Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant

Wang,Jiayi; Xiao,Yongmei; Lin,Kai; Song,Feifei; Ge,Ting; Zhang,Ting

doi:10.3892/br.2014.403

March-2015 Volume 3 Issue 2

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March-2015 Volume 3 Issue 2

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Article

Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant

Authors:
- Jiayi Wang
- Yongmei Xiao
- Kai Lin
- Feifei Song
- Ting Ge
- Ting Zhang
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
Pages: 173-175
|
Published online on: December 15, 2014

https://doi.org/10.3892/br.2014.403
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Abstract

Fecal microbiota transplantation (FMT) is a procedure used to restore the intestinal microbiota of a diseased individual using indigenous intestinal microorganisms from a healthy donor. The current case report presents the first case of a 13‑month‑old male with severe pseudomembranous enteritis (PME) treated with FMT. The infant was admitted to Shanghai Children's Hospital with a 2‑month history of diarrhea, and a 1.5‑month history of retractable edema, hypoalbuminemia, electrolyte disturbance and malnutrition. Besides necessary nutritional support, the patient was treated twice with oral metronidazole combined with or without vancomycin. Diarrhea was partially remitted. However, the infant had bloody or dark‑green feces, and a distended abdomen. On day 96 from the initiation of the disease, a single FMT via a nasal jejuna feeding tube was performed. From day 2 until 4 months post‑FMT, the patient presented with no diarrhea, normal feces and a satisfactory weight. To the best of our knowledge, this is the first pediatric PME treated with FMT. The current data show that FMT is an efficient choice for recurrent clostridium difficile infection and PME in adults and a few pediatric cases. Due to a lack of safety and effectiveness data, treatment should be cautiously applied in the pediatric population.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant

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