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Article

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

  • Authors:
    • Cornelia Lerner
    • Silke Wemmert
    • Bernhard Schick
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Saarland University Medical Center, D‑66421 Homburg/Saar, Germany
  • Pages: 835-838
    |
    Published online on: August 19, 2014
       https://doi.org/10.3892/br.2014.350
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Abstract

Juvenile angiofibroma (JA) is a rare fibrovascular tumor affecting, almost exclusively, adolescent males. The finding of frequent β‑catenin‑mutations in JAs emphasized the significance of the Wnt‑signaling pathway in tumor pathogenesis. In the last decade, microRNAs (miRNAs or miRs) have been found to be involved in cancer pathogenesis by post‑transcriptional regulation of gene expression and have not been analyzed in JAs thus far. In the present study, the expression of 4 miRNAs (hsa‑let‑7d, hsa‑miR‑98, hsa‑miR‑125a‑5p and hsa‑miR‑218) was analyzed in 13 JAs and 3 deepithelized inferior nasal turbinates that were used as control tissue. The miRNA expression of hsa‑let‑7d (P=0.158) and hsa‑miR‑98 (P=0.069) was not statistically different between the two tissue types, however, a significant decrease in expression was observed for hsa‑miR‑125a‑5p (P=0.037) and hsa‑miR‑218 (P=0.009) in JAs compared to inferior nasal turbinates. As downregulation of miRNA 218 has been recently shown to result in stabilization and nuclear accumulation of β‑catenin, the present data indicates further evidence for the importance of the Wnt‑signaling pathway in JAs.
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Copy and paste a formatted citation
Spandidos Publications style
Lerner C, Wemmert S and Schick B: Preliminary analysis of different microRNA expression levels in juvenile angiofibromas. Biomed Rep 2: 835-838, 2014.
APA
Lerner, C., Wemmert, S., & Schick, B. (2014). Preliminary analysis of different microRNA expression levels in juvenile angiofibromas. Biomedical Reports, 2, 835-838. https://doi.org/10.3892/br.2014.350
MLA
Lerner, C., Wemmert, S., Schick, B."Preliminary analysis of different microRNA expression levels in juvenile angiofibromas". Biomedical Reports 2.6 (2014): 835-838.
Chicago
Lerner, C., Wemmert, S., Schick, B."Preliminary analysis of different microRNA expression levels in juvenile angiofibromas". Biomedical Reports 2, no. 6 (2014): 835-838. https://doi.org/10.3892/br.2014.350
Copy and paste a formatted citation
x
Spandidos Publications style
Lerner C, Wemmert S and Schick B: Preliminary analysis of different microRNA expression levels in juvenile angiofibromas. Biomed Rep 2: 835-838, 2014.
APA
Lerner, C., Wemmert, S., & Schick, B. (2014). Preliminary analysis of different microRNA expression levels in juvenile angiofibromas. Biomedical Reports, 2, 835-838. https://doi.org/10.3892/br.2014.350
MLA
Lerner, C., Wemmert, S., Schick, B."Preliminary analysis of different microRNA expression levels in juvenile angiofibromas". Biomedical Reports 2.6 (2014): 835-838.
Chicago
Lerner, C., Wemmert, S., Schick, B."Preliminary analysis of different microRNA expression levels in juvenile angiofibromas". Biomedical Reports 2, no. 6 (2014): 835-838. https://doi.org/10.3892/br.2014.350
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