Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-October 2014 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2014 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2

  • Authors:
    • Xulong Lang
    • Zhonghai Wan
    • Zhaoyang Bu
    • Xiuran Wang
    • Xiaoxu Wang
    • Lingwei Zhu
    • Jiayu Wan
    • Yang Sun
    • Xinglong Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China, School of Life Science, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China
  • Pages: 709-712
    |
    Published online on: June 30, 2014
       https://doi.org/10.3892/br.2014.307
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Streptococcus suis (S. suis) type 2 is an extremely important Gram‑positive bacterial pathogen that can cause human or swine endocarditis, meningitis, bronchopneumonia, arthritis and sepsis. Catabolite control protein A (CcpA) is a major transcriptional regulator in S. suis type 2 that functions in catabolite control, specifically during growth on glucose or galactose. The regulation of central metabolism can affect the virulence of bacteria. In the present study, a metabolomics approach was used along with principal components analysis (PCA) and partial least-squares‑discriminant analysis (PLS‑DA) models and 37 metabolites were found that differed substantially between native S. suis and a mutant lacking CcpA. These results showed that CcpA is an important protein in S. suis type 2 for studying bacterial protein function.
View Figures

Figure 1

View References

1 

Willenborg J, Fulde M, de Greeff A, Rohde M, Smith HE, Valentin-Weigand P and Goethe R: Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis. Microbiology. 157:1823–1833. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zhang J, Zhu J, Ren H, Zhu S, Zhao P, Zhang F, Lv H, Hu D, Hao L, Geng M, et al: Rapid visual detection of highly pathogenic Streptococcus suis serotype 2 isolates by use of loop-mediated isothermal amplification. J Clin Microbiol. 51:3250–3256. 2013.PubMed/NCBI

3 

Görke B and Stülke J: Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol. 6:613–624. 2008.PubMed/NCBI

4 

Deutscher J: The mechanisms of carbon catabolite repression in bacteria. Curr Opin Microbiol. 11:87–93. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Warner JB and Lolkema JS: CcpA-dependent carbon catabolite repression in bacteria. Microbiol Mol Biol Rev. 67:475–490. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Abranches J, Nascimento MM, Zeng L, Browngardt CM, Wen ZT, Rivera MF and Burne RA: CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans. J Bacteriol. 190:2340–2349. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Zheng L, Chen Z, Itzek A, Ashby M and Kreth J: Catabolite control protein A controls hydrogen peroxide production and cell death in Streptococcus sanguinis. J Bacteriol. 193:516–526. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Carvalho SM, Kloosterman TG, Kuipers OP and Neves AR: CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae. PLoS One. 6:e267072011. View Article : Google Scholar : PubMed/NCBI

9 

Leiba J, Hartmann T, Cluzel ME, Cohen-Gonsaud M, Delolme F, Bischoff M and Molle V: A novel mode of regulation of the Staphylococcus aureus catabolite control protein A (CcpA) mediated by Stk1 protein phosphorylation. J Biol Chem. 287:43607–43619. 2012.PubMed/NCBI

10 

Wang Y, Dang Y, Wang X, Lu H, Wang X, Lang X, Li X, Feng S, Zhang F and Ren L: Comparative proteomic analyses of Streptococcus suis serotype 2 cell wall-associated proteins. Curr Microbiol. 62:578–588. 2011.PubMed/NCBI

11 

Teng Q, Huang WL, Collette TW, Ekman DR and Tan C: A direct cell quenching method for cell-culture based metabolomics. Metabolomics. 5:199–208. 2009. View Article : Google Scholar

12 

Chen F, Xue J, Zhou L, Wu S and Chen Z: Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method. Anal Bioanal Chem. 401:1899–1904. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Carrola J, Rocha CM, Barros AS, Gil AM, Goodfellow BJ, Carreira IM, Bernardo J, Gomes A, Sousa V, Carvalho L and Duarte IF: Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine. J Proteome Res. 10:221–230. 2011. View Article : Google Scholar

14 

Berthelot-Hérault F, Gottschalk M, Labbé A, Cariolet R and Kobisch M: Experimental airborne transmission of Streptococcus suis capsular type 2 in pigs. Vet Microbiol. 82:69–80. 2001.

15 

Jiang H, Fan HJ and Lu CP: Identification and distribution of putative virulent genes in strains of Streptococcus suis serotype 2. Vet Microbiol. 133:309–316. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Iyer R, Baliga NS and Camilli A: Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae. J Bacteriol. 187:8340–8349. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Tang Y, Wu W, Zhang X, Lu Z, Chen J and Fang W: Catabolite control protein A of Streptococcus suis type 2 contributes to sugar metabolism and virulence. J Microbiol. 50:994–1002. 2012.

18 

Seidl K, Stucki M, Ruegg M, Goerke C, Wolz C, Harris L, Berger-Bächi B and Bischoff M: Staphylococcus aureus CcpA affects virulence determinant production and antibiotic resistance. Antimicrob Agents Chemother. 50:1183–1194. 2006. View Article : Google Scholar

19 

Kaufman GE and Yother J: CcpA-dependent and -independent control of beta-galactosidase expression in Streptococcus pneumoniae occurs via regulation of an upstream phosphotransferase system-encoding operon. J Bacteriol. 189:5183–5192. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Zhang A, Chen B, Yuan Z, Li R, Liu C, Zhou H, Chen H and Jin M: HP0197 contributes to CPS synthesis and the virulence of Streptococcus suis via CcpA. PLoS One. 7:e509872012. View Article : Google Scholar : PubMed/NCBI

21 

Li J, Huang C, Zheng D, Wang Y and Yuan Z: CcpA-mediated enhancement of sugar and amino acid metabolism in Lysinibacillus sphaericus by NMR-based metabolomics. J Proteome Res. 11:4654–4661. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Ludwig H, Meinken C, Matin A and Stülke J: Insufficient expression of the ilv-lew operon encoding enzymes of branched-chain amino acid biosynthesis limits growth of a Bacillus subtilis ccpA mutant. J Bacteriol. 184:5174–5178. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Fujita Y: Carbon catabolite control of the metabolic network in Bacillus subtilis. Biosci Biotechnol Biochem. 73:245–259. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Basavanna S, Chimalapati S, Maqbool A, Rubbo B, Yuste J, Wilson RJ, Hosie A, Ogunniyi AD, Paton JC, Thomas G and Brown JS: The effects of methionine acquisition and synthesis on Streptococcus pneumoniae growth and virulence. PLoS One. 8:e496382013. View Article : Google Scholar : PubMed/NCBI

25 

Arya T, Kishor C, Saddanapu V, Reddi R and Addlagatta A: Discovery of a new genetic variant of methionine aminopeptidase from Streptococci with possible post-translational modifications: biochemical and structural characterization. PLoS One. 8:e752072013. View Article : Google Scholar : PubMed/NCBI

26 

Hendriksen WT, Kloosterman TG, Bootsma HJ, Estevão S, de Groot R, Kuipers OP and Hermans PW: Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae. Infect Immun. 76:1230–1238. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Chen PM, Chen YY, Yu SL, Sher S, Lai CH and Chia JS: Role of GlnR in acid-mediated repression of genes encoding proteins involved in glutamine and glutamate metabolism in Streptococcus mutans. Appl Environ Microbiol. 76:2478–2486. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Kloosterman TG, Hendriksen WT, Bijlsma JJ, Bootsma HJ, van Hijum SA, Kok J, Hermans PW and Kuipers OP: Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae. J Biol Chem. 281:25097–25109. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lang X, Wan Z, Bu Z, Wang X, Wang X, Zhu L, Wan J, Sun Y and Wang X: Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2. Biomed Rep 2: 709-712, 2014.
APA
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L. ... Wang, X. (2014). Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2. Biomedical Reports, 2, 709-712. https://doi.org/10.3892/br.2014.307
MLA
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2". Biomedical Reports 2.5 (2014): 709-712.
Chicago
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2". Biomedical Reports 2, no. 5 (2014): 709-712. https://doi.org/10.3892/br.2014.307
Copy and paste a formatted citation
x
Spandidos Publications style
Lang X, Wan Z, Bu Z, Wang X, Wang X, Zhu L, Wan J, Sun Y and Wang X: Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2. Biomed Rep 2: 709-712, 2014.
APA
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L. ... Wang, X. (2014). Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2. Biomedical Reports, 2, 709-712. https://doi.org/10.3892/br.2014.307
MLA
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2". Biomedical Reports 2.5 (2014): 709-712.
Chicago
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2". Biomedical Reports 2, no. 5 (2014): 709-712. https://doi.org/10.3892/br.2014.307
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team