Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
November-December 2014 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2014 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Altered glutamate cysteine ligase expression and activity in renal cell carcinoma

  • Authors:
    • Monong Li
    • Zongliang Zhang
    • Jiangshui Yuan
    • Yanlun Zhang
    • Xunbo Jin
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China
  • Pages: 831-834
    |
    Published online on: September 9, 2014
       https://doi.org/10.3892/br.2014.359
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oxidative stress has been linked to the progression of mutations and cancer. Increased glutathione (GSH) contents have been observed in a number of different human cancer tissues. GSH is synthesized de novo in a two‑step process catalyzed by glutamate cysteine ligase (GCL). The present study aimed to investigate whether GCL was associated with renal cell carcinoma (RCC). The protein expression levels of the GCL subunits (catalytic subunit, GCLc; and modulatory subunit, GCLm) and GCL activity were examined in renal cancer tissue. A total of 46 patients fulfilling the RCC criteria of the World Health Organization, revised in 2004, were enrolled. The tumor and adjacent tissues were sampled from all the subjects by surgery. The study demonstrated that GCLc and GCLm protein expression and the GCL activity were significantly increased in the tumor tissue from RCC patients. These results indicate that increased expression and enzymatic activity of GCL is closely associated with RCC and thus, this suggests an important role for GSH in the pathogenesis of RCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Shah D, Aggarwal A, Bhatnagar A, Kiran R and Wanchu A: Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus. Free Radic Res. 45:559–567. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Lusini L, Tripodi SA, Rossi R, et al: Altered glutathione anti-oxidant metabolism during tumor progression in human renal-cell carcinoma. Int J Cancer. 91:55–59. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Ames BN, Shigenaga MK and Gold LS: DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ Health Perspect. 101(Suppl 5): 35–44. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Moller P and Wallin H: Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen species and lipid peroxidation product. Mutat Res. 410:271–290. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Kongara S and Karantza V: The interplay between autophagy and ROS in tumorigenesis. Front Oncol. 2:1712012. View Article : Google Scholar

6 

Kryston TB, Georgiev AB, Pissis P and Georgakilas AG: Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res. 711:193–201. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Eltzschig HK and Carmeliet P: Hypoxia and inflammation. N Engl J Med. 364:656–665. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Yeh CC, Hou MF, Wu SH, et al: A study of glutathione status in the blood and tissues of patients with breast cancer. Cell Biochem Funct. 24:555–559. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Suess E, Malessa S, Ungersböck K, et al: Technetium-99m-d, l-hexaniethylpropyleneamine oxime (HMPAO) uptake and glutathione content in brain tumors. J Nucl Med. 32:1675–1681. 1991.PubMed/NCBI

10 

Grubben MJ, van den Braak CC, Nagengast FM and Peters WH: Low colonic glutathione detoxification capacity in patients at risk for colon cancer. Eur J Clin Invest. 36:188–192. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Peters WH, van Schaik A, Peters JH and van Goor H: Oxidised- and total non-protein bound glutathione and related thiols in gallbladder bile of patients with various gastrointestinal disorders. BMC Gastroenterol. 7:72007. View Article : Google Scholar : PubMed/NCBI

12 

Gupta A, Srivastava S, Prasad R, et al: Oxidative stress in non-small cell lung cancer patients after chemotherapy: association with treatment response. Respirology. 15:349–356. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Almadori G, Bussu F, Galli J, et al: Salivary glutathione and uric acid levels in patients with head and neck squamous cell carcinoma. Head Neck. 29:648–654. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Kearns PR, Pieters R, Rottier MM, Pearson AD and Hall AG: Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood. 97:393–398. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Singh S, Khan AR and Gupta AK: Role of glutathione in cancer pathophysiology and therapeutic interventions. J Exp Ther Oncol. 9:303–316. 2012.PubMed/NCBI

16 

Ziegler DM: Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation. Annu Rev Biochem. 54:305–329. 1985. View Article : Google Scholar : PubMed/NCBI

17 

Huang CS, Chang LS, Anderson ME and Meister A: Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem. 268:19675–19680. 1993.PubMed/NCBI

18 

McConnachie LA, Mohar I, Hudson FN, et al: Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice. Toxicol Sci. 99:628–636. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Dalton TP, Dieter MZ, Yang Y, Shertzer HG and Nebert DW: Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem Biophys Res Commun. 279:324–329. 2000. View Article : Google Scholar

20 

Iida T, Kijima H, Urata Y, et al: Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther. 8:803–814. 2001. View Article : Google Scholar

21 

Eble JN, Sauter G, Epstein JI and Sesterhenn IA: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. 1st edition. IARC Press; Lyon: pp. 12–43. 2004

22 

Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual. 7th edition. Springer; New York, NY: pp. 103–115. 2010

23 

Chen CN, Brown-Borg HM, Rakoczy SG, Ferrington DA and Thompson LV: Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. J Gerontol A Biol Sci Med Sci. 65:129–137. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Franklin CC, Backos DS, Mohar I, White CC, Forman HJ and Kavanagh TJ: Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol Aspects Med. 30:86–98. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Locigno R and Castronovo V: Reduced glutathione system: role in cancer development, prevention and treatment (review). Int J Oncol. 19:221–236. 2001.PubMed/NCBI

26 

Kern JC and Kehrer JP: Free radicals and apoptosis: relationships with glutathione, thioredoxin, and the BCL family of proteins. Front Biosci. 10:1727–1738. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Montero AJ and Jassem J: Cellular redox pathways as a therapeutic target in the treatment of cancer. Drugs. 71:1385–1396. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Solinas G, Marchesi F, Garlanda C, Mantovani A and Allavena P: Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev. 29:243–248. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Maher P: The effects of stress and aging on glutathione metabolism. Ageing Res Rev. 4:288–314. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Yuan J, Zhang Z, Li L and Song W: Resveratrol affects the expression of glutamate cysteine ligase in the kidneys of aged rats. Exp Ther Med. 7:1762–1766. 2014.PubMed/NCBI

31 

Estrela JM, Ortega A and Obrador E: Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci. 43:143–181. 2006. View Article : Google Scholar

32 

Backos DS, Franklin CC and Reigan P: The role of glutathione in brain tumor drug resistance. Biochem Pharmacol. 83:1005–1012. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li M, Zhang Z, Yuan J, Zhang Y and Jin X: Altered glutamate cysteine ligase expression and activity in renal cell carcinoma. Biomed Rep 2: 831-834, 2014.
APA
Li, M., Zhang, Z., Yuan, J., Zhang, Y., & Jin, X. (2014). Altered glutamate cysteine ligase expression and activity in renal cell carcinoma. Biomedical Reports, 2, 831-834. https://doi.org/10.3892/br.2014.359
MLA
Li, M., Zhang, Z., Yuan, J., Zhang, Y., Jin, X."Altered glutamate cysteine ligase expression and activity in renal cell carcinoma". Biomedical Reports 2.6 (2014): 831-834.
Chicago
Li, M., Zhang, Z., Yuan, J., Zhang, Y., Jin, X."Altered glutamate cysteine ligase expression and activity in renal cell carcinoma". Biomedical Reports 2, no. 6 (2014): 831-834. https://doi.org/10.3892/br.2014.359
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Zhang Z, Yuan J, Zhang Y and Jin X: Altered glutamate cysteine ligase expression and activity in renal cell carcinoma. Biomed Rep 2: 831-834, 2014.
APA
Li, M., Zhang, Z., Yuan, J., Zhang, Y., & Jin, X. (2014). Altered glutamate cysteine ligase expression and activity in renal cell carcinoma. Biomedical Reports, 2, 831-834. https://doi.org/10.3892/br.2014.359
MLA
Li, M., Zhang, Z., Yuan, J., Zhang, Y., Jin, X."Altered glutamate cysteine ligase expression and activity in renal cell carcinoma". Biomedical Reports 2.6 (2014): 831-834.
Chicago
Li, M., Zhang, Z., Yuan, J., Zhang, Y., Jin, X."Altered glutamate cysteine ligase expression and activity in renal cell carcinoma". Biomedical Reports 2, no. 6 (2014): 831-834. https://doi.org/10.3892/br.2014.359
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team