Expression and significance of transient receptor potential cation channel V5 in articular cartilage cells under exercise loads

Zhou,Xiaonan; Wang,Wei; Miao,Jianing; Bai,Lunhao

doi:10.3892/br.2014.333

November-December 2014 Volume 2 Issue 6

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November-December 2014 Volume 2 Issue 6

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Article

Expression and significance of transient receptor potential cation channel V5 in articular cartilage cells under exercise loads

Authors:
- Xiaonan Zhou
- Wei Wang
- Jianing Miao
- Lunhao Bai
View Affiliations / Copyright

Affiliations: Department of Orthopaedics, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, P.R. China, Research Center, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, P.R. China
Pages: 813-817
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Published online on: August 8, 2014

https://doi.org/10.3892/br.2014.333
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Abstract

The expression of transient receptor potential cation channel V5 (TRPV5) in articular cartilage cells under normal and exercise loading conditions was measured, and the clinical significance, in order to define its role in the formation of articular cartilage tissues was analyzed. In normal and osteoarthritis (OA) Sprague Dawley rats the severity of injury was observed, TRPV5 expression was measured by immunohistochemistry following exercise loading, and its association with clinical pathological characteristics (including articular lesions) was analyzed. The results of the immunohistochemical assay showed that the percentage of positive expression areas in the normal articular cartilage and loading articular cartilage groups was 34.3±5.8 and 18.1±4.9%, respectively. In the OA articular cartilage and OA loading articular cartilage groups, the positive expression areas were 13.17±4.2 and 6.4±2.7%, respectively. There was a statistically significant difference in TRPV5 expression levels between the normal articular cartilage and loading articular cartilage groups, and between the OA articular cartilage and OA loading articular cartilage groups (P<0.001). TRPV5 is expressed in all bone cartilage tissues and its expression level depends on the load of the bone and joint. Therefore, this indicates that TRPV5 may play a role in the formation and development processes of cartilage tissues.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression and significance of transient receptor potential cation channel V5 in articular cartilage cells under exercise loads

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