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Article

Association of a transcription factor 21 gene polymorphism with hypertension

  • Authors:
    • Tetsuo Fujimaki
    • Mitsutoshi Oguri
    • Hideki Horibe
    • Kimihiko Kato
    • Reiko Matsuoka
    • Shintaro Abe
    • Fumitaka Tokoro
    • Masazumi Arai
    • Toshiyuki Noda
    • Sachiro Watanabe
    • Yoshiji Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie 511‑0428, Japan, Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Aichi 453‑8511, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507‑8522, Japan, Department of Internal Medicine, Meitoh Hospital, Nagoya, Aichi 465‑0025, Japan, Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Gigu 500‑8717, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514‑8507, Japan
  • Pages: 118-122
    |
    Published online on: October 13, 2014
       https://doi.org/10.3892/br.2014.371
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Abstract

Various loci and genes that confer susceptibility to coronary artery disease (CAD) have been identified mainly in Caucasian populations by genome‑wide association studies (GWASs). As hypertension is a major risk factor for CAD, certain polymorphisms may contribute to the genetic susceptibility to CAD through affecting the predisposition to hypertension. The aim of the present study was to examine a possible association of hypertension with 29 single‑nucleotide polymorphisms (SNPs) previously identified by meta‑analyses of GWASs as susceptibility loci for CAD. Study subjects comprised of 5,460 individuals (3,348 subjects with hypertension and 2,112 controls). The genotypes of SNPs were determined by the multiplex bead‑based Luminex assay. The χ2 test revealed that genotype distributions and allele frequencies for rs12190287 of the transcription factor 21 gene (TCF21) and rs1122608 of the SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 gene (SMARCA4) were significantly (P<0.05) associated with hypertension. Allele frequencies for rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1) and genotype distributions for rs599839 of the proline/serine‑rich coiled‑coil 1 gene (PSRC1) were also significantly associated with hypertension. Multivariable logistic regression analysis with adjustment for age, gender, body mass index and smoking status revealed that rs12190287 of TCF21 (P=0.0014; recessive model; odds ratio, 1.21) was significantly associated with hypertension, and the C allele represented a risk factor for this condition. Similar analyses revealed that rs1122608 of SMARCA4 (P=0.0305; dominant model; odds ratio, 0.86), rs9369640 of PHACTR1 (P=0.0119; dominant model; odds ratio, 0.82) and rs599839 of PSRC1 (P=0.0248; dominant model; odds ratio, 0.84) were also related to hypertension, with the minor T, C and G alleles, respectively, being protective against this condition. Thus, the present results indicate that rs12190287 (G→C) of TCF21 is a susceptibility locus for hypertension.
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1 

Kearney PM, Whelton M, Reynolds K, et al: Global burden of hypertension: analysis of worldwide data. Lancet. 365:217–223. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Schunkert H, Konig IR, Kathiresan S, et al: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43:333–338. 2011. View Article : Google Scholar : PubMed/NCBI

3 

CARDIoGRAMplusC4D Consortium, . Deloukas P, Kanoni S, et al: Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 45:25–33. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M and Morgenstern BZ: Human blood pressure determination by sphygmomanometry. Circulation. 88:2460–2470. 1993. View Article : Google Scholar : PubMed/NCBI

5 

Yamada Y, Fuku N, Tanaka M, et al: Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 207:144–149. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Yamada Y, Nishida T, Ichihara S, et al: Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. Atherosclerosis. 215:145–152. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Yamada Y, Nishida T, Ichihara S, et al: Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study. J Med Genet. 50:410–418. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Itoh Y, Mizuki N, Shimada T, et al: High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics. 57:717–729. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Wellcome Trust Case Control Consortium, . Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 447:661–678. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Newton-Cheh C, Johnson T, Gateva V, et al: Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 41:666–676. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Levy D, Ehret GB, Rice K, et al: Genome-wide association study of blood pressure and hypertension. Nat Genet. 41:677–687. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Org E, Eyheramendy S, Juhanson P, et al: Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet. 18:2288–2296. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Tragante V, Barnes MR, Ganesh SK, et al: Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet. 94:349–360. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Adeyemo A, Gerry N, Chen G, et al: A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet. 5:e10005642009. View Article : Google Scholar : PubMed/NCBI

15 

Funato N, Ohyama K, Kuroda T and Nakamura M: Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription. J Biol Chem. 278:7486–7493. 2003. View Article : Google Scholar

16 

Smith LT, Lin M, Brena RM, et al: Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. Proc Natl Acad Sci USA. 103:982–987. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Miller CL, Anderson DR, Kundu RK, et al: Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS Genet. 9:e10036522013. View Article : Google Scholar : PubMed/NCBI

18 

Bond M, Sala-Newby GB, Wu YJ and Newby AC: Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation. Cardiovasc Res. 69:198–206. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Feihl F, Liaudet L, Levy BI and Waeber B: Hypertension and microvascular remodelling. Cardiovasc Res. 78:274–285. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Peterson CL: Chromatin remodeling: nucleosome bulging at the seams. Curr Biol. 12:R245–R247. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Zhou J, Zhang M, Fang H, et al: The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol. 29:921–928. 2009. View Article : Google Scholar

22 

Hendricks KB, Shanahan F and Lees E: Role for BRG1 in cell cycle control and tumor suppression. Mol Cell Biol. 24:362–376. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC and Greengard P: Phactrs 1–4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci USA. 101:7187–7192. 2004. View Article : Google Scholar

24 

Fils-Aime N, Dai M, Guo J, El-Mousawi M, Kahramangil B, Neel JC and Lebrun JJ: MicroRNA-584 and the protein phosphatase and actin regulator 1 (PHACTR1), a new signaling route through which transforming growth factor-β mediates the migration and actin dynamics of breast cancer cells. J Biol Chem. 288:11807–11823. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Mount PF, Kemp BE and Power DA: Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol. 42:271–279. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Jang CY and Fang G: The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3. Cell Cycle. 8:3165–3171. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Kathiresan S, Melander O, Guiducci C, et al: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 40:189–197. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fujimaki T, Oguri M, Horibe H, Kato K, Matsuoka R, Abe S, Tokoro F, Arai M, Noda T, Watanabe S, Watanabe S, et al: Association of a transcription factor 21 gene polymorphism with hypertension. Biomed Rep 3: 118-122, 2015.
APA
Fujimaki, T., Oguri, M., Horibe, H., Kato, K., Matsuoka, R., Abe, S. ... Yamada, Y. (2015). Association of a transcription factor 21 gene polymorphism with hypertension. Biomedical Reports, 3, 118-122. https://doi.org/10.3892/br.2014.371
MLA
Fujimaki, T., Oguri, M., Horibe, H., Kato, K., Matsuoka, R., Abe, S., Tokoro, F., Arai, M., Noda, T., Watanabe, S., Yamada, Y."Association of a transcription factor 21 gene polymorphism with hypertension". Biomedical Reports 3.1 (2015): 118-122.
Chicago
Fujimaki, T., Oguri, M., Horibe, H., Kato, K., Matsuoka, R., Abe, S., Tokoro, F., Arai, M., Noda, T., Watanabe, S., Yamada, Y."Association of a transcription factor 21 gene polymorphism with hypertension". Biomedical Reports 3, no. 1 (2015): 118-122. https://doi.org/10.3892/br.2014.371
Copy and paste a formatted citation
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Spandidos Publications style
Fujimaki T, Oguri M, Horibe H, Kato K, Matsuoka R, Abe S, Tokoro F, Arai M, Noda T, Watanabe S, Watanabe S, et al: Association of a transcription factor 21 gene polymorphism with hypertension. Biomed Rep 3: 118-122, 2015.
APA
Fujimaki, T., Oguri, M., Horibe, H., Kato, K., Matsuoka, R., Abe, S. ... Yamada, Y. (2015). Association of a transcription factor 21 gene polymorphism with hypertension. Biomedical Reports, 3, 118-122. https://doi.org/10.3892/br.2014.371
MLA
Fujimaki, T., Oguri, M., Horibe, H., Kato, K., Matsuoka, R., Abe, S., Tokoro, F., Arai, M., Noda, T., Watanabe, S., Yamada, Y."Association of a transcription factor 21 gene polymorphism with hypertension". Biomedical Reports 3.1 (2015): 118-122.
Chicago
Fujimaki, T., Oguri, M., Horibe, H., Kato, K., Matsuoka, R., Abe, S., Tokoro, F., Arai, M., Noda, T., Watanabe, S., Yamada, Y."Association of a transcription factor 21 gene polymorphism with hypertension". Biomedical Reports 3, no. 1 (2015): 118-122. https://doi.org/10.3892/br.2014.371
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