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Article

Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines

  • Authors:
    • Eli Halimah
    • Ajeng Diantini
    • Dika P. Destiani
    • Ivan S. Pradipta
    • Herri S. Sastramihardja
    • Keri Lestari
    • Anas Subarnas
    • Rizky Abdulah
    • Hiroshi Koyama

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java 45363, Indonesia, Department of Clinical Pharmacology, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, West Java 45363, Indonesia, Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma 371‑8511, Japan
  • Pages: 115-117
    |
    Published online on: November 14, 2014
       https://doi.org/10.3892/br.2014.385
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Abstract

Prostate cancer has become a leading cause of mortality in humans. Previous studies have shown the potential anticancer properties of kaempferol‑3‑O‑rhamnoside in breast cancer cell lines. In the present study, the anticancer potential of kaempferol‑3‑O‑rhamnoside was investigated in LNCaP human prostate cancer cell lines. The inhibition of cell proliferation was investigated using MTT assays, whereas its ability to induce the caspase‑cascade pathway was investigated by western blotting. The results showed that kaempferol‑3‑O‑rhamnoside inhibits the proliferation of LNCaP cells in a dose‑dependent manner by upregulating the expression of caspase‑8, caspase‑9, caspase‑3 and poly (ADP‑ribose) polymerase proteins. Although further studies are required, the results of the present study indicate the potential application of kaempferol‑3‑O‑rhamnoside in cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Halimah E, Diantini A, Destiani DP, Pradipta IS, Sastramihardja HS, Lestari K, Subarnas A, Abdulah R and Koyama H: Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines. Biomed Rep 3: 115-117, 2015.
APA
Halimah, E., Diantini, A., Destiani, D.P., Pradipta, I.S., Sastramihardja, H.S., Lestari, K. ... Koyama, H. (2015). Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines. Biomedical Reports, 3, 115-117. https://doi.org/10.3892/br.2014.385
MLA
Halimah, E., Diantini, A., Destiani, D. P., Pradipta, I. S., Sastramihardja, H. S., Lestari, K., Subarnas, A., Abdulah, R., Koyama, H."Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines". Biomedical Reports 3.1 (2015): 115-117.
Chicago
Halimah, E., Diantini, A., Destiani, D. P., Pradipta, I. S., Sastramihardja, H. S., Lestari, K., Subarnas, A., Abdulah, R., Koyama, H."Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines". Biomedical Reports 3, no. 1 (2015): 115-117. https://doi.org/10.3892/br.2014.385
Copy and paste a formatted citation
x
Spandidos Publications style
Halimah E, Diantini A, Destiani DP, Pradipta IS, Sastramihardja HS, Lestari K, Subarnas A, Abdulah R and Koyama H: Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines. Biomed Rep 3: 115-117, 2015.
APA
Halimah, E., Diantini, A., Destiani, D.P., Pradipta, I.S., Sastramihardja, H.S., Lestari, K. ... Koyama, H. (2015). Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines. Biomedical Reports, 3, 115-117. https://doi.org/10.3892/br.2014.385
MLA
Halimah, E., Diantini, A., Destiani, D. P., Pradipta, I. S., Sastramihardja, H. S., Lestari, K., Subarnas, A., Abdulah, R., Koyama, H."Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines". Biomedical Reports 3.1 (2015): 115-117.
Chicago
Halimah, E., Diantini, A., Destiani, D. P., Pradipta, I. S., Sastramihardja, H. S., Lestari, K., Subarnas, A., Abdulah, R., Koyama, H."Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines". Biomedical Reports 3, no. 1 (2015): 115-117. https://doi.org/10.3892/br.2014.385
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