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Review

Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review)

  • Authors:
    • Hong Li
    • Chen Chen
    • Shiyi Chen
  • View Affiliations / Copyright

    Affiliations: Department of Sports Medicine, Huashan Hospital, Shanghai 200040, P.R. China, Department of Orthopaedics, Zhongshan Hospital, Shanghai 200032, P.R. China
  • Pages: 147-151
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    Published online on: December 17, 2014
       https://doi.org/10.3892/br.2014.404
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Abstract

As a common injury, anterior cruciate ligament (ACL) injury is unable to heal itself naturally, which possibly increases knee instability, accelerates the risk of joint degeneration and leads to knee osteoarthritis (OA) in the ACL‑injured knee. Thus, ACL reconstruction using an autograft or allograft tendon is proposed to maintain the biomechanical stability of the knee joint. However, previous studies demonstrate that surgical management of ACL reconstruction failed to abrogate the development of OA completely, indicating that biochemical disturbance is responsible for the osteoarthritic changes observed following ACL injury. Inflammatory mediators are elevated subsequent to ACL injury or rupture, inducing matrix metalloproteinase production, proteoglycan degradation, collagen destruction, chondrocyte necrosis and lubricin loss. These potential biochemical mediators may aid in the development of effective biological management to reduce the onset of future posttraumatic OA. Furthermore, during the degenerative process of cartilage, there are a number of cartilage‑specific biomarkers, which play a critical step in the loss of structural and functional integrity of cartilage. The present review illustrates several specific biomarkers in the ACL‑injured knee joint, which may provide effective diagnostic and prognostic tools for investigating cartilage degenerative progression and future posttraumatic OA of ACL‑injured patients.
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1 

Spindler KP and Wright RW: Clinical practice. Anterior cruciate ligament tear. N Engl J Med. 359:2135–2142. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Frobell RB, Roos EM, Roos HP, Ranstam J and Lohmander LS: A randomized trial of treatment for acute anterior cruciate ligament tears. N Engl J Med. 363:331–342. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Brophy RH, Zeltser D, Wright RW and Flanigan D: Anterior cruciate ligament reconstruction and concomitant articular cartilage injury: incidence and treatment. Arthroscopy. 26:112–120. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Lohmander LS, Ostenberg A, Englund M and Roos H: High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum. 50:3145–3152. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Nelson F, Billinghurst RC, Pidoux I, et al: Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament. Osteoarthritis Cartilage. 14:114–119. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Li G, Moses JM, Papannagari R, Pathare NP, De Frate LE and Gill TJ: Anterior cruciate ligament deficiency alters the in vivo motion of the tibiofemoral cartilage contact points in both the anteroposterior and mediolateral directions. J Bone Joint Surg Am. 88:1826–1834. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Van de Velde SK, Bingham JT, Hosseini A, et al: Increased tibiofemoral cartilage contact deformation in patients with anterior cruciate ligament deficiency. Arthritis Rheum. 60:3693–3702. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Church S and Keating JF: Reconstruction of the anterior cruciate ligament: timing of surgery and the incidence of meniscal tears and degenerative change. J Bone Joint Surg Br. 87:1639–1642. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Granan LP, Bahr R, Lie SA and Engebretsen L: Timing of anterior cruciate ligament reconstructive surgery and risk of cartilage lesions and meniscal tears: a cohort study based on the Norwegian National Knee Ligament Registry. Am J Sports Med. 37:955–961. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Fajardo M and Di Cesare PE: Disease-modifying therapies for osteoarthritis: current status. Drugs Aging. 22:141–161. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Li H, Hosseini A, Li JS, Gill TJ IV and Li G: Quantitative magnetic resonance imaging (MRI) morphological analysis of knee cartilage in healthy and anterior cruciate ligament-injured knees. Knee Surg Sports Traumatol Arthrosc. 20:1496–1502. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Friel NA and Chu CR: The role of ACL injury in the development of posttraumatic knee osteoarthritis. Clin Sports Med. 32:1–12. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Ferretti A, Conteduca F, De Carli A, Fontana M and Mariani PP: Osteoarthritis of the knee after ACL reconstruction. Int Orthop. 15:367–371. 1991. View Article : Google Scholar : PubMed/NCBI

14 

Daniel DM, Stone ML, Dobson BE, Fithian DC, Rossman DJ and Kaufman KR: Fate of the ACL-injured patient. A prospective outcome study. Am J Sports Med. 22:632–644. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Li H, Tao H, Hua Y, Chen J, Li Y and Chen S: Quantitative magnetic resonance imaging assessment of cartilage status: a comparison between young men with and without anterior cruciate ligament reconstruction. Arthroscopy. 29:2012–2019. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Oiestad BE, Holm I, Engebretsen L and Risberg MA: The association between radiographic knee osteoarthritis and knee symptoms, function and quality of life 10–15 years after anterior cruciate ligament reconstruction. Br J Sports Med. 45:583–588. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Kraus VB, Birmingham J, Stabler TV, et al: Effects of intraarticular I11-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthritis Cartilage. 20:271–278. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Wei L, Fleming BC, Sun X, et al: Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model. J Orthop Res. 28:900–906. 2010.PubMed/NCBI

19 

Marks PH and Donaldson ML: Inflammatory cytokine profiles associated with chondral damage in the anterior cruciate ligament-deficient knee. Arthroscopy. 21:1342–1347. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Aigner T, Soeder S and Haag J: IL-1beta and BMPs - interactive players of cartilage matrix degradation and regeneration. Eur Cell Mater. 12:49–56. 2006.PubMed/NCBI

21 

Turner NA, Warburton P, O'Regan DJ, Ball SG and Porter KE: Modulatory effect of interleukin-1alpha on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p 38 MAP kinase. Matrix Biol. 29:613–620. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Xue R, Yang L, Tang Z, et al: The profile of MMP and TIMP in injured rat ACL. Mol Cell Biomech. 7:115–124. 2010.PubMed/NCBI

23 

Chen WP, Tang JL, Bao JP, et al: Effects of diallyl sulphide in chondrocyte and cartilage in experimental osteoarthritis in rabbit. Phytother Res. 25:351–356. 2011.PubMed/NCBI

24 

Tang Z, Yang L, Zhang J, et al: Coordinated expression of MMPs and TIMPs in rat knee intra-articular tissues after ACL injury. Connect Tissue Res. 50:315–322. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Ra HJ and Parks WC: Control of matrix metalloproteinase catalytic activity. Matrix Biol. 26:587–596. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Lin PM, Chen CT and Torzilli PA: Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage. Osteoarthritis Cartilage. 12:485–496. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Ni GX, Zhan LQ, Gao MQ, Lei L, Zhou YZ and Pan YX: Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Arthritis Res Ther. 13:R1922011. View Article : Google Scholar : PubMed/NCBI

28 

Catterall JB, Stabler TV, Flannery CR and Kraus VB: Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). Arthritis Res Ther. 12:R2292010. View Article : Google Scholar : PubMed/NCBI

29 

Hattori S, Sakane M, Mutsuzaki H, Tanaka J, Ochiai N and Nakajima H: Chondrocyte apoptosis and decrease of glycosaminoglycan in cranial cruciate ligament insertion after resection in rabbits. J Vet Med Sci. 69:253–258. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Sakane M, Mutsuzaki H, Hattori S, Nakajima H and Ochiai N: Time dependence of changes of two cartilage layers in anterior cruciate ligament insertion after resection on chondrocyte apoptosis and decrease in glycosaminoglycan. Sports Med Arthrosc Rehabil Ther Technol. 1:272009. View Article : Google Scholar : PubMed/NCBI

31 

Connelly JT, Wilson CG and Levenston ME: Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs. Osteoarthritis Cartilage. 16:1092–1100. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Little CB, Hughes CE, Curtis CL, et al: Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix Biol. 21:271–288. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Troeberg L and Nagase H: Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta. 1824:133–145. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Caterson B, Flannery CR, Hughes CE and Little CB: Mechanisms involved in cartilage proteoglycan catabolism. Matrix Biol. 19:333–344. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Sondergaard BC, Schultz N, Madsen SH, Bay-Jensen AC, Kassem M and Karsdal MA: MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation - divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage. 18:279–288. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Lorenz H, Wenz W, Ivancic M, Steck E and Richter W: Early and stable upregulation of collagen type II, collagen type I and YK140 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading. Arthritis Res Ther. 7:R156–R165. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Pujol JP, Chadjichristos C, Legendre F, et al: Interleukin-1 and transforming growth factor-beta 1 as crucial factors in osteoarthritic cartilage metabolism. Connect Tissue Res. 49:293–297. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Chadjichristos C, Ghayor C, Kypriotou M, et al: Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes. J Biol Chem. 278:39762–39772. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Porée B, Kypriotou M, Chadjichristos C, et al: Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1. Sp3 ratio and of the binding activity of both factors to the CO12A1 promoter. J Biol Chem. 283:4850–4865. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Mutsuzaki H, Sakane M, Ikeda K, et al: Histological changes and apoptosis of cartilage layer in human anterior cruciate ligament tibial insertion after rupture. Knee Surg Sports Traumatol Arthrosc. 15:602–609. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Mutsuzaki H, Sakane M, Honda K, Ikeda K, Hattori S and Ochiai N: Cell death and cell proliferation in cartilage layers in human anterior cruciate ligament tibial insertions after rupture. Connect Tissue Res. 51:282–288. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Nishimuta JF and Levenston ME: Response of cartilage and meniscus tissue explants to in vitro compressive overload. Osteoarthritis Cartilage. 20:422–429. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Xu L, Hayashi D, Roemer FW, Felson DT and Guermazi A: Magnetic resonance imaging of subchondral bone marrow lesions in association with osteoarthritis. Semin Arthritis Rheum. 42:105–118. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Lewis JL, Deloria LB, Oyen-Tiesma M, Thompson RC Jr, Ericson M and Oegema TR Jr: Cell death after cartilage impact occurs around matrix cracks. J Orthop Res. 21:881–887. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Frobell RB: Change in cartilage thickness, posttraumatic bone marrow lesions, and joint fluid volumes after acute ACL disruption: a two-year prospective MRI study of sixty-one subjects. J Bone Joint Surg Am. 93:1096–1103. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Nakamae A, Engebretsen L, Bahr R, Krosshaug T and Ochi M: Natural history of bone bruises after acute knee injury: clinical outcome and histopathological findings. Knee Surg Sports Traumatol Arthrosc. 14:1252–1258. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Lahm A, Uhl M, Erggelet C, Haberstroh J and Mrosek E: Articular cartilage degeneration after acute subchondral bone damage: an experimental study in dogs with histopathological grading. Acta Orthop Scand. 75:762–767. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Lahm A, Kreuz PC, Oberst M, Haberstroh J, Uhl M and Maier D: Subchondral and trabecular bone remodeling in canine experimental osteoarthritis. Arch Orthop Trauma Surg. 126:582–587. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Beekhuizen M, van Osch GJ, Bot AG, et al: Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair. Eur Cell Mater. 26:80–90. 2013.PubMed/NCBI

50 

Tsuchida AI, Beekhuizen M, Rutgers M, et al: Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther. 14:R2622012. View Article : Google Scholar : PubMed/NCBI

51 

Sharif M, Kirwan J, Charni N, Sandell LJ, Whittles C and Garnero P: A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis - association with disease progression. Rheumatology (Oxford). 46:938–943. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Lohmander LS, Atley LM, Pietka TA and Eyre DR: The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum. 48:3130–3139. 2003. View Article : Google Scholar : PubMed/NCBI

53 

Duclos ME, Roualdes O, Cararo R, Rousseau JC, Roger T and Hartmann DJ: Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study. Osteoarthritis Cartilage. 18:1467–1476. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Freeston JE, Garnero P, Wakefield RJ, Hensor EM, Conaghan PG and Emery P: Urinary type II collagen C-terminal peptide is associated with synovitis and predicts structural bone loss in very early inflammatory arthritis. Ann Rheum Dis. 70:331–333. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Ikegawa S, Sano M, Koshizuka Y and Nakamura Y: Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenet Cell Genet. 90:291–297. 2000. View Article : Google Scholar : PubMed/NCBI

56 

Jay GD, Tantravahi U, Britt DE, Barrach HJ and Cha CJ: Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25. J Orthop Res. 19:677–687. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Liu YJ, Lu SH, Xu B, et al: Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood. 103:4449–4456. 2004. View Article : Google Scholar : PubMed/NCBI

58 

Coles JM, Zhang L, Blum JJ, et al: Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum. 62:1666–1674. 2010. View Article : Google Scholar : PubMed/NCBI

59 

Schmidt TA, Gastelum NS, Nguyen QT, Schumacher BL and Sah RL: Boundary lubrication of articular cartilage: role of synovial fluid constituents. Arthritis Rheum. 56:882–891. 2007. View Article : Google Scholar : PubMed/NCBI

60 

Rhee DK, Marcelino J, Baker M, et al: The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 115:622–631. 2005. View Article : Google Scholar : PubMed/NCBI

61 

Elsaid KA, Machan JT, Waller K, Fleming BC and Jay GD: The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model. Arthritis Rheum. 60:2997–3006. 2009. View Article : Google Scholar : PubMed/NCBI

62 

Nugent GE, Aneloski NM, Schmidt TA, Schumacher BL, Voegtline MS and Sah RL: Dynamic shear stimulation of bovine cartilage biosynthesis of proteoglycan 4. Arthritis Rheum. 54:1888–1896. 2006. View Article : Google Scholar : PubMed/NCBI

63 

Nugent-Derfus GE, Takara T, O'Neill JK, et al: Continuous passive motion applied to whole joints stimulates chondrocyte biosynthesis of PRG4. Osteoarthritis Cartilage. 15:566–574. 2007. View Article : Google Scholar : PubMed/NCBI

64 

Matyas JR, Atley L, Ionescu M, Eyre DR and Poole AR: Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis. Arthritis Rheum. 50:543–552. 2004. View Article : Google Scholar : PubMed/NCBI

65 

Jones AR, Chen S, Chai DH, et al: Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum. 60:133–142. 2009. View Article : Google Scholar : PubMed/NCBI

66 

Englert C, McGowan KB, Klein TJ, Giurea A, Schumacher BL and Sah RL: Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. Arthritis Rheum. 52:1091–1099. 2005. View Article : Google Scholar : PubMed/NCBI

67 

Schmidt TA, Gastelum NS, Han EH, Nugent-Derfus GE, Schumacher BL and Sah RL: Differential regulation of proteoglycan 4 metabolism in cartilage by IL-1alpha, IGF-I, and TGF-beta1. Osteoarthritis Cartilage. 16:90–97. 2008. View Article : Google Scholar : PubMed/NCBI

68 

Neu CP, Khalafi A, Komvopoulos K, Schmid TM and Reddi AH: Mechanotransduction of bovine articular cartilage superficial zone protein by transforming growth factor beta signaling. Arthritis Rheum. 56:3706–3714. 2007. View Article : Google Scholar : PubMed/NCBI

69 

Gleghorn JP, Jones AR, Flannery CR and Bonassar LJ: Alteration of articular cartilage frictional properties by transforming growth factor beta, interleukin-1beta, and oncostatin M. Arthritis Rheum. 60:440–449. 2009. View Article : Google Scholar : PubMed/NCBI

70 

Elsaid KA, Fleming BC, Oksendahl HL, et al: Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum. 58:1707–1715. 2008. View Article : Google Scholar : PubMed/NCBI

71 

Elsaid KA, Jay GD, Warman ML, Rhee DK and Chichester CO: Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum. 52:1746–1755. 2005. View Article : Google Scholar : PubMed/NCBI

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Li H, Chen C and Chen S: Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review). Biomed Rep 3: 147-151, 2015.
APA
Li, H., Chen, C., & Chen, S. (2015). Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review). Biomedical Reports, 3, 147-151. https://doi.org/10.3892/br.2014.404
MLA
Li, H., Chen, C., Chen, S."Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review)". Biomedical Reports 3.2 (2015): 147-151.
Chicago
Li, H., Chen, C., Chen, S."Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review)". Biomedical Reports 3, no. 2 (2015): 147-151. https://doi.org/10.3892/br.2014.404
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Spandidos Publications style
Li H, Chen C and Chen S: Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review). Biomed Rep 3: 147-151, 2015.
APA
Li, H., Chen, C., & Chen, S. (2015). Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review). Biomedical Reports, 3, 147-151. https://doi.org/10.3892/br.2014.404
MLA
Li, H., Chen, C., Chen, S."Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review)". Biomedical Reports 3.2 (2015): 147-151.
Chicago
Li, H., Chen, C., Chen, S."Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers (Review)". Biomedical Reports 3, no. 2 (2015): 147-151. https://doi.org/10.3892/br.2014.404
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