : Google Scholar : PubMed/NCBI

56 

Margis R, Margis R and Rieder CR: Identification of blood microRNAs associated to Parkinson’s disease. J Biotechnol. 152:96–101. 2011.

57 

Packer AN, Xing Y, Harper SQ, Jones L and Davidson BL: The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington’s disease. J Neurosci. 28:14341–14346. 2008.PubMed/NCBI

58 

Lee ST, Chu K, Im WS, Yoon HJ, Im JY, Park JE, Park KH, Jung KH, Lee SK, Kim M and Roh JK: Altered microRNA regulation in Huntington’s disease models. Exp Neurol. 227:172–179. 2011.

59 

Zuccato C, Belyaev N, Conforti P, Ooi L, Tartari M, Papadimou E, MacDonald M, Fossale E, Zeitlin S, Buckley N and Cattaneo E: Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington’s disease. J Neurosci. 27:6972–6983. 2007.PubMed/NCBI

60 

Seredenina T, Gokce O and Luthi-Carter R: Decreased striatal RGS2 expression is neuroprotective in Huntington’s disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation. PLoS One. 6:e222312011.

61 

Landles C and Bates GP: Huntingtin and the molecular pathogenesis of Huntington’s disease. Fourth in molecular medicine review series. EMBO Rep. 5:958–963. 2004.

62 

Jovicic A, Zaldivar Jolissaint JF, Moser R, Silva Santos Mde F and Luthi-Carter R: MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington’s disease-related mechanisms. PLoS One. 8:e542222013.PubMed/NCBI

63 

Christensen M, Larsen LA, Kauppinen S and Schratt G: Recombinant adeno-associated virus-mediated microRNA delivery into the postnatal mouse brain reveals a role for miR-134 in dendritogenesis in vivo. Front Neural Circuits. 3:162010.PubMed/NCBI

64 

Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC and Tsai LH: A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 466:1105–1109. 2010. View Article : Google Scholar : PubMed/NCBI

65 

Hu K, Xie YY, Zhang C, Ouyang DS, Long HY, Sun DN, Long LL, Feng L, Li Y and Xiao B: MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus. BMC Neurosci. 13:1152012. View Article : Google Scholar : PubMed/NCBI

66 

Kan AA, van Erp S, Derijck AA, de Wit M, Hessel EV, O’Duibhir E, de Jager W, Van Rijen PC, Gosselaar PH, de Graan PN and Pasterkamp RJ: Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cell Mol Life Sci. 69:3127–3145. 2012. View Article : Google Scholar : PubMed/NCBI

67 

Peng J, Omran A, Ashhab MU, Kong H, Gan N, He F and Yin F: Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy. J Mol Neurosci. 50:291–297. 2013. View Article : Google Scholar : PubMed/NCBI

68 

Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, Engel T, McKiernan RC, Mouri G, Tanaka K, Sano T, Saugstad JA, Simon RP, Stallings RL and Henshall DC: miRNA expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. Am J Pathol. 179:2519–2532. 2011. View Article : Google Scholar : PubMed/NCBI

69 

Redell JB, Liu Y and Dash PK: Traumatic brain injury alters expression of hippocampal microRNAs: potential regulators of multiple pathophysiological processes. J Neurosci Res. 87:1435–1448. 2009. View Article : Google Scholar

70 

Redell JB, Zhao J and Dash PK: Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. J Neurosci Res. 89:212–221. 2011. View Article : Google Scholar : PubMed/NCBI

71 

Jee MK, Jung JS, Im YB, Jung SJ and Kang SK: Silencing of miR20a is crucial for Ngn1-mediated neuroprotection in injured spinal cord. Hum Gene Ther. 23:508–520. 2012. View Article : Google Scholar : PubMed/NCBI

72 

Jee MK, Jung JS, Choi JI, Jang JA, Kang KS, Im YB and Kang SK: MicroRNA 486 is a potentially novel target for the treatment of spinal cord injury. Brain. 135:1237–1252. 2012. View Article : Google Scholar : PubMed/NCBI

73 

Hu Z, Yu D, Almeida-Suhett C, Tu K, Marini AM, Eiden L, Braga MF, Zhu J and Li Z: Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury. PLoS One. 7:e393572012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Ji B, Cheng B, Chen J and Bai B: Neuroprotection of microRNA in neurological disorders (Review). Biomed Rep 2: 611-619, 2014.
APA
Wang, C., Ji, B., Cheng, B., Chen, J., & Bai, B. (2014). Neuroprotection of microRNA in neurological disorders (Review). Biomedical Reports, 2, 611-619. https://doi.org/10.3892/br.2014.297
MLA
Wang, C., Ji, B., Cheng, B., Chen, J., Bai, B."Neuroprotection of microRNA in neurological disorders (Review)". Biomedical Reports 2.5 (2014): 611-619.
Chicago
Wang, C., Ji, B., Cheng, B., Chen, J., Bai, B."Neuroprotection of microRNA in neurological disorders (Review)". Biomedical Reports 2, no. 5 (2014): 611-619. https://doi.org/10.3892/br.2014.297
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Ji B, Cheng B, Chen J and Bai B: Neuroprotection of microRNA in neurological disorders (Review). Biomed Rep 2: 611-619, 2014.
APA
Wang, C., Ji, B., Cheng, B., Chen, J., & Bai, B. (2014). Neuroprotection of microRNA in neurological disorders (Review). Biomedical Reports, 2, 611-619. https://doi.org/10.3892/br.2014.297
MLA
Wang, C., Ji, B., Cheng, B., Chen, J., Bai, B."Neuroprotection of microRNA in neurological disorders (Review)". Biomedical Reports 2.5 (2014): 611-619.
Chicago
Wang, C., Ji, B., Cheng, B., Chen, J., Bai, B."Neuroprotection of microRNA in neurological disorders (Review)". Biomedical Reports 2, no. 5 (2014): 611-619. https://doi.org/10.3892/br.2014.297
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