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Article

Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation

  • Authors:
    • Kenroh Sasaki
    • Syuko Chiba
    • Fumihiko Yoshizaki
  • View Affiliations / Copyright

    Affiliations: Tohoku Pharmaceutical University, Sendai, Miyagi 981‑8558, Japan
  • Pages: 628-632
    |
    Published online on: June 25, 2014
       https://doi.org/10.3892/br.2014.304
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Abstract

The aim of the present study was to identify the inhibitory activity of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation. Antioxidant activity was evaluated using 1,1‑diphenyl‑2‑picrylhydrazyl radical‑scavenging activity. The production of 3‑deoxyglucosone (3‑DG) and advanced glycation end products (AGEs) by glycation reactions were determined by high‑performance liquid chromatography and fluorescence, respectively. Certain flavonoids, stilbenes and caffeic acid oligomers prevented AGE production and the IC50 values of the compounds were compared. These examined compounds are assumed to suppress AGE generation by inhibiting the increase in 3‑DG production through a specific unknown mechanism in the early phase of the Maillard reaction, by inhibiting the generation of active oxygen in the later phase and by suppressing the progression of the reaction. Regular, daily consumption of these compounds in the form of a food or extract is expected to aid in the prevention or inhibition of non‑enzymatic amino acid glycation in the living body, which is possibly associated with aging, diabetic complications, arteriosclerotic diseases and Alzheimer's disease, and they may also be effective agents in cosmetics promoting anti‑aging.
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1 

Barlovic DP, Soro-Paavonen A and Jandeleit-Dahm KA: RAGE biology, atherosclerosis and diabetes. Clin Sci (Lond). 121:43–55. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Vitek MP, Bhattacharya K, Glendening JM, Stopa E, Vlassara H, Bucala R, Manogue K and Cerami A: Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci USA. 91:4766–4770. 1994. View Article : Google Scholar : PubMed/NCBI

3 

Sasaki N, Toki S, Chowei H, Saito T, Nakano N, Hayashi Y, Takeuchi M and Makita Z: Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer’s disease. Brain Res. 888:256–262. 2001.PubMed/NCBI

4 

Sasaki N, Takeuchi M, Chowei H, Kikuchi S, Hayashi Y, Nakano N, Ikeda H, Yamagishi S, Kitamoto T, Saito T and Makita Z: Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques. Neurosci Lett. 326:117–120. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Kikuchi S, Shinpo K, Ogata A, Tsuji S, Takeuchi M, Makita Z and Tashiro K: Detection of N epsilon-(carboxymethyl)lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord. Amytroph Lateral Scler Other Motor Neuron Disord. 3:63–68. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Abe R, Shimizu T, Sugawara H, Watanabe H, Nakamura H, Choei H, Sasaki N, Yamagishi S, Takeuchi M and Shimizu H: Regulation of human melanoma growth and metastasis by AGE-AGE receptor interactions. J Invest Dermatol. 122:461–467. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Dyer DG, Blackledge JA, Thorpe SR and Baynes JW: Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo. J Biol Chem. 266:11654–11660. 1991.PubMed/NCBI

8 

Kato H, van Chyuyen N, Shinoda T, Sekiya F and Hayase F: Metabolism of 3-deoxyglucosone, an intermediate compound in the Maillard reaction, administered orally or intravenously to rats. Biochem Biophys Acta. 1035:71–76. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Rice-Evans C, Spencer JP, Schroeter H and Rechner AR: Bioavailability of flavonoids and potential bioactive forms in vivo. Drug Metabol Drug Interact. 17:291–310. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Kang GJ, Han SC, Yi EJ, Kang HK and Yoo ES: The inhibitory effect of premature Citrus unshiu extract on atopic dermatitis in vitro and in vivo. Toxicol Res. 27:173–180. 2011.

11 

Baek SH, Kim SM, Nam D, Lee JH and Ahn KS, Choi SH, Kim SH, Shim BS, Chang IM and Ahn KS: Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9. Pharm Biol. 50:1210–1218. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Manthey JA and Guthrie N: Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J Agric Food Chem. 50:5837–5843. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Yamamoto H, Sakakibara J, Nagatsu A and Sekiya K: Inhibitors of arachidonate lipoxygenase from defatted perilla seed. J Agric Food Chem. 46:862–865. 1998. View Article : Google Scholar

14 

Nakamura Y, Ohto Y, Murakami A and Ohigashi H: Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo. Jpn J Cancer Res. 89:361–370. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Sasaki K and Yoshizaki F: Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit. Biol Pharm Bull. 25:806–808. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Kobayashi K, Ishihara T, Khono E, Miyase T and Yoshizaki F: Constituents of stem bark of Callistemon rigidus showing inhibitory effects on mouse alpha-amylase activity. Biol Pharm Bull. 29:1275–1277. 2006.PubMed/NCBI

17 

Murata T, Sasaki K, Sato K, Yoshizaki F, Yamada H, Mutoh H, Umehara K, Miyase T, Warashina T, Aoshima H, et al: Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum. J Nat Prod. 72:1379–1384. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Lee SK, Mbwambo ZH, Chung H, Luyengi L, Gamez EJ, Mehta RG, Kinghorn AD and Pezzuto JM: Evaluation of the antioxidant potential of natural products. Comb Chem High Throughput Screen. 1:35–46. 1998.PubMed/NCBI

19 

Valencia JV, Weldon SC, Quinn D, Kiers GH, DeGroot J, TeKoppele JM and Hughes TE: Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics. Anal Biochem. 324:68–78. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Yamada H, Miyata S, Igaki N, Yatabe H, Miyauchi Y, Ohara T, Sakai M, Shoda H, Oimomi M and Kasuga M: Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction. J Biol Chem. 269:20275–20280. 1994.PubMed/NCBI

21 

Edelstein D and Brownlee M: Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine. Diabetes. 41:26–29. 1992. View Article : Google Scholar : PubMed/NCBI

22 

Sady C, Khosrof S and Nagaraj R: Advanced Maillard reaction and crosslinking of corneal collagen in diabetes. Biochem Biophys Res Commun. 214:793–797. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Ahmed MU, Thorpe SR and Baynes JW: Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein. J Biol Chem. 261:4889–4894. 1986.PubMed/NCBI

24 

Reddy S, Bichler J, Wells-Knecht KJ, Thorpe SR and Baynes JW: N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins. Biochemistry. 34:10872–10878. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Thornalley PJ, Langborg A and Minhas HS: Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J. 344:109–116. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Wei J, Jin F, Wu Q, Jiang Y, Gao D and Liu H: Molecular interaction study of flavonoid derivative 3d with human serum albumin using multispectroscopic and molecular modeling approach. Talanta. 126:116–121. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Richard T, Lefeuvre D, Descendit A, Quideau S and Monti JP: Recognition characters in peptide-polyphenol complex formation. Biochim Biophys Acta. 1760:951–958. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sasaki K, Chiba S and Yoshizaki F: Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation. Biomed Rep 2: 628-632, 2014.
APA
Sasaki, K., Chiba, S., & Yoshizaki, F. (2014). Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation. Biomedical Reports, 2, 628-632. https://doi.org/10.3892/br.2014.304
MLA
Sasaki, K., Chiba, S., Yoshizaki, F."Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation". Biomedical Reports 2.5 (2014): 628-632.
Chicago
Sasaki, K., Chiba, S., Yoshizaki, F."Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation". Biomedical Reports 2, no. 5 (2014): 628-632. https://doi.org/10.3892/br.2014.304
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki K, Chiba S and Yoshizaki F: Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation. Biomed Rep 2: 628-632, 2014.
APA
Sasaki, K., Chiba, S., & Yoshizaki, F. (2014). Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation. Biomedical Reports, 2, 628-632. https://doi.org/10.3892/br.2014.304
MLA
Sasaki, K., Chiba, S., Yoshizaki, F."Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation". Biomedical Reports 2.5 (2014): 628-632.
Chicago
Sasaki, K., Chiba, S., Yoshizaki, F."Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation". Biomedical Reports 2, no. 5 (2014): 628-632. https://doi.org/10.3892/br.2014.304
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