Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
January-February 2015 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2015 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus

  • Authors:
    • Fumitaka Tokoro
    • Reiko Matsuoka
    • Shintaro Abe
    • Masazumi Arai
    • Toshiyuki Noda
    • Sachiro Watanabe
    • Hideki Horibe
    • Tetsuo Fujimaki
    • Mitsutoshi Oguri
    • Kimihiko Kato
    • Shinya Minatoguchi
    • Yoshiji Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Gifu Prefectural General Medical Center, Gifu 500‑8717, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507‑8522, Japan, Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie 511‑0428, Japan, Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Aichi 453‑8511, Japan, Department of Internal Medicine, Meitoh Hospital, Nagoya, Aichi 465-0025, Japan, Department of Cardiology, Gifu University Graduate School of Medicine, Gifu 501‑1194, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514‑8507, Japan
  • Pages: 88-92
    |
    Published online on: November 7, 2014
       https://doi.org/10.3892/br.2014.379
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Various loci and genes that confer susceptibility to coronary heart disease (CHD) have been identified in Caucasian populations by genome‑wide association studies (GWASs). As type 2 diabetes mellitus (DM) is an important risk factor for CHD, we hypothesized that certain polymorphisms may contribute to the genetic susceptibility to CHD through affecting the susceptibility to type 2 DM. The purpose of the present study was to examine a possible association of type 2 DM in Japanese individuals with 29 polymorphisms identified as susceptibility loci for CHD by meta‑analyses of the GWASs. The study subjects comprised of 3,757 individuals (1,444 subjects with type 2 DM and 2,313 controls). The polymorphism genotypes were determined by the multiplex bead‑based Luminex assay, which combines the polymerase chain reaction and sequence‑specific oligonucleotide probes with suspension array technology. To compensate for multiple comparisons of genotypes, the criterion of a false discovery rate (FDR) ≤0.05 was adopted for testing the statistical significance of the association. The comparisons of allele frequencies by the χ2 test revealed that the rs964184 (C→G) of the ZPR1 zinc finger gene (ZPR1) was significantly associated (P=0.0017; FDR=0.050) with type 2 DM. Multivariable logistic regression analysis with adjustment for age, gender and body mass index revealed that rs964184 of ZPR1 was significantly associated (P=0.0012; odds ratio, 1.25; dominant model) with type 2 DM with the minor G allele representing a risk factor for this condition. Fasting plasma glucose levels (P=0.0076) and blood glycosylated hemoglobin contents (P=0.0132) significantly differed among ZPR1 genotypes with the G allele associated with increases in these parameters. ZPR1 may thus be a susceptibility locus for type 2 DM in Japanese individuals.
View Figures
View References

1 

Unwin N, Gan D and Whiting D: The IDF Diabetes Atlas: proving evidence, raising awareness and promoting action. Diabetes Res Clin Pract. 87:2–3. 2010. View Article : Google Scholar

2 

Hu FB: Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 34:1249–1257. 2011. View Article : Google Scholar : PubMed/NCBI

3 

McCarthy MI: Genomics, type 2 diabetes, and obesity. N Engl J Med. 363:2339–2350. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Shu XO, Long J, Cai Q, et al: Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 6:e10011272010. View Article : Google Scholar : PubMed/NCBI

5 

Kooner JS, Saleheen D, Sim X, et al: Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 43:984–989. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Cho YS, Chen CH, Hu C, et al: Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians. Nat Genet. 44:67–72. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Prokopenko I, McCarthy MI and Lindgren CM: Type 2 diabetes: new genes, new understanding. Trends Genet. 24:613–621. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Tabassum R, Chauhan G, Dwivedi OP, et al: Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes. 62:977–986. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Sladek R, Rocheteau G, Rung J, et al: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 445:881–885. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Yasuda K, Miyake K, Horikawa Y, et al: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet. 40:1092–1097. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Yamauchi T, Hara K, Maeda S, et al: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet. 42:864–868. 2010. View Article : Google Scholar : PubMed/NCBI

12 

McCarthy MI: The importance of global studies of the genetics of type 2 diabetes. Diabetes Metab J. 35:91–100. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Schunkert H, Konig IR, Kathiresan S, et al: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43:333–338. 2011. View Article : Google Scholar : PubMed/NCBI

14 

CARDIoGRAMplusC4D Consortium, . Deloukas P, Kanoni S, et al: Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 45:25–33. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Expert Committee on the Diagnosis. Classification of Diabetes Mellitus: Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 26 (Suppl 1):S5–S20. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Kuzuya T, Nakagawa S, Satoh J, et al: Report of the Committee on the classification and diagnosis criteria of diabetes mellitus. Diabetes Res Clin Pract. 55:65–85. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Itoh Y, Mizuki N, Shimada T, et al: High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics. 57:717–729. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Galcheva-Gargova Z, Konstantinov KN, Wu IH, et al: Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science. 272:1797–1802. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Galcheva-Gargova Z, Gangwani L, Konstantinov KN, et al: The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Mol Biol Cell. 9:2963–2971. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Mangelsdorf DJ, Thummel C, Beato M, et al: The nuclear receptor superfamily: the second decade. Cell. 83:835–839. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Corton JC, Anderson SP, Stauber A, et al: Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol. 40:491–518. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Sladek FM, Zhong WM, Lai E, et al: Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353–2365. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Teslovich TM, Musunuru K, Smith AV, et al: Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 466:707–713. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Kathiresan S, Willer CJ, Peloso GM, et al: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 41:56–65. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Willer CJ, Sanna S, Jackson AU, et al: Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 40:161–169. 2008. View Article : Google Scholar

26 

Waterworth DM, Ricketts SL, Song K, et al: Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol. 30:2264–2276. 2010. View Article : Google Scholar : PubMed/NCBI

27 

O'Brien PJ, Alborn WE, Sloan JH, et al: The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. Clin Chem. 51:351–359. 2005.

28 

Bernstein RM, Davis BM, Olefsky JM, et al: Hepatic insulin responsiveness in patients with endogenous hypertriglyceridaemia. Diabetologia. 14:249–253. 1978. View Article : Google Scholar : PubMed/NCBI

29 

Talmud PJ, Cooper JA, Hattori H, et al: The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II. Diabetologia. 49:2337–2340. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Soter MO, Gomes KB, Fernandes AP, et al: −1131T>C and SW19 polymorphisms in APOA5 gene and lipid levels in type 2 diabetic patients. Mol Biol Rep. 39:7541–7548. 2012. View Article : Google Scholar

31 

Yin YW, Sun QQ, Wang PJ, et al: Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects. PLoS One. 9:e891672014. View Article : Google Scholar : PubMed/NCBI

32 

Kristiansson K, Perola M, Tikkanen E, et al: Genome-wide screen for metabolic syndrome susceptibility loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet. 5:242–249. 2012. View Article : Google Scholar

33 

van de Woestijne AP, van der Graaf Y, de Bakker PI, et al: Rs964184 (APOA5-A4-C3-A1) is related to elevated plasma triglyceride levels, but not to an increased risk for vascular events in patient with clinically manifest vascular disease. PLoS One. 9:e1010822014.

34 

Johansen CT, Wang J, Lanktree MB, et al: Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet. 42:684–687. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tokoro F, Matsuoka R, Abe S, Arai M, Noda T, Watanabe S, Horibe H, Fujimaki T, Oguri M, Kato K, Kato K, et al: Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus. Biomed Rep 3: 88-92, 2015.
APA
Tokoro, F., Matsuoka, R., Abe, S., Arai, M., Noda, T., Watanabe, S. ... Yamada, Y. (2015). Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus. Biomedical Reports, 3, 88-92. https://doi.org/10.3892/br.2014.379
MLA
Tokoro, F., Matsuoka, R., Abe, S., Arai, M., Noda, T., Watanabe, S., Horibe, H., Fujimaki, T., Oguri, M., Kato, K., Minatoguchi, S., Yamada, Y."Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus". Biomedical Reports 3.1 (2015): 88-92.
Chicago
Tokoro, F., Matsuoka, R., Abe, S., Arai, M., Noda, T., Watanabe, S., Horibe, H., Fujimaki, T., Oguri, M., Kato, K., Minatoguchi, S., Yamada, Y."Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus". Biomedical Reports 3, no. 1 (2015): 88-92. https://doi.org/10.3892/br.2014.379
Copy and paste a formatted citation
x
Spandidos Publications style
Tokoro F, Matsuoka R, Abe S, Arai M, Noda T, Watanabe S, Horibe H, Fujimaki T, Oguri M, Kato K, Kato K, et al: Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus. Biomed Rep 3: 88-92, 2015.
APA
Tokoro, F., Matsuoka, R., Abe, S., Arai, M., Noda, T., Watanabe, S. ... Yamada, Y. (2015). Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus. Biomedical Reports, 3, 88-92. https://doi.org/10.3892/br.2014.379
MLA
Tokoro, F., Matsuoka, R., Abe, S., Arai, M., Noda, T., Watanabe, S., Horibe, H., Fujimaki, T., Oguri, M., Kato, K., Minatoguchi, S., Yamada, Y."Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus". Biomedical Reports 3.1 (2015): 88-92.
Chicago
Tokoro, F., Matsuoka, R., Abe, S., Arai, M., Noda, T., Watanabe, S., Horibe, H., Fujimaki, T., Oguri, M., Kato, K., Minatoguchi, S., Yamada, Y."Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus". Biomedical Reports 3, no. 1 (2015): 88-92. https://doi.org/10.3892/br.2014.379
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team