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Article

Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

  • Authors:
    • Malgorzata Szczepańska
    • Adrianna Mostowska
    • Przemyslaw Wirstlein
    • Jana Skrzypczak
    • Paweł P. Jagodziński
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, Poznań 60‑781, Poland, Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60‑781, Poland
  • Pages: 220-224
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    Published online on: December 19, 2014
       https://doi.org/10.3892/br.2014.409
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Abstract

There are inconsistent data on the contribution of vascular endothelial growth factor (VEGF) ‑460 C/T (rs833061), +405 G/C (rs2010963) and +936 C/T (rs3025039) single‑nucleotide polymorphisms (SNPs) to endometriosis in different ethnicities. Therefore, using high‑resolution melting curve analysis, the present study examined the distribution of these SNPs in females with endometriosis‑related infertility and a control group. None of the three VEGF SNPs were associated with endometriosis‑related infertility in the dominant and recessive models. The lowest P‑values of the trend were observed for the VEGF +936 C/T (rs3025039) SNP in endometriosis‑related infertility (Ptrend=0.149). Similarly, haplotype analyses of VEGF SNPs did not demonstrate any SNP combination as a risk for endometriosis‑related infertility, and the lowest overall P‑values, P=0.141 and Pcorr=0.395, were observed for a haplotype (TGT) of the above SNPs. Taken together, these results did not demonstrate the contribution of VEGF C/T, +405 G/C and +936 C/T SNPs to endometriosis‑related infertility.
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Copy and paste a formatted citation
Spandidos Publications style
Szczepańska M, Mostowska A, Wirstlein P, Skrzypczak J and Jagodziński PP: Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis. Biomed Rep 3: 220-224, 2015.
APA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., & Jagodziński, P.P. (2015). Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis. Biomedical Reports, 3, 220-224. https://doi.org/10.3892/br.2014.409
MLA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis". Biomedical Reports 3.2 (2015): 220-224.
Chicago
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis". Biomedical Reports 3, no. 2 (2015): 220-224. https://doi.org/10.3892/br.2014.409
Copy and paste a formatted citation
x
Spandidos Publications style
Szczepańska M, Mostowska A, Wirstlein P, Skrzypczak J and Jagodziński PP: Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis. Biomed Rep 3: 220-224, 2015.
APA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., & Jagodziński, P.P. (2015). Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis. Biomedical Reports, 3, 220-224. https://doi.org/10.3892/br.2014.409
MLA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis". Biomedical Reports 3.2 (2015): 220-224.
Chicago
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis". Biomedical Reports 3, no. 2 (2015): 220-224. https://doi.org/10.3892/br.2014.409
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