|
1
|
Hua R, Shi J, Wang X, et al: Analysis of
the causes and types of traumatic spinal cord injury based on 561
cases in China from 2001 to 2010. Spinal Cord. 51:218–221. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Cao HQ and Dong ED: An update on spinal
cord injury research. Neurosci Bull. 29:94–102. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Pickelsimer E, Shiroma EJ and Wilson DA:
Statewide investigation of medically attended adverse health
conditions of persons with spinal cord injury. J Spinal Cord Med.
33:221–231. 2010.PubMed/NCBI
|
|
4
|
Huang H, Fan S, Ji X, Zhang Y, Bao F and
Zhang G: Recombinant human erythropoietin protects against
experimental spinal cord trauma injury by regulating expression of
the proteins MKP-1 and p-ERK. J Int Med Res. 37:511–519. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Oyinbo CA: Secondary injury mechanisms in
traumatic spinal cord injury: a nugget of this multiply cascade.
Acta Neurobiol Exp (Wars). 71:281–299. 2011.PubMed/NCBI
|
|
6
|
Nicolas CS, Amici M, Bortolotto ZA, et al:
The role of JAK-STAT signaling within the CNS. JAKSTAT.
2:e229252013.PubMed/NCBI
|
|
7
|
Laurence A, Pesu M, Silvennoinen O and
O'Shea J: JAK kinases in health and disease: an update. Open
Rheumatol J. 6:232–244. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Aittomaki S and Pesu M: Therapeutic
targeting of the Jak/STAT pathway. Basic Clin Pharmacol Toxicol.
114:18–23. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Darnell JE Jr, Kerr IM and Stark GR:
Jak-STAT pathways and transcriptional activation in response to
IFNs and other extracellular signaling proteins. Science.
264:1415–1421. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Shuai K, Horvath CM, Huang LH, Qureshi SA,
Cowburn D and Darnell JE Jr: Interferon activation of the
transcription factor Stat91 involves dimerization through
SH2-phosphotyrosyl peptide interactions. Cell. 76:821–828. 1994.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
O'Shea JJ, Holland SM and Staudt LM: JAKs
and STATs in immunity, immunodeficiency, and cancer. N Engl J Med.
368:161–170. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
O'Shea JJ and Plenge R: JAK and STAT
signaling molecules in immunoregulation and immune-mediated
disease. Immunity. 36:542–550. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Lutticken C, Wegenka UM, Yuan J, Buschmann
J, et al: Association of transcription factor APRF and protein
kinase Jak1 with the interleukin-6 signal transducer gp130.
Science. 263:89–92. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Stahl N, Boulton TG, Farruggella T, et al:
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6
beta receptor components. Science. 263:92–95. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Sadowski HB, Shuai K, Darnell J Jr and
Gilman MZ: A common nuclear signal transduction pathway activated
by growth factor and cytokine receptors. Science. 261:1739–1744.
1993. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhong Z, Wen Z and Darnell JE Jr: Stat3: a
STAT family member activated by tyrosine phosphorylation in
response to epidermal growth factor and interleukin-6. Science.
264:95–98. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Vahedi G, Takahashi H, Nakayamada S, et
al: STATs shape the active enhancer landscape of T cell
populations. Cell. 151:981–993. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Schwaiger FW, Hager G, Schmitt AB, et al:
Peripheral but not central axotomy induces changes in Janus kinases
(JAK) and signal transducers and activators of transcription
(STAT). Eur J Neurosci. 12:1165–1176. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Yao GL, Kato H, Khalil M, Kiryu S and
Kiyama H: Selective upregulation of cytokine receptor subchain and
their intracellular signalling molecules after peripheral nerve
injury. Eur J Neurosci. 9:1047–1054. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Choi JS, Kim SY, Cha JH, et al:
Upregulation of gp130 and STAT3 activation in the rat hippocampus
following transient forebrain ischemia. Glia. 41:237–246. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Suzuki S, Tanaka K, Nogawa S, Dembo T,
Kosakai A and Fukuuchi Y: Phosphorylation of signal transducer and
activator of transcription-3 (Stat3) after focal cerebral ischemia
in rats. Exp Neurol. 170:63–71. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Wen TC, Peng H, Hata R, Desaki J and
Sakanaka M: Induction of phosphorylated-Stat3 following focal
cerebral ischemia in mice. Neurosci Lett. 303:153–156. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Cheng Z, Li L, Mo X, et al: Non-invasive
remote limb ischemic postconditioning protects rats against focal
cerebral ischemia by upregulating STAT3 and reducing apoptosis. Int
J Mol Med. 34:957–966. 2014.PubMed/NCBI
|
|
24
|
Justicia C, Gabriel C and Planas AM:
Activation of the JAK/STAT pathway following transient focal
cerebral ischemia: signaling through Jak1 and Stat3 in astrocytes.
Glia. 30:253–270. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Stromberg H, Svensson SP and Hermanson O:
Distribution of the transcription factor signal transducer and
activator of transcription 3 in the rat central nervous system and
dorsal root ganglia. Brain Res. 853:105–114. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Johansson CB, Momma S, Clarke DL, Risling
M, Lendahl U and Frisen J: Identification of a neural stem cell in
the adult mammalian central nervous system. Cell. 96:25–34. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Takahashi M, Arai Y, Kurosawa H, Sueyoshi
N and Shirai S: Ependymal cell reactions in spinal cord segments
after compression injury in adult rat. J Neuropathol Exp Neurol.
62:185–194. 2003.PubMed/NCBI
|
|
28
|
Bjorklund A and Lindvall O: Self-repair in
the brain. Nature. 405892–893. (895)2000. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Horner PJ, Power AE, Kempermann G, et al:
Proliferation and differentiation of progenitor cells throughout
the intact adult rat spinal cord. J Neurosci. 20:2218–2228.
2000.PubMed/NCBI
|
|
30
|
Lu P, Graham L, Wang Y, Wu D and Tuszynski
M: Promotion of survival and differentiation of neural stem cells
with fibrin and growth factor cocktails after severe spinal cord
injury. J Vis Exp:. 27:e506412014.
|
|
31
|
Tuszynski MH, Wang Y, Graham L, et al:
Neural stem cells in models of spinal cord injury. Exp Neurol.
261C:494–500. 2014. View Article : Google Scholar
|
|
32
|
Natarajan R, Singal V, Benes R, et al:
STAT3 modulation to enhance motor neuron differentiation in human
neural stem cells. PLoS One. 9:e1004052014. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Xiao Q, Du Y, Wu W and Yip HK: Bone
morphogenetic proteins mediate cellular response and, together with
Noggin, regulate astrocyte differentiation after spinal cord
injury. Exp Neurol. 221:353–366. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Bonni A, Sun Y, Nadal-Vicens M, et al:
Regulation of gliogenesis in the central nervous system by the
JAK-STAT signaling pathway. Science. 278:477–483. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
He F, Ge W, Martinowich K, et al: A
positive autoregulatory loop of Jak-STAT signaling controls the
onset of astrogliogenesis. Nat Neurosci. 8:616–625. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Nakanishi M, Niidome T, Matsuda S, Akaike
A, Kihara T and Sugimoto H: Microglia-derived interleukin-6 and
leukaemia inhibitory factor promote astrocytic differentiation of
neural stem/progenitor cells. Eur J Neurosci. 25:649–658. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Nakashima K, Yanagisawa M, Arakawa H, et
al: Synergistic signaling in fetal brain by STAT3-Smad1 complex
bridged by p 300. Science. 284:479–482. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Sriram K, Benkovic SA, Hebert MA, Miller
DB and O'Callaghan JP: Induction of gp130-related cytokines and
activation of JAK2/STAT3 pathway in astrocytes precedes
up-regulation of glial fibrillary acidic protein in the
1-methyl-4-phenyl-1, 2, 3,6-tetrahydropyridine model of
neurodegeneration: key signaling pathway for astrogliosis in vivo?
J Biol Chem. 279:19936–19947. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Taga T, Hibi M, Hirata Y, et al:
Interleukin-6 triggers the association of its receptor with a
possible signal transducer, gp130. Cell. 58:573–581. 1989.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Mangoura D, Pelletiere C, Leung S,
Sakellaridis N and Wang DX: Prolactin concurrently activates
src-PLD and JAK/Stat signaling pathways to induce proliferation
while promoting differentiation in embryonic astrocytes. Int J Dev
Neurosci. 18:693–704. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
David M, Petricoin EF III, Igarashi K,
Feldman GM, Finbloom DS and Larner AC: Prolactin activates the
interferon-regulated p 91 transcription factor and the Jak2 kinase
by tyrosine phosphorylation. Proc Natl Acad Sci USA. 91:7174–7178.
1994. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Dusanter-Fourt I, Muller O, Ziemiecki A,
et al: Identification of JAK protein tyrosine kinases as signaling
molecules for prolactin. Functional analysis of prolactin receptor
and prolactin-erythropoietin receptor chimera expressed in lymphoid
cells. EMBO J. 13:2583–2591. 1994.PubMed/NCBI
|
|
43
|
Gilmour KC and Reich NC: Receptor to
nucleus signaling by prolactin and interleukin 2 via activation of
latent DNA-binding factors. Proc Natl Acad Sci USA. 91:6850–6854.
1994. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Lebrun JJ, Ali S, Sofer L, Ullrich A and
Kelly PA: Prolactin-induced proliferation of Nb2 cells involves
tyrosine phosphorylation of the prolactin receptor and its
associated tyrosine kinase JAK2. J Biol Chem. 269:14021–14026.
1994.PubMed/NCBI
|
|
45
|
Rui H, Djeu JY, Evans GA, Kelly PA and
Farrar WL: Prolactin receptor triggering. Evidence for rapid
tyrosine kinase activation. J Biol Chem. 267:24076–24081.
1992.PubMed/NCBI
|
|
46
|
Rui H, Kirken RA and Farrar WL: Activation
of receptor-associated tyrosine kinase JAK2 by prolactin. J Biol
Chem. 269:5364–5368. 1994.PubMed/NCBI
|
|
47
|
De Vito WJ, Avakian C, Stone S and Okulicz
WC: Prolactin-stimulated mitogenesis of cultured astrocytes is
mediated by a protein kinase C-dependent mechanism. J Neurochem.
60:832–842. 1993.PubMed/NCBI
|
|
48
|
De Vito WJ, Avakian C, Stone S, Okulicz
WC, Tang KT and Shamgochian M: Prolactin induced expression of
interleukin-1 alpha, tumor necrosis factor-alpha, and transforming
growth factor-alpha in cultured astrocytes. J Cell Biochem.
57:290–298. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
De Vito WJ, Okulicz WC, Stone S and
Avakian C: Prolactin-stimulated mitogenesis of cultured astrocytes.
Endocrinology. 130:2549–2556. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
De Vito WJ, Stone S and Mori K: Low
concentrations of ethanol inhibits prolactin-induced mitogenesis
and cytokine expression in cultured astrocytes. Endocrinology.
138:922–928. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
De Vito WJ, Stone S and Shamgochian M:
Prolactin induced expression of glial fibrillary acidic protein and
tumor necrosis factor-alpha at a wound site in the rat brain. Mol
Cell Endocrinol. 108:125–130. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
De Vito WJ and Stone S: Ethanol inhibits
prolactin-induced activation of the JAK/STAT pathway in cultured
astrocytes. J Cell Biochem. 74:278–291. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Cao F, Hata R, Zhu P, Nakashiro K and
Sakanaka M: Conditional deletion of Stat3 promotes neurogenesis and
inhibits astrogliogenesis in neural stem cells. Biochem Biophys Res
Commun. 394:843–847. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Bauer S: Cytokine control of adult neural
stem cells. Ann NY Acad Sci. 1153:48–56. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Gomez-Nicola D, Valle-Argos B,
Pallas-Bazarra N and Nieto-Sampedro M: Interleukin-15 regulates
proliferation and self-renewal of adult neural stem cells. Mol Biol
Cell. 22:1960–1970. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Gupta S, Mishra K, Surolia A and Banerjee
K: Suppressor of cytokine signalling-6 promotes neurite outgrowth
via JAK2/STAT5-mediated signalling pathway, involving negative
feedback inhibition. PLoS One. 6:e266742011. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Turnley AM, Faux CH, Rietze RL, Coonan JR
and Bartlett PF: Suppressor of cytokine signaling 2 regulates
neuronal differentiation by inhibiting growth hormone signaling.
Nat Neurosci. 5:1155–1162. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
58
|
Smith PD, Sun F, Park KK, et al: SOCS3
deletion promotes optic nerve regeneration in vivo. Neuron.
64:617–623. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Sun F, Park KK, Belin S, et al: Sustained
axon regeneration induced by co-deletion of PTEN and SOCS3. Nature.
480:372–375. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Garza JC, Guo M, Zhang W and Lu XY: Leptin
increases adult hippocampal neurogenesis in vivo and in vitro. J
Biol Chem. 283:18238–18247. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Kim YH, Chung JI, Woo HG, et al:
Differential regulation of proliferation and differentiation in
neural precursor cells by the Jak pathway. Stem Cells.
28:1816–1828. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Watanabe S, Itoh T and Arai K: Roles of
JAK kinase in human GM-CSF receptor signals. Leukemia. 11 (Suppl
3):76–78. 1997.PubMed/NCBI
|
|
63
|
Mui AL, Wakao H, Kinoshita T, Kitamura T
and Miyajima A: Suppression of interleukin-3-induced gene
expression by a C-terminal truncated Stat5: role of Stat5 in
proliferation. EMBO J. 15:2425–2433. 1996.PubMed/NCBI
|
|
64
|
Gu F, Hata R, Ma YJ, et al: Suppression of
Stat3 promotes neurogenesis in cultured neural stem cells. J
Neurosci Res. 81:163–171. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Kernie SG, Erwin TM and Parada LF: Brain
remodeling due to neuronal and astrocytic proliferation after
controlled cortical injury in mice. J Neurosci Res. 66:317–326.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
David S and Lacroix S: Molecular
approaches to spinal cord repair. Annu Rev Neurosci. 26:411–440.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Bartholdi D and Schwab ME: Expression of
pro-inflammatory cytokine and chemokine mRNA upon experimental
spinal cord injury in mouse: an in situ hybridization study. Eur J
Neurosci. 9:1422–1438. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Hayashi M, Ueyama T, Nemoto K, Tamaki T
and Senba E: Sequential mRNA expression for immediate early genes,
cytokines, and neurotrophins in spinal cord injury. J Neurotrauma.
17:203–218. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Pan JZ, Ni L, Sodhi A, Aguanno A, Young W
and Hart RP: Cytokine activity contributes to induction of
inflammatory cytokine mRNAs in spinal cord following contusion. J
Neurosci Res. 68:315–322. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Streit WJ, Semple-Rowland SL, Hurley SD,
Miller RC, Popovich PG and Stokes BT: Cytokine mRNA profiles in
contused spinal cord and axotomized facial nucleus suggest a
beneficial role for inflammation and gliosis. Exp Neurol.
152:74–87. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Herrmann JE, Imura T, Song B, et al: STAT3
is a critical regulator of astrogliosis and scar formation after
spinal cord injury. J Neurosci. 28:7231–7243. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Satriotomo I, Bowen KK and Vemuganti R:
JAK2 and STAT3 activation contributes to neuronal damage following
transient focal cerebral ischemia. J Neurochem. 98:1353–1368. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Kang W and Hebert JM: Signaling pathways
in reactive astrocytes, a genetic perspective. Mol Neurobiol.
43:147–154. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Okada S, Nakamura M, Mikami Y, et al:
Blockade of interleukin-6 receptor suppresses reactive astrogliosis
and ameliorates functional recovery in experimental spinal cord
injury. J Neurosci Res. 76:265–276. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Rolls A, Shechter R and Schwartz M: The
bright side of the glial scar in CNS repair. Nat Rev Neurosci.
10:235–241. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Yuan YM and He C: The glial scar in spinal
cord injury and repair. Neurosci Bull. 29:421–435. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Karimi-Abdolrezaee S and Billakanti R:
Reactive astrogliosis after spinal cord injury-beneficial and
detrimental effects. Mol Neurobiol. 46:251–264. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Silver J and Miller JH: Regeneration
beyond the glial scar. Nat Rev Neurosci. 5:146–156. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Faulkner JR, Herrmann JE, Woo MJ, Tansey
KE, Doan NB and Sofroniew MV: Reactive astrocytes protect tissue
and preserve function after spinal cord injury. J Neurosci.
24:2143–2155. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Okada S, Nakamura M, Katoh H, et al:
Conditional ablation of Stat3 or Socs3 discloses a dual role for
reactive astrocytes after spinal cord injury. Nat Med. 12:829–834.
2006. View
Article : Google Scholar : PubMed/NCBI
|
|
81
|
Cho N, Nguyen DH, Satkunendrarajah K,
Branch DR and Fehlings MG: Evaluating the role of IL-11, a novel
cytokine in the IL-6 family, in a mouse model of spinal cord
injury. J Neuroinflammation. 9:1342012. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Leung YK, Pankhurst M, Dunlop SA, et al:
Metallothionein induces a regenerative reactive astrocyte phenotype
via JAK/STAT and RhoA signalling pathways. Exp Neurol. 221:98–106.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Hamby ME and Sofroniew MV: Reactive
astrocytes as therapeutic targets for CNS disorders.
Neurotherapeutics. 7:494–506. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Lieberman AP, Pitha PM, Shin HS and Shin
ML: Production of tumor necrosis factor and other cytokines by
astrocytes stimulated with lipopolysaccharide or a neurotropic
virus. Proc Natl Acad Sci USA. 86:6348–6352. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Sofroniew MV: Molecular dissection of
reactive astrogliosis and glial scar formation. Trends Neurosci.
32:638–647. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Chu T, Zhou H, Li F, Wang T, Lu L and Feng
S: Astrocyte transplantation for spinal cord injury: current status
and perspective. Brain Res Bull. 107C:18–30. 2014. View Article : Google Scholar
|
|
87
|
Hamby ME, Hewett JA and Hewett SJ:
TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2
and nitric oxide synthase-2 gene expression in a
stimulus-independent manner. Prostaglandins Other Lipid Mediat.
85:115–124. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Hamby ME, Gragnolati AR, Hewett SJ and
Hewett JA: TGF beta 1 and TNF alpha potentiate nitric oxide
production in astrocyte cultures by recruiting distinct
subpopulations of cells to express NOS-2. Neurochem Int.
52:962–971. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Hamby ME, Hewett JA and Hewett SJ:
TGF-beta1 potentiates astrocytic nitric oxide production by
expanding the population of astrocytes that express NOS-2. Glia.
54:566–577. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Hewett SJ: Interferon-gamma reduces
cyclooxygenase-2-mediated prostaglandin E2 production from primary
mouse astrocytes independent of nitric oxide formation. J
Neuroimmunol. 94:134–143. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Minghetti L, Polazzi E, Nicolini A and
Levi G: Opposite regulation of prostaglandin E2 synthesis by
transforming growth factor-beta1 and interleukin 10 in activated
microglial cultures. J Neuroimmunol. 82:31–39. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Hewett SJ, Corbett JA, McDaniel ML and
Choi DW: Interferon-gamma and interleukin-1 beta induce nitric
oxide formation from primary mouse astrocytes. Neurosci Lett.
164:229–232. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Zhang Y, Taveggia C, Melendez-Vasquez C,
et al: Interleukin-11 potentiates oligodendrocyte survival and
maturation, and myelin formation. J Neurosci. 26:12174–12185. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Mena MA and Garcia de Yebenes J: Glial
cells as players in parkinsonism: the ‘good,’ the ‘bad,’ and the
‘mysterious’ glia. Neuroscientist. 14:544–560. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Villoslada P and Genain CP: Role of nerve
growth factor and other trophic factors in brain inflammation. Prog
Brain Res. 146:403–414. 2004.PubMed/NCBI
|
|
96
|
Krieglstein K, Reuss B, Maysinger D and
Unsicker K: Short communication: transforming growth factor-beta
mediates the neurotrophic effect of fibroblast growth factor-2 on
midbrain dopaminergic neurons. Eur J Neurosci. 10:2746–2750. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Ridet JL, Malhotra SK, Privat A and Gage
FH: Reactive astrocytes: cellular and molecular cues to biological
function. Trends Neurosci. 20:570–577. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Saad B, Constam DB, Ortmann R, Moos M,
Fontana A and Schachner M: Astrocyte-derived TGF-beta 2 and NGF
differentially regulate neural recognition molecule expression by
cultured astrocytes. J Cell Biol. 115:473–484. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
White RE and Jakeman LB: Don't fence me
in: harnessing the beneficial roles of astrocytes for spinal cord
repair. Restor Neurol Neurosci. 26:197–214. 2008.PubMed/NCBI
|
|
100
|
Cattaneo E, Conti L and De-Fraja C:
Signalling through the JAK-STAT pathway in the developing brain.
Trends Neurosci. 22:365–369. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Heinrich PC, Behrmann I, Muller-Newen G,
Schaper F and Graeve L: Interleukin-6-type cytokine signalling
through the gp130/Jak/STAT pathway. Biochem J. 334:297–314.
1998.PubMed/NCBI
|
|
102
|
Hirano T, Nakajima K and Hibi M: Signaling
mechanisms through gp130: a model of the cytokine system. Cytokine
Growth Factor Rev. 8:241–252. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Taga T: Gp130, a shared signal transducing
receptor component for hematopoietic and neuropoietic cytokines. J
Neurochem. 67:1–10. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Taga T and Kishimoto T: Gp130 and the
interleukin-6 family of cytokines. Annu Rev Immunol. 15:797–819.
1997. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Yamauchi K, Osuka K, Takayasu M, et al:
Activation of JAK/STAT signalling in neurons following spinal cord
injury in mice. J Neurochem. 96:1060–1070. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Ikeda K, Kinoshita M, Tagaya N, et al:
Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor
delays progression of wobbler mouse motor neuron disease. Brain
Res. 726:91–97. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Pavelko KD, Howe CL, Drescher KM, et al:
Interleukin-6 protects anterior horn neurons from lethal
virus-induced injury. J Neurosci. 23:481–492. 2003.PubMed/NCBI
|
|
108
|
Zhong J, Dietzel ID, Wahle P, Kopf M and
Heumann R: Sensory impairments and delayed regeneration of sensory
axons in interleukin-6-deficient mice. J Neurosci. 19:4305–4313.
1999.PubMed/NCBI
|
|
109
|
Park JS, Lee J, Lim MA, et al: JAK2-STAT3
blockade by AG490 suppresses autoimmune arthritis in mice via
reciprocal regulation of regulatory T cells and Th17 cells. J
Immunol. 192:4417–4424. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Kerr BJ and Patterson PH: Potent
pro-inflammatory actions of leukemia inhibitory factor in the
spinal cord of the adult mouse. Exp Neurol. 188:391–407. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Barres BA, Hart IK, Coles HS, et al: Cell
death and control of cell survival in the oligodendrocyte lineage.
Cell. 70:31–46. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Barres BA, Schmid R, Sendnter M and Raff
MC: Multiple extracellular signals are required for long-term
oligodendrocyte survival. Development. 118:283–295. 1993.PubMed/NCBI
|
|
113
|
D'Souza SD, Alinauskas KA and Antel JP:
Ciliary neurotrophic factor selectively protects human
oligodendrocytes from tumor necrosis factor-mediated injury. J
Neurosci Res. 43:289–298. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Kahn MA and De Vellis J: Regulation of an
oligodendrocyte progenitor cell line by the interleukin-6 family of
cytokines. Glia. 12:87–98. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Louis JC, Magal E, Takayama S and Varon S:
CNTF protection of oligodendrocytes against natural and tumor
necrosis factor-induced death. Science. 259:689–692. 1993.
View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Noble M, Murray K, Stroobant P, Waterfield
MD and Riddle P: Platelet-derived growth factor promotes division
and motility and inhibits premature differentiation of the
oligodendrocyte/type-2 astrocyte progenitor cell. Nature.
333:560–562. 1988. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Raff MC, Lillien LE, Richardson WD, Burne
JF and Noble MD: Platelet-derived growth factor from astrocytes
drives the clock that times oligodendrocyte development in culture.
Nature. 333:562–565. 1988. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Richardson WD, Pringle N, Mosley MJ,
Westermark B and Dubois-Dalcq M: A role for platelet-derived growth
factor in normal gliogenesis in the central nervous system. Cell.
53:309–319. 1988. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Oyesiku NM, Wilcox JN and Wigston DJ:
Changes in expression of ciliary neurotrophic factor (CNTF) and
CNTF-receptor alpha after spinal cord injury. J Neurobiol.
32:251–261. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Lee MY, Kim CJ, Shin SL, Moon SH and Chun
MH: Increased ciliary neurotrophic factor expression in reactive
astrocytes following spinal cord injury in the rat. Neurosci Lett.
255:79–82. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Dell'Albani P, Kahn MA, Cole R, Condorelli
DF, Giuffrida-Stella AM and de Vellis J: Oligodendroglial survival
factors, PDGF-AA and CNTF, activate similar JAK/STAT signaling
pathways. J Neurosci Res. 54:191–205. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Dedoni S, Olianas MC and Onali P:
Interferon-beta induces apoptosis in human SH-SY5Y neuroblastoma
cells through activation of JAK-STAT signaling and down-regulation
of PI3K/Akt pathway. Journal of neurochemistry. 115:1421–1433.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Schindler C, Levy DE and Decker T:
JAK-STAT signaling: from interferons to cytokines. J Biol Chem.
282:20059–20063. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Suzuki S, Tanaka K and Suzuki N:
Ambivalent aspects of interleukin-6 in cerebral ischemia:
inflammatory versus neurotrophic aspects. J Cereb Blood Flow Metab.
29:464–479. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Suzuki S, Yamashita T, Tanaka K, et al:
Activation of cytokine signaling through leukemia inhibitory factor
receptor (LIFR)/gp130 attenuates ischemic brain injury in rats. J
Cereb Blood Flow Metab. 25:685–693. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Yamashita T, Sawamoto K, Suzuki S, et al:
Blockade of interleukin-6 signaling aggravates ischemic cerebral
damage in mice: possible involvement of Stat3 activation in the
protection of neurons. J Neurochem. 94:459–468. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Battle TE and Frank DA: The role of STATs
in apoptosis. Curr Mol Med. 2:381–392. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Ahn YH, Lee G and Kang SK: Molecular
insights of the injured lesions of rat spinal cords: inflammation,
apoptosis, and cell survival. Biochem Biophys Res Commun.
348:560–570. 2006. View Article : Google Scholar : PubMed/NCBI
|
