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Article

Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease

  • Authors:
    • Dongjun Dai
    • Yunliang Wang
    • Xingyu Zhou
    • Jianmin Tao
    • Danjie Jiang
    • Hanlin Zhou
    • Yi Jiang
    • Guanghui Pan
    • Ping Ru
    • Huihui Ji
    • Jinfeng Li
    • Yuzheng Zhang
    • Honglei Yin
    • Mingqing Xu
    • Shiwei Duan
  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Department of Neurology, The 148 Central Hospital of People's Liberation Army, Zibo, Shandong 255300, P.R. China, Bio‑X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Xuhui, Shanghai 200240, P.R. China
  • Pages: 886-892
    |
    Published online on: July 31, 2014
       https://doi.org/10.3892/br.2014.324
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Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects ~2% of the global population aged ≥65 years. Grb10‑interacting GYF protein‑2 (GIGYF2) can influence the development of PD through the regulation of insulin‑like growth factor‑1. The aim of the present meta‑analysis study was to establish the contribution of GIGYF2 polymorphisms to PD. The study was conducted based on nine eligible studies consisting of 7,246 PD patients and 7,544 healthy controls. The results indicated that the GIGYF2 C.3630A>G polymorphism increased the risk of PD by 37% [P=0.008; odds ratio (OR), 1.37; 95% confidence interval (CI), 1.08‑1.73] and that the GIGYF2 C.167G>A polymorphism was significantly associated with PD (P=0.003; OR, 3.67; 95% CI, 1.56‑8.68). The meta‑analyses of the other five GIGYF2 polymorphisms (C.1378C>A, C.1554G>A, C.2940A>G, C.1370C>A and C.3651G>A) did not reveal any significant associations. The present meta‑analyses of the GIGYF2 genetic polymorphisms may provide a comprehensive overview of this PD candidate gene for future studies.
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Copy and paste a formatted citation
Spandidos Publications style
Dai D, Wang Y, Zhou X, Tao J, Jiang D, Zhou H, Jiang Y, Pan G, Ru P, Ji H, Ji H, et al: Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease. Biomed Rep 2: 886-892, 2014.
APA
Dai, D., Wang, Y., Zhou, X., Tao, J., Jiang, D., Zhou, H. ... Duan, S. (2014). Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease. Biomedical Reports, 2, 886-892. https://doi.org/10.3892/br.2014.324
MLA
Dai, D., Wang, Y., Zhou, X., Tao, J., Jiang, D., Zhou, H., Jiang, Y., Pan, G., Ru, P., Ji, H., Li, J., Zhang, Y., Yin, H., Xu, M., Duan, S."Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease". Biomedical Reports 2.6 (2014): 886-892.
Chicago
Dai, D., Wang, Y., Zhou, X., Tao, J., Jiang, D., Zhou, H., Jiang, Y., Pan, G., Ru, P., Ji, H., Li, J., Zhang, Y., Yin, H., Xu, M., Duan, S."Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease". Biomedical Reports 2, no. 6 (2014): 886-892. https://doi.org/10.3892/br.2014.324
Copy and paste a formatted citation
x
Spandidos Publications style
Dai D, Wang Y, Zhou X, Tao J, Jiang D, Zhou H, Jiang Y, Pan G, Ru P, Ji H, Ji H, et al: Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease. Biomed Rep 2: 886-892, 2014.
APA
Dai, D., Wang, Y., Zhou, X., Tao, J., Jiang, D., Zhou, H. ... Duan, S. (2014). Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease. Biomedical Reports, 2, 886-892. https://doi.org/10.3892/br.2014.324
MLA
Dai, D., Wang, Y., Zhou, X., Tao, J., Jiang, D., Zhou, H., Jiang, Y., Pan, G., Ru, P., Ji, H., Li, J., Zhang, Y., Yin, H., Xu, M., Duan, S."Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease". Biomedical Reports 2.6 (2014): 886-892.
Chicago
Dai, D., Wang, Y., Zhou, X., Tao, J., Jiang, D., Zhou, H., Jiang, Y., Pan, G., Ru, P., Ji, H., Li, J., Zhang, Y., Yin, H., Xu, M., Duan, S."Meta‑analyses of seven GIGYF2 polymorphisms with Parkinson's disease". Biomedical Reports 2, no. 6 (2014): 886-892. https://doi.org/10.3892/br.2014.324
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