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Article

Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats

  • Authors:
    • Ying Jiang
    • Shigang Shan
    • Tieer Gan
    • Xiaoyun Zhang
    • Xianghong Lu
    • Hu Hu
    • Yihua Wu
    • Jianzhong Sheng
    • Jun Yang
  • View Affiliations / Copyright

    Affiliations: The First Affiliated Hospital, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Pharmacy, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China
  • Pages: 893-897
    |
    Published online on: August 19, 2014
       https://doi.org/10.3892/br.2014.349
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Abstract

DNA‑damaging agents have been reported to be associated with cardiovascular complications, however, the underlying mechanisms remain to be clarified. In the present study, the possible vascular effects of cisplatin was assessed by measuring its effects on the contractile function of thoracic aortic rings dissected from Sprague‑Dawley (SD) rats. Contraction of the aortic ring was induced by 60 mM KCl or 10‑6 M phenylephrine (PE) in an ex vivo perfusion system. Cisplatin (200 µM) counteracted KCl‑ and PE‑induced contraction by 57.6 and 91.8%, respectively, in endothelium‑intact aortic rings. Similar results were obtained in endothelium‑denuded aortas. Electromicroscopy analysis revealed severe damage to blood vessel walls in vivo by cisplatin. In addition, cisplatin significantly inhibited adenosine triphosphate (ATP)‑induced intracellular Ca2+ concentration ([Ca2+]i) increases in human umbilical vein endothelial cells (HUVECs). These results suggested that the DNA‑damaging agent cisplatin can affect the contractile function of thoracic aortas. In addition, in accordance with its DNA‑damaging properties, the cardiovascular toxicity of cisplatin may be the result of its direct cytotoxicity.
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1 

Williams GM and Weisburger JH: Chemical carcinogenesis. Casarett and Doull’s Toxicology: The Basic Science of Poisons. Amdur MO, Doull J and Klaassen CD: 4th edition. Pergamon Press; New York, NY: pp. 127–132. 1991

2 

Abu-Surrah AS and Kettunen M: Platinum group antitumor chemistry: design and development of new anticancer drugs complementary to cisplatin. Curr Med Chem. 13:1337–1357. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Fuertes MA, Castilla J, Alonso C and Perez JM: Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Curr Med Chem. 10:257–266. 2003. View Article : Google Scholar

4 

Shinohara K, Bando T, Sasaki S, Sakakibara Y, Minoshima M and Sugiyama H: Antitumor activity of sequence-specific alkylating agents: pyrolle-imidazole CBI conjugates with indole linker. Cancer Sci. 97:219–225. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Doll DC, List AF, Greco FA, Hainsworth JD, Hande KR and Johnson DH: Acute vascular ischemic events after cisplatin-based combination chemotherapy for germ-cell tumors of the testis. Ann Intern Med. 105:48–51. 1986. View Article : Google Scholar : PubMed/NCBI

6 

Huddart RA, Norman A, Shahidi M, et al: Cardiovascular disease as a long-term complication of treatment for testicular cancer. J Clin Oncol. 21:1513–1523. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Vaughn DJ, Palmer SC, Carver JR, Jacobs LA and Mohler ER: Cardiovascular risk in long-term survivors of testicular cancer. Cancer. 112:1949–1953. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Nuver J, Smit AJ, van der Meer J, et al: Acute chemotherapy-induced cardiovascular changes in patients with testicular cancer. J Clin Oncol. 23:9130–9137. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Kirchmair R, Walter DH, Ii M, et al: Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth. Circulation. 111:2662–2670. 2005. View Article : Google Scholar

10 

Kohn S, Fradis M, Ben-David J, Zidan J and Robinson E: Nephrotoxicity of combined treatment with cisplatin and gentamicin in the guinea pig: glomerular injury findings. Ultrastruct Pathol. 26:371–382. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Yu M, Han J, Cui P, et al: Cisplatin up-regulates ICAM-1 expression in endothelial cell via a NF-kappaB dependent pathway. Cancer Sci. 99:391–397. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Aromolaran AS, Zima AV and Blatter LA: Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. Am J Physiol Cell Physiol. 293:C106–C118. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Mellander S: Contribution of small vessel tone to the regulation of blood volume and formation of oedema. Proc R Soc Med. 61:55–61. 1968.PubMed/NCBI

14 

Suga H: Physiological interpretation of negative circumferential tension in vascular walls. Jpn Heart J. 32:473–480. 1991. View Article : Google Scholar : PubMed/NCBI

15 

Nichols WV and O’Rourke MF: McDonald’s Blood Flow in Arteries: Theoretical, Experimental, and Clinical Principles. 5th edition. Hodder Arnold; London: pp. 344–347. 2005

16 

Struijker Boudier HAJ: Vascular growth and hypertension. Textbook of Hypertension. Swales JD: Blackwell Scientific; Oxford: pp. 200–213. 1994

17 

Haugnes HS, Aass N, Fossa SD, et al: Predicted cardiovascular mortality and reported cardiovascular morbidity in testicular cancer survivors. J Cancer Surviv. 2:128–137. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Sagstuen H, Aass N, Fossa SD, et al: Blood pressure and body mass index in long-term survivors of testicular cancer. J Clin Oncol. 23:4980–4990. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Gong Z, Yang J, Yang M, et al: Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. Toxicol Lett. 166:229–236. 2006.

20 

Kamata K and Kojima S: Characteristics of contractile responses of aorta to norepinephrine in db/db mice. Res Commun Mol Pathol Pharmacol. 96:319–328. 1997.PubMed/NCBI

21 

Qian LB, Wang HP, Qiu WL, Huang H, Bruce IC and Xia Q: Interleukin-2 protects against endothelial dysfunction induced by high glucose levels in rats. Vascul Pharmacol. 45:374–382. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Ru XC, Qian LB, Gao Q, Li YF, Bruce IC and Xia Q: Alcohol induces relaxation of rat thoracic aorta and mesenteric arterial bed. Alcohol Alcohol. 43:537–543. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Sheng JZ, Wang D and Braun AP: DAF-FM (4-amino-5-methylamino-2′,7′-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin. J Pharmacol Exp Ther. 315:931–940. 2005.

24 

Luscher TF and Tanner FC: Endothelial regulation of vascular tone and growth. Am J Hypertens. 6:283S–293S. 1993.PubMed/NCBI

25 

Ishioka J, Fujii Y, Kageyama Y, Fukuda H, Higashi Y and Kihara K: Cardiovascular events in survivors of high-dose chemotherapy for germ cell tumors. Int J Urol. 15:642–645. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Fukunaga T, Soejima H, Sugamura K, et al: Acute myocardial infarction induced by cisplatin-based combination chemotherapy for malignant melanoma: a case report. J Cardiol. 47:191–195. 2006.PubMed/NCBI

27 

Oh JH, Baum DD, Pham S, et al: Long-term complications of platinum-based chemotherapy in testicular cancer survivors. Med Oncol. 24:175–181. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Etgen T, Weidenhofer G and Kubin T: Cisplatin-associated occlusion of the internal carotid artery. Onkologie. 32:754–757. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Grenader T, Shavit L, Ospovat I, Gutfeld O and Peretz T: Aortic occlusion in patients treated with cisplatin-based chemotherapy. Mt Sinai J Med. 73:810–812. 2006.PubMed/NCBI

30 

Ghosh N, Chow CM, Korley V and Chisholm R: An unusual case of chronic coronary artery dissection: did cisplatin play a role? Can J Cardiol. 24:795–797. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Dabagh M, Jalali P, Konttinen YT and Sarkomaa P: Distribution of shear stress over smooth muscle cells in deformable arterial wall. Med Biol Eng Comput. 46:649–657. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Oesterling E, Toborek M and Hennig B: Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway. Toxicol Appl Pharmacol. 232:309–316. 2008.

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Shan S, Gan T, Zhang X, Lu X, Hu H, Wu Y, Sheng J and Yang J: Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats. Biomed Rep 2: 893-897, 2014.
APA
Jiang, Y., Shan, S., Gan, T., Zhang, X., Lu, X., Hu, H. ... Yang, J. (2014). Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats. Biomedical Reports, 2, 893-897. https://doi.org/10.3892/br.2014.349
MLA
Jiang, Y., Shan, S., Gan, T., Zhang, X., Lu, X., Hu, H., Wu, Y., Sheng, J., Yang, J."Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats". Biomedical Reports 2.6 (2014): 893-897.
Chicago
Jiang, Y., Shan, S., Gan, T., Zhang, X., Lu, X., Hu, H., Wu, Y., Sheng, J., Yang, J."Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats". Biomedical Reports 2, no. 6 (2014): 893-897. https://doi.org/10.3892/br.2014.349
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Shan S, Gan T, Zhang X, Lu X, Hu H, Wu Y, Sheng J and Yang J: Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats. Biomed Rep 2: 893-897, 2014.
APA
Jiang, Y., Shan, S., Gan, T., Zhang, X., Lu, X., Hu, H. ... Yang, J. (2014). Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats. Biomedical Reports, 2, 893-897. https://doi.org/10.3892/br.2014.349
MLA
Jiang, Y., Shan, S., Gan, T., Zhang, X., Lu, X., Hu, H., Wu, Y., Sheng, J., Yang, J."Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats". Biomedical Reports 2.6 (2014): 893-897.
Chicago
Jiang, Y., Shan, S., Gan, T., Zhang, X., Lu, X., Hu, H., Wu, Y., Sheng, J., Yang, J."Effects of cisplatin on the contractile function of thoracic aorta of Sprague‑Dawley rats". Biomedical Reports 2, no. 6 (2014): 893-897. https://doi.org/10.3892/br.2014.349
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