Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
March-2015 Volume 3 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 3 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis

  • Authors:
    • Ning Zhu
    • Yuanyuan Zhang
    • Yi Gong
    • Jian He
    • Xiaodong Chen
  • View Affiliations / Copyright

    Affiliations: Respiratory Department, Huashan Hospital, Affiliated to Fudan University, Shanghai 200040, P.R. China
  • Pages: 235-241
    |
    Published online on: January 9, 2015
       https://doi.org/10.3892/br.2015.417
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The association between metformin and the lung cancer risk of patients with type 2 diabetes mellitus (T2DM) remains controversial. Therefore, the present meta‑analysis on epidemiological studies was performed to explore this issue. A comprehensive literature search was conducted for all the potential studies addressing metformin use and lung cancer risk by utilizing Pubmed, CBM and ISI Web of Science using the Mesh terms: ‘Metformin,’ or ‘biguanides’ and ‘lung cancer,’ or ‘neoplasms’. The reference lists were also inspected. Eight observational studies, including 17,997 lung cancer patients, were eventually selected, which contained seven case‑control and one cohort study. Compared to other antidiabetic agents, metformin was significantly associated with the 16% reduction of lung cancer risk in type 2 diabetic patients [relative risk (RR)=0.84; 95% confidence interval (95% CI), 0.73‑0.97]. In the sensitivity analysis by separately excluding the study with a high weight or lower quality, the results did not materially change. Subsequently, subgroup analysis was performed on the type of study design, unadjusted or adjusted hazard ratio, quality of enrolled studies, duration of treatment, country and control drugs. The magnitude of lung cancer risk reduction was strengthened when compared to sulfonylureas (RR=0.79; 95% CI, 0.83‑0.9), without significant heterogeneity (Q‑value=2.98, P=0.085). In conclusion, the present analysis supported that the use of metformin significantly decreased the risk of lung cancer among patients with T2DM. However, further studies are required to confirm these findings.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Yerrabothala S, Shaaban H, Capo G, Maroules M and Debari VA: The impact of diabetes mellitus on breast cancer outcomes: a single center retrospective study. Pathol Oncol Res. 20:209–214. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Lee JY, Jeon I, Lee JM, Yoon JM and Park SM: Diabetes mellitus as an independent risk factor for lung cancer: a meta-analysis of observational studies. Eur J Cancer. 49:2411–2423. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Wang JY, Chao TT, Lai CC, et al: Risk of colorectal cancer in type 2 diabetic patients: a population-based cohort study. Jpn J Clin Oncol. 43:258–263. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Gupta SP, Mittal A, Jha DK, Pandeya DR and Sathian B: Diabetes mellitus and renal cell carcinoma - a hospital based study from Kathmandu Valley. Asian Pac J Cancer Prev. 13:4963–4965. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Onitilo AA, Stankowski RV, Berg RL, et al: Type 2 diabetes mellitus, glycemic control, and cancer risk. Eur J Cancer Prev. 23:134–140. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Franciosi M, Lucisano G, Lapice E, Strippoli GF, Pellegrini F and Nicolucci A: Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS One. 8:e715832013. View Article : Google Scholar : PubMed/NCBI

7 

Lin CC, Yeh HH, Huang WL, et al: Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway. Am J Respir Cell Mol Biol. 49:241–250. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Han D, Li SJ, Zhu YT, Liu L and Li MX: LKB1/AMPK/mTOR signaling pathway in non-small-cell lung cancer. Asian Pac J Cancer Prev. 14:4033–4039. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Quinn BJ, Dallos M, Kitagawa H, et al: Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling. Cancer Prev Res (Phila). 6:801–810. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Kourelis TV and Siegel RD: Metformin and cancer: new applications for an old drug. Med Oncol. 29:1314–1327. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Kato K, Gong J, Iwama H, et al: The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo. Mol Cancer Ther. 11:549–560. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Storozhuk Y, Hopmans SN, Sanli T, et al: Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer. 108:2021–2032. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Kumar S, Meuter A, Thapa P, et al: Metformin intake is associated with better survival in ovarian cancer: a case-control study. Cancer. 119:555–562. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Ferla R, Haspinger E and Surmacz E: Metformin inhibits leptin-induced growth and migration of glioblastoma cells. Oncol Lett. 4:1077–1081. 2012.PubMed/NCBI

15 

Kobayashi M, Kato K, Iwama H, et al: Antitumor effect of metformin in esophageal cancer: In vitro study. Int J Oncol. 42:517–524. 2013.PubMed/NCBI

16 

Noto H, Goto A, Tsujimoto T and Noda M: Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis. PLoS One. 7:e334112012. View Article : Google Scholar : PubMed/NCBI

17 

Lee MS, Hsu CC, Wahlqvist ML, Tsai HN, Chang YH and Huang YC: Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer. 11:202011. View Article : Google Scholar : PubMed/NCBI

18 

Mazzone PJ, Rai H, Beukemann M, Xu M, Jain A and Sasidhar M: The effect of metformin and thiazolidinedione use on lung cancer in diabetics. BMC Cancer. 12:4102012. View Article : Google Scholar : PubMed/NCBI

19 

Ruiter R, Visser LE, van Herk-Sukel MP, et al: Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study. Diabetes Care. 35:119–124. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Lai SW, Liao KF, Chen PC, Tsai PY, Hsieh DP and Chen CC: Antidiabetes drugs correlate with decreased risk of lung cancer: a population-based observation in Taiwan. Clin Lung Cancer. 13:143–148. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Bodmer M, Becker C, Jick SS and Meier CR: Metformin does not alter the risk of lung cancer: a case-control analysis. Lung Cancer. 78:133–137. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Smiechowski BB, Azoulay L, Yin H, Pollak MN and Suissa S: The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care. 36:124–129. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Wells GA, Shea B, O'Connell D, et al: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.aspAccessed. February 5–2013

24 

Hsieh MC, Lee TC, Cheng SM, Tu ST, Yen MH and Tseng CH: The influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the Taiwanese. Exp Diabetes Res. 2012:4137822012. View Article : Google Scholar : PubMed/NCBI

25 

Wang SY, Chuang CS, Muo CH, et al: Metformin and the incidence of cancer in patients with diabetes: a nested case-control study. Diabetes Care. 36:e155–e156. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD and Evans JM: New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care. 32:1620–1625. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Orgel E and Mittelman SD: The links between insulin resistance, diabetes, and cancer. Curr Diab Rep. 13:213–222. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Lemke LB, Rogers AB, Nambiar PR and Fox JG: Obesity and non-insulin-dependent diabetes mellitus in Swiss-Webster mice associated with late-onset hepatocellular carcinoma. J Endocrinol. 199:21–32. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Sugiyama T, Nakanishi M, Hoshimoto K, et al: Severely fluctuating blood glucose levels associated with a somatostatin-producing ovarian neuroendocrine tumor. J Clin Endocrinol Metab. 97:3845–3850. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Pisani P: Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies. Arch Physiol Biochem. 114:63–70. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Thakkar B, Aronis KN, Vamvini MT, Shields K and Mantzoros CS: Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies. Metabolism. 62:922–934. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Chang CH, Lin JW, Wu LC, Lai MS and Chuang LM: Oral insulin secretagogues, insulin, and cancer risk in type 2 diabetes mellitus. J Clin Endocrinol Metab. 97:E1170–E1175. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Kao CH, Sun LM, Chen PC, et al: A population-based cohort study in Taiwan - use of insulin sensitizers can decrease cancer risk in diabetic patients? Ann Oncol. 24:523–530. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Colmers IN, Bowker SL and Johnson JA: Thiazolidinedione use and cancer incidence in type 2 diabetes: a systematic review and meta-analysis. Diabetes Metab. 38:475–484. 2012. View Article : Google Scholar : PubMed/NCBI

35 

van Staa TP, Patel D, Gallagher AM and de Bruin ML: Glucose-lowering agents and the patterns of risk for cancer: a study with the General Practice Research Database and secondary care data. Diabetologia. 55:654–665. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu N, Zhang Y, Gong Y, He J and Chen X: Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis. Biomed Rep 3: 235-241, 2015.
APA
Zhu, N., Zhang, Y., Gong, Y., He, J., & Chen, X. (2015). Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis. Biomedical Reports, 3, 235-241. https://doi.org/10.3892/br.2015.417
MLA
Zhu, N., Zhang, Y., Gong, Y., He, J., Chen, X."Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis". Biomedical Reports 3.2 (2015): 235-241.
Chicago
Zhu, N., Zhang, Y., Gong, Y., He, J., Chen, X."Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis". Biomedical Reports 3, no. 2 (2015): 235-241. https://doi.org/10.3892/br.2015.417
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu N, Zhang Y, Gong Y, He J and Chen X: Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis. Biomed Rep 3: 235-241, 2015.
APA
Zhu, N., Zhang, Y., Gong, Y., He, J., & Chen, X. (2015). Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis. Biomedical Reports, 3, 235-241. https://doi.org/10.3892/br.2015.417
MLA
Zhu, N., Zhang, Y., Gong, Y., He, J., Chen, X."Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis". Biomedical Reports 3.2 (2015): 235-241.
Chicago
Zhu, N., Zhang, Y., Gong, Y., He, J., Chen, X."Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta‑analysis". Biomedical Reports 3, no. 2 (2015): 235-241. https://doi.org/10.3892/br.2015.417
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team