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Article

Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques

  • Authors:
    • Yapei Guo
    • Tiantian Liu
    • Xueyuan Li
    • Min Zhang
    • Lei Shi
    • Hengfang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Fifth Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
  • Pages: 398-402
    |
    Published online on: January 29, 2015
       https://doi.org/10.3892/br.2015.421
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Abstract

There is increasing evidence showing that inflammation occurs in atherosclerosis and contributes to the formation of atherosclerotic plaques. As important inflammatory peptides, kinins are increased in inflammation, eliciting vasodilation, increasing vascular permeability and recruiting inflammatory cells to the injury sites by activating specific receptors, B1 and B2. The two receptors have been reported to increase in inflammation, but their expressions remain to be defined in human carotid atherosclerotic plaques (CAP). In order to assess the gene expression of kinin receptors in human CAP, 47 CAP specimens were collected from patients undergoing endarterectomy and classified into stable and unstable plaque groups, respectively, with 10 mesenteric arteries used as controls. Total mRNA of B1R and B2R was extracted from CAPs and their levels were determined using reverse transcription‑polymerase chain reaction. The expression of B1R and B2R mRNA was significantly upregulated in human CAPs compared to the control arteries. In the unstable plaques, the ratios of B1R to the β‑actin mRNA level were significantly increased relative to the stable plaques. However, no notable differences were observed in the ratios of B2R to β‑actin in mRNA expression between the stable and unstable plaques. The present study suggests that kinin‑mediated inflammation involves the formation of atherosclerotic plaque and B1R plays an important role in plaque instability, indicating that kinin receptors can be used as potential targets for future therapeutic interventions.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Liu T, Li X, Zhang M, Shi L and Liu H: Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques. Biomed Rep 3: 398-402, 2015.
APA
Guo, Y., Liu, T., Li, X., Zhang, M., Shi, L., & Liu, H. (2015). Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques. Biomedical Reports, 3, 398-402. https://doi.org/10.3892/br.2015.421
MLA
Guo, Y., Liu, T., Li, X., Zhang, M., Shi, L., Liu, H."Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques". Biomedical Reports 3.3 (2015): 398-402.
Chicago
Guo, Y., Liu, T., Li, X., Zhang, M., Shi, L., Liu, H."Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques". Biomedical Reports 3, no. 3 (2015): 398-402. https://doi.org/10.3892/br.2015.421
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Liu T, Li X, Zhang M, Shi L and Liu H: Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques. Biomed Rep 3: 398-402, 2015.
APA
Guo, Y., Liu, T., Li, X., Zhang, M., Shi, L., & Liu, H. (2015). Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques. Biomedical Reports, 3, 398-402. https://doi.org/10.3892/br.2015.421
MLA
Guo, Y., Liu, T., Li, X., Zhang, M., Shi, L., Liu, H."Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques". Biomedical Reports 3.3 (2015): 398-402.
Chicago
Guo, Y., Liu, T., Li, X., Zhang, M., Shi, L., Liu, H."Expression of the genes encoding kinin receptors are increased in human carotid atherosclerotic plaques". Biomedical Reports 3, no. 3 (2015): 398-402. https://doi.org/10.3892/br.2015.421
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