Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
November-December 2014 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2014 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis

  • Authors:
    • Peng‑Cheng Liu
    • Yun‑Ji Yang
    • Run Liu
    • Chang‑Jia Huang
    • He‑Xi Shu
    • Jin‑Peng Gong
    • Quan‑Chi Chen
    • Yong Yang
    • Ming Cai
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China
  • Pages: 849-854
    |
    Published online on: August 4, 2014
       https://doi.org/10.3892/br.2014.326
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have shown conflicting results between the association of leptin receptor (LEPR) genetic polymorphisms and cancer risk. The frequent LEPR Lys656Asn or Ser343Ser genetic polymorphism has been demonstrated to be functional and may promote genetic susceptibility to cancers. However, the association between the LEPR Lys656Asn or Ser343Ser genetic polymorphism and cancer risk remains to be determined. To improve the understanding of the LEPR Lys656Asn or Ser343Ser genetic polymorphism role in global cancer, a comprehensive meta‑analysis was conducted that comprised 2,480 cases and 3,162 controls. The LEPR Lys656Asn or Ser343Ser genetic polymorphism did not significantly affect the cancer risk. In the stratified analysis, there was no significant association of the LEPR Lys656Asn or Ser343Ser variants with any type of cancer under any model. In addition, significantly increased risks were found in the Asian population in heterozygous codominant [odds ratio (OR), 1.24 (1.01‑1.53)] and dominant [OR, 1.24 (1.02‑1.50)] genetic models. A significantly increased susceptibility to cancer was not found when stratified by study design. There were no significant differences found in genotype method and sample size in cases among the genotypes. These findings indicated a lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility, however, these polymorphisms may increase the cancer susceptibility among the Asian population, particularly in the dominant genetic model. The single‑nucleotide polymorphism is also suggested to function as a dominant mutation, which requires verification or association with functional studies.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar

2 

Wright ME, Peters U, Gunter MJ, et al: Association of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk. Cancer Res. 69:1429–1438. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Cheung WY and Liu G: Genetic variations in esophageal cancer risk and prognosis. Gastroenterol Clin North Am. 38:75–91. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Friedman JM and Halaas JL: Leptin and the regulation of body weight in mammals. Nature. 395:763–770. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Unger RH, Zhou YT and Orci L: Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci USA. 96:2327–2332. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Lakka HM, Oksanen L, Tuomainen TP, Kontula K and Salonen JT: The common pentanucleotide polymorphism of the 3′-untranslated region of the leptin receptor gene is associated with serum insulin levels and the risk of type 2 diabetes in non-diabetic men: a prospective case-control study. J Intern Med. 248:77–83. 2000.

7 

Lönnqvist F, Arner P, Nordfors L and Schalling M: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med. 1:950–953. 1995.PubMed/NCBI

8 

Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D and Mantzoros CS: The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab. 86:4434–4439. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Snoussi K, Strosberg AD, Bouaouina N, Ben Ahmed S, Helal AN and Chouchane L: Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer. 6:382006. View Article : Google Scholar : PubMed/NCBI

10 

Liu CL, Chang YC, Cheng SP, et al: The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer. Oncology. 72:75–81. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Han CZ, Du LL, Jing JX, et al: Associations among lipids, leptin, and leptin receptor gene Gin223Arg polymorphisms and breast cancer in China. Biol Trace Elem Res. 126:38–48. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Ribeiro R, Vasconcelos A, Costa S, et al: Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease. Prostate. 59:268–274. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Ribeiro R, Araújo AP, Coelho A, et al: A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer. Eur J Cancer. 42:1188–1193. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Chia VM, Newcomb PA, Lampe JW, et al: Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 16:2697–2703. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Loffreda S, Yang SQ, Lin HZ, et al: Leptin regulates proinflammatory immune responses. FASEB J. 12:57–65. 1998.PubMed/NCBI

16 

Russo VC, Metaxas S, Kobayashi K, Harris M and Werther GA: Antiapoptotic effects of leptin in human neuroblastoma cells. Endocrinology. 145:4103–4112. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Woo HY, Park H, Ki CS, Park YL and Bae WG: Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea. Cancer Lett. 237:137–142. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Doecke JD, Zhao ZZ, Stark MS, et al; Australian Cancer Study. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiol Biomarkers Prev. 17:1007–1012. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Teras LR, Goodman M, Patel AV, et al: No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 18:2553–2557. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Li Y, Geng J, Wang Y, et al: The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients. J Cancer Res Clin Oncol. 138:311–316. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Kim EY, Chin HM, Park SM, et al: Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea. J Korean Surg Soc. 83:7–13. 2012. View Article : Google Scholar : PubMed/NCBI

22 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

23 

Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI

24 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Bianchini F, Kaaks R and Vainio H: Overweight, obesity, and cancer risk. Lancet Oncol. 3:565–574. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Calle EE, Rodriguez C, Walker-Thurmond K and Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 348:1625–1638. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu PC, Yang YJ, Liu R, Huang CJ, Shu HX, Gong JP, Chen QC, Yang Y and Cai M: Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis. Biomed Rep 2: 849-854, 2014.
APA
Liu, P., Yang, Y., Liu, R., Huang, C., Shu, H., Gong, J. ... Cai, M. (2014). Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis. Biomedical Reports, 2, 849-854. https://doi.org/10.3892/br.2014.326
MLA
Liu, P., Yang, Y., Liu, R., Huang, C., Shu, H., Gong, J., Chen, Q., Yang, Y., Cai, M."Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis". Biomedical Reports 2.6 (2014): 849-854.
Chicago
Liu, P., Yang, Y., Liu, R., Huang, C., Shu, H., Gong, J., Chen, Q., Yang, Y., Cai, M."Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis". Biomedical Reports 2, no. 6 (2014): 849-854. https://doi.org/10.3892/br.2014.326
Copy and paste a formatted citation
x
Spandidos Publications style
Liu PC, Yang YJ, Liu R, Huang CJ, Shu HX, Gong JP, Chen QC, Yang Y and Cai M: Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis. Biomed Rep 2: 849-854, 2014.
APA
Liu, P., Yang, Y., Liu, R., Huang, C., Shu, H., Gong, J. ... Cai, M. (2014). Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis. Biomedical Reports, 2, 849-854. https://doi.org/10.3892/br.2014.326
MLA
Liu, P., Yang, Y., Liu, R., Huang, C., Shu, H., Gong, J., Chen, Q., Yang, Y., Cai, M."Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis". Biomedical Reports 2.6 (2014): 849-854.
Chicago
Liu, P., Yang, Y., Liu, R., Huang, C., Shu, H., Gong, J., Chen, Q., Yang, Y., Cai, M."Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta‑analysis". Biomedical Reports 2, no. 6 (2014): 849-854. https://doi.org/10.3892/br.2014.326
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team