Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device

Wu,Xin; Li,Yubo; Xu,Daoqing; Zhou,Hong; Wang,Jinlei; Guo,Xuejun; Zhang,Yanjun

doi:10.3892/br.2014.382

January-February 2015 Volume 3 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January-February 2015 Volume 3 Issue 1

Full Size Image

Article

Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device

Authors:
- Xin Wu
- Yubo Li
- Daoqing Xu
- Hong Zhou
- Jinlei Wang
- Xuejun Guo
- Yanjun Zhang
View Affiliations / Copyright

Affiliations: School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China, Tianjin Zhongxin Pharmaceutical Group Corporation Limited, Tianjin 300193, P.R. China, No.6 Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Co., Qingguang North, Tianjin 300401, P.R. China
Pages: 51-54
|
Published online on: November 11, 2014

https://doi.org/10.3892/br.2014.382
Expand metrics +

Abstract

The aim of the present study was to investigate the characteristics of Su Xiao Jiu Xin dripping pill absorption in the buccal mucosa of healthy volunteers. This pill is a traditional Chinese medicine that is widely used as an emergency treatment for cardiovascular and cerebrovascular diseases. It is sublingually administered and can be absorbed in the buccal mucosa. In the present study, a method was developed to investigate the absorption characteristics in the buccal mucosa of healthy volunteers via a circulating device by gas chromatography‑mass spectrometry and high‑performance liquid chromatography. The five main efficacy components associated with cardiovascular and cerebrovascular diseases, which are borneol, isoborneol, ligustilide, n‑butylphthalide and ferulic acid, were detected and rapidly absorbed. Among these components, four exhibited good absorption, thus confirming that the method developed is efficient for analysis of the absoption characteristics.

View Figures

View References

1	Sun SR, Huang X and Zhang L: Advances in studies on pharmacokinetics, pharmacodynamics and clinical research of Su Xiao Jiu Xin Wan. Chin Tradit Herb Drugs. 33:89–91. 2002.
2	Wei Y, Huang W and Gu Y: Online isolation and purification of four phthalide compounds from Chuanxiong rhizoma using high-speed counter-current chromatography coupled with semi-preparative liquid chromatography. J Chromatogr A. 1284:53–58. 2013. View Article : Google Scholar : PubMed/NCBI
3	Alaerts G, Merino-Arevalo M, Dumarey M, et al: Exploratory analysis of chromatographic fingerprints to distinguish rhizoma Chuanxiong and rhizoma Ligustici. J Chromatogr A. 1217:7706–7716. 2010. View Article : Google Scholar : PubMed/NCBI
4	Xiang L, Jiang P, Zhan C, et al: The serum metabolomic study of intervention effects of the traditional Chinese medicine Shexiang Baoxin Pill and a multi-component medicine polypill in the treatment of myocardial infarction in rats. Mol BioSyst. 8:2434–2442. 2012. View Article : Google Scholar
5	Diao X, Deng P, Xie C, et al: Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. Drug Metab Dispos. 41:430–444. 2013. View Article : Google Scholar : PubMed/NCBI
6	Feng Z, Lu Y, Wu X, et al: Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. J Ethnopharmacol. 144:313–321. 2012. View Article : Google Scholar : PubMed/NCBI
7	Alam MA, Sernia C and Brown L: Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats. J Cardiovasc Pharmacol. 61:240–249. 2013. View Article : Google Scholar : PubMed/NCBI
8	Patel VF, Liu F and Brown MB: Modeling the oral cavity: in vitro and in vivo evaluations of buccal drug delivery systems. J Control Release. 161:746–756. 2012. View Article : Google Scholar
9	Campisi G, Paderni C, Saccone R, Di Fede O, Wolff A and Giannola LI: Human buccal mucosa as an innovative site of drug delivery. Curr Pharm Des. 16:641–652. 2010. View Article : Google Scholar : PubMed/NCBI
10	Adrian CL, Olin HB, Dalhoff K and Jacobsen J: In vivo human buccal permeability of nicotine. Int J Pharm. 311:196–202. 2006. View Article : Google Scholar
11	Zhang X, Wang L, Yang X, et al: Study on the correlation between buccal absorption in healthy volunteers and release rate in vitro of Glycyrrhizin in Qingyan Drop Pills. Chin Med J Res Prac. 24:60–61. 2010.
12	Senel S and Hincal AA: Drug permeation enhancement via buccal route: possibilities and limitations. J Control Release. 72:133–144. 2001. View Article : Google Scholar : PubMed/NCBI
13	Yuji K and Toshikiro K: Drug absorption by oral mucosa-mechanism of absorption and promoter. Int. J Clin Exp Med. 145-147:468–470. 1988.
14	Zhou Y, Li W, Chen L, Ma S, Ping L and Yang Z: Enhancement of intestinal absorption of akebia saponin D by borneol and probenecid in situ and in vitro. Environ Toxicol Pharmacol. 29:229–234. 2010. View Article : Google Scholar : PubMed/NCBI
15	Leon-Carmona JR, Alvarez-Idaboy JR and Galano A: On the peroxyl scavenging activity of hydroxycinnamic acid derivatives: mechanisms, kinetics, and importance of the acid-base equilibrium. Phys Chem Chem Phys. 14:12534–12543. 2012. View Article : Google Scholar : PubMed/NCBI
16	Bikov A, Galffy G, Tamasi L, Lazar Z, Losonczy G and Horvath I: Exhaled breath condensate pH is influenced by respiratory droplet dilution. J Breath Res. 6:0460022012. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles