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Article

Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model

  • Authors:
    • Voon Kin Chin
    • Kuan Jeang Foong
    • Abdullah Maha
    • Basir Rusliza
    • Mohtarrudin Norhafizah
    • Pei Pei Chong
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor 43400, Malaysia, Department of Pathology, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor 43400, Malaysia, Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor 43400, Malaysia
  • Pages: 869-874
    |
    Published online on: September 15, 2014
       https://doi.org/10.3892/br.2014.365
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Abstract

Local cytokine production is a significant indicator for disease pathogenesis or progression. Previous studies on cytokine production during systemic Candida albicans (C. albicans) infection were solely on kidney or single cell type interaction with C. albicans. Therefore, the present study aimed to assess the early cytokine expression of various target organs (kidney, spleen and brain) over a 72‑h time course during systemic C. albicans infection. The local cytokine profiles of the target organs during systemic C. albicans infection were measured by cytometric bead array and ELISA analysis. The results demonstrated that interleukin‑6 (IL‑6) and IL‑2 were statistically significant (P<0.05) in the spleen at 24 and 72 h post‑infection, whereas in the kidney, IL‑6 and tumor necrosis factor‑α (TNF‑α) were statistically significant (P<0.05) at 24 and 72 h post‑infection and CXCL‑1 and transforming growth factor‑β (TGF‑β) were statistically significant (P<0.05) at 72 h post‑infection. In the brain, IL‑6 and TNF‑α were statistically significant (P<0.05) at 24 and 72 h post‑infection, whereas TGF‑β was statistically significant (P<0.05) at 72 h post‑infection. These findings demonstrate that host immune responses were varied among target organs during systemic C. albicans infection. This could be important for designing targeted immunotherapy against this pathogen through immunomodulatory approaches in future exploratory research.
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1 

Dinarello CA: Proinflammatory cytokines. Chest. 118:503–508. 2000. View Article : Google Scholar

2 

Meager T: The Molecular Biology of Cytokines. John Wiley & Sons; Chichester, UK: pp. 1–21. 1998

3 

Abbas AK, Lichtman AH and Pober JS: Cellular and Molecular Immunology. 3rd edition. W.B. Saunders; Philadelphia, PA: pp. 15–37. 1997

4 

Fernández-Arenas E, Cabezón V, Bermejo C, Arroyo J, Nombela C, Diez-Orejas R and Gil C: Integrated proteomics and genomics strategies bring new insight into Candida albicans response upon macrophage interaction. Mol Cell Proteomics. 6:460–478. 2007.PubMed/NCBI

5 

Brieland J, Essig D, Jackson C, Frank D, Loebenberg D, Menzel F, Arnold B, DiDomenico B and Hare R: Comparison of pathogenesis and host immune responses to Candida glabrata and Candida albicans in systemically infected immunocompetent mice. Infect Immun. 69:5046–5055. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Spellberg B, Ibrahim AS, Edwards JE Jr and Filler SG: Mice with disseminated candidiasis die of progressive sepsis. J Infect Dis. 192:336–343. 2005. View Article : Google Scholar : PubMed/NCBI

7 

MacCallum DM, Castillo L, Brown AJ, Gow NA and Odds FC: Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections. PLoS One. 4:e64202009. View Article : Google Scholar : PubMed/NCBI

8 

Fradin C, De Groot P, MacCallum D, Schaller M, Klis F, Odds FC and Hube B: Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol. 56:397–415. 2005. View Article : Google Scholar : PubMed/NCBI

9 

MacCallum DM: Massive induction of innate immune response to Candida albicans in the kidney in a murine intravenous challenge model. FEMS Yeast Res. 9:1111–1122. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Kim HS, Choi EH, Khan J, Roilides E, Francesconi A, Kasai M, Sein T, Schaufele RL, Sakurai K, Son CG, Greer BT, Chanock S, Lyman CA and Walsh TJ: Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans. Infect Immun. 73:3714–3724. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Mathey E, Pollard J and Armati P: In situ hybridization for cytokines in human tissue biopsies. Methods Mol Biol. 249:41–46. 2003.PubMed/NCBI

12 

Edwards BS, Oprea T, Prossnitz ER and Sklar LA: Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol. 8:392–398. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Diaz MR, Boekhout T, Theelen B, Bovers M, Cabañes FJ and Fell JW: Microcoding and flow cytometry as a high-throughput fungal identification system for Malassezia species. J Med Microbiol. 55:1197–1209. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Ashman RB and Papadimitriou JM: Production and function of cytokines in natural and acquired immunity to Candida albicans infection. Microbiol Rev. 59:646–672. 1995.PubMed/NCBI

15 

Moseley TA, Haudenschild DR, Rose L and Reddi AH: Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 14:155–174. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Kolls JK and Lindén A: Interleukin-17 family members and inflammation. Immunity. 21:467–476. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Huang W, Na L, Fidel PL and Schwarzenberger P: Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis. 190:624–631. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Blobe GC, Schiemann WP and Lodish HF: Role of transforming growth factor beta in human disease. N Engl J Med. 342:1350–1358. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Letterio JJ and Roberts AB: Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137–161. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Vodovotz Y, Bogdan C, Paik J, Xie QW and Nathan C: Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J Exp Med. 178:605–613. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Letterio JJ, Lehrnbecher T, Pollack G, Walsh TJ and Chanock SJ: Invasive candidiasis stimulates hepatocyte and monocyte production of active transforming growth factor beta. Infect Immun. 69:5115–5120. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Silva JS, Twardzik DR and Reed SG: Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta). J Exp Med. 174:539–545. 1991.

23 

Barral A, Barral-Netto M, Yong EC, Brownell CE, Twardzik DR and Reed SG: Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis. Proc Natl Acad Sci USA. 90:3442–3446. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Gorelik L and Flavell RA: Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 12:171–181. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Beno DW and Mathews HL: Growth inhibition of Candida albicans by interleukin-2-activated splenocytes. Infect Immun. 60:853–863. 1992.

26 

Levitz SM and Dupont MP: Phenotypic and functuional characterization of human lymphocytes activated by interleukin-2 to directly inhibit growth of Crytococcus neoformans in vitro. J Clin Invest. 91:1490–1498. 1993. View Article : Google Scholar : PubMed/NCBI

27 

De Filippo K, Henderson RB, Laschinger M and Hogg N: Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. J Immunol. 180:4308–4315. 2008.PubMed/NCBI

28 

Djeu JY, Blanchard DK, Halkis D and Friedman H: Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor. J Immunol. 137:2980–2984. 1986.PubMed/NCBI

29 

Ferrante A: Tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: increased fungicidal activity against Torulopsis glabrata and Candida albicans and associated increases in oxygen radical production and lysosomal enzyme release. Infect Immun. 57:2115–2122. 1989.

30 

Marshall JD, Heeke DS, Abbate C, Yee P and Van Nest G: Induction of interferon-gamma from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid-dendritic-cell-produced interferon-alpha and tumour necrosis factor-alpha. Immunology. 117:38–46. 2006. View Article : Google Scholar

31 

Grau GE, Heremans H, Piguet PF, Pointaire P, Lambert PH, Billiau A and Vassalli P: Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc Natl Acad Sci USA. 86:5572–5574. 1989. View Article : Google Scholar

32 

de Kossodo S and Grau GE: Profiles of cytokine production in relation with susceptibility to cerebral malaria. J Immunol. 151:4811–4820. 1993.PubMed/NCBI

33 

Kwiatkowski D, Hill AV, Sambou I, Twumasi P, Castracane J, Manogue KR, Cerami A, Brewster DR and Greenwood BM: TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet. 336:1201–1204. 1990. View Article : Google Scholar : PubMed/NCBI

34 

Wolfs TG, Buurman WA, van Schadewijk A, de Vries B, Daemen MA, Hiemstra PS and van’t Veer C: In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J Immunol. 168:1286–1293. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Mencacci A, Cenci E, Del Sero G, Fe d’Ostiani C, Mosci P, Montagnoli C, Bacci A, Bistoni F, Quesniaux VF, Ryffel B and Romani L: Defective co-stimulation and impaired Th1 development in tumor necrosis factor/lymphotoxin-alpha double-deficient mice infected with Candida albicans. Int Immunol. 10:37–48. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Romani L, Mencacci A, Cenci E, Spaccapelo R, Toniatti C, Puccetti P, Bistoni F and Poli V: Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J Exp Med. 183:1345–1355. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Van Snick J: Interleukin-6: an overview. Annu Rev Immunol. 8:253–278. 1990.

38 

Khong WX, Foo DG, Trasti SL, Tan EL and Alonso S: Sustained high levels of interleukin-6 contribute to the pathogenesis of enterovirus 71 in a neonate mouse model. J Virol. 85:3067–3076. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Tanaka T, Kanda T, McManus BM, Kanai H, Akiyama H, Sekiguchi K, Yokoyama T and Kurabayashi M: Overexpression of interleukin-6 aggravates viral myocarditis: impaired increase in tumor necrosis factor-alpha. J Mol Cell Cardiol. 33:1627–1635. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chin VK, Foong KJ, Maha A, Rusliza B, Norhafizah M and Chong PP: Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model. Biomed Rep 2: 869-874, 2014.
APA
Chin, V.K., Foong, K.J., Maha, A., Rusliza, B., Norhafizah, M., & Chong, P.P. (2014). Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model. Biomedical Reports, 2, 869-874. https://doi.org/10.3892/br.2014.365
MLA
Chin, V. K., Foong, K. J., Maha, A., Rusliza, B., Norhafizah, M., Chong, P. P."Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model". Biomedical Reports 2.6 (2014): 869-874.
Chicago
Chin, V. K., Foong, K. J., Maha, A., Rusliza, B., Norhafizah, M., Chong, P. P."Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model". Biomedical Reports 2, no. 6 (2014): 869-874. https://doi.org/10.3892/br.2014.365
Copy and paste a formatted citation
x
Spandidos Publications style
Chin VK, Foong KJ, Maha A, Rusliza B, Norhafizah M and Chong PP: Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model. Biomed Rep 2: 869-874, 2014.
APA
Chin, V.K., Foong, K.J., Maha, A., Rusliza, B., Norhafizah, M., & Chong, P.P. (2014). Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model. Biomedical Reports, 2, 869-874. https://doi.org/10.3892/br.2014.365
MLA
Chin, V. K., Foong, K. J., Maha, A., Rusliza, B., Norhafizah, M., Chong, P. P."Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model". Biomedical Reports 2.6 (2014): 869-874.
Chicago
Chin, V. K., Foong, K. J., Maha, A., Rusliza, B., Norhafizah, M., Chong, P. P."Early expression of local cytokines during systemic Candida albicans infection in a murine intravenous challenge model". Biomedical Reports 2, no. 6 (2014): 869-874. https://doi.org/10.3892/br.2014.365
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