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Article

Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia

  • Authors:
    • Dongjun Dai
    • Yunliang Wang
    • Jiaojiao Yuan
    • Xingyu Zhou
    • Danjie Jiang
    • Jinfeng Li
    • Yuzheng Zhang
    • Honglei Yin
    • Shiwei Duan
  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Department of Neurology, The 148 Central Hospital of People's Liberation Army, Zibo, Shandong 255300, P.R. China
  • Pages: 729-736
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    Published online on: June 30, 2014
       https://doi.org/10.3892/br.2014.308
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Abstract

Schizophrenia (SCZ) is a severe complex psychiatric disorder that generates problems for the associated family and society and causes disability with regards to work for patients. The aim of the present study was to assess the contribution of 10 genetic polymorphisms to SCZ susceptibility. Meta‑analyses were conducted using the data without a limitation for time or language. A total of 27 studies with 7 genes and 10 polymorphisms were selected for the meta‑analyses. Two polymorphisms were found to be significantly associated with SCZ. SNAP25 rs3746544 was shown to increase the SCZ risk by 18% [P=0.01; odds ratio (OR), 1.18; 95% confidence interval (CI), 1.05‑1.34] and GRIK3 rs6691840 was found to increase the risk by 30% (P=0.008; OR, 1.30; 95% CI, 1.07‑1.58). Significant results were found under the dominant (P=0.001; OR, 1.36; 95% CI, 1.13‑1.65) and additive (P=0.02; OR, 1.45; 95% CI, 1.06‑1.98) model for the SNAP25 rs3746544 polymorphism and under the additive model for the GRIK3 rs6691840 polymorphism (P=0.03; OR, 1.73; 95% CI, 1.04‑2.85). There were no significant results observed for the other eight polymorphisms, which were CCKAR rs1800857, CHRNA7 rs904952, CHRNA7 rs6494223, CHRNA7 rs2337506, DBH Ins>Del, FEZ1 rs559668, FEZ1 rs597570 and GCLM rs2301022. In conclusion, the present meta‑analyses indicated that the SNAP25 rs3746544 and GRIK3 rs6691840 polymorphisms were risk factors of SCZ, which may provide valuable information for the clinical diagnosis of SCZ.
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Copy and paste a formatted citation
Spandidos Publications style
Dai D, Wang Y, Yuan J, Zhou X, Jiang D, Li J, Zhang Y, Yin H and Duan S: Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia. Biomed Rep 2: 729-736, 2014.
APA
Dai, D., Wang, Y., Yuan, J., Zhou, X., Jiang, D., Li, J. ... Duan, S. (2014). Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia. Biomedical Reports, 2, 729-736. https://doi.org/10.3892/br.2014.308
MLA
Dai, D., Wang, Y., Yuan, J., Zhou, X., Jiang, D., Li, J., Zhang, Y., Yin, H., Duan, S."Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia". Biomedical Reports 2.5 (2014): 729-736.
Chicago
Dai, D., Wang, Y., Yuan, J., Zhou, X., Jiang, D., Li, J., Zhang, Y., Yin, H., Duan, S."Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia". Biomedical Reports 2, no. 5 (2014): 729-736. https://doi.org/10.3892/br.2014.308
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Spandidos Publications style
Dai D, Wang Y, Yuan J, Zhou X, Jiang D, Li J, Zhang Y, Yin H and Duan S: Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia. Biomed Rep 2: 729-736, 2014.
APA
Dai, D., Wang, Y., Yuan, J., Zhou, X., Jiang, D., Li, J. ... Duan, S. (2014). Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia. Biomedical Reports, 2, 729-736. https://doi.org/10.3892/br.2014.308
MLA
Dai, D., Wang, Y., Yuan, J., Zhou, X., Jiang, D., Li, J., Zhang, Y., Yin, H., Duan, S."Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia". Biomedical Reports 2.5 (2014): 729-736.
Chicago
Dai, D., Wang, Y., Yuan, J., Zhou, X., Jiang, D., Li, J., Zhang, Y., Yin, H., Duan, S."Meta‑analyses of 10 polymorphisms associated with the risk of schizophrenia". Biomedical Reports 2, no. 5 (2014): 729-736. https://doi.org/10.3892/br.2014.308
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