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Article

Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study

  • Authors:
    • Takuya Fukuda
    • Michiaki Fukui
    • Muhei Tanaka
    • Takafumi  Senmaru
    • Hiroya Iwase
    • Masahiro Yamazaki
    • Wataru Aoi
    • Toshio  Inui
    • Naoto Nakamura
    • Yoshinori Marunaka
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602‑8566, Japan, Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606‑8522, Japan, Departments of Molecular Cell Physiology and Bio‑Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602‑8566, Japan
  • Pages: 355-360
    |
    Published online on: February 25, 2015
       https://doi.org/10.3892/br.2015.436
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Abstract

Propolis contains a variety of chemical compounds, including polyphenols, flavonoids, phenolic aldehydes, amino acids and vitamins, and presents numerous biological and pharmacological properties. The aim of the present study was to evaluate the effect of propolis on blood examination data in patients with type 2 diabetes. In the double‑blind, 8‑week randomized controlled study, 80 patients with type 2 diabetes were enrolled. Patients were randomly assigned to receive Brazilian green propolis (226.8 mg/day for 8 weeks) (n=41) or the placebo (n=39). The primary endpoint was to detect changes in blood examination data associated with metabolic disorders in patients suffering from diabetes mellitus, including the homeostasis model assessment of insulin resistance (HOMA‑IR), uric acid and estimated glomerular filtration rate (eGFR) from baseline to the end of this study. The value of HOMA‑IR was not significantly changed by the 8‑week administration of propolis or placebo from the baseline data. Values of blood uric acid and eGFR in patients taking the placebo became worse at 8 weeks compared to the baseline, whereas this did not occur in patients consuming Brazilian green propolis. However, HOMA‑IR was not improved by propolis intake. A randomized, controlled 8‑week trial suggests that Brazilian green propolis (226.8 mg/day) prevents patients with type 2 diabetes from developing worse blood uric acid and eGFR.
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Copy and paste a formatted citation
Spandidos Publications style
Fukuda T, Fukui M, Tanaka M, Senmaru T, Iwase H, Yamazaki M, Aoi W, Inui T, Nakamura N, Marunaka Y, Marunaka Y, et al: Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. Biomed Rep 3: 355-360, 2015.
APA
Fukuda, T., Fukui, M., Tanaka, M., Senmaru, T., Iwase, H., Yamazaki, M. ... Marunaka, Y. (2015). Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. Biomedical Reports, 3, 355-360. https://doi.org/10.3892/br.2015.436
MLA
Fukuda, T., Fukui, M., Tanaka, M., Senmaru, T., Iwase, H., Yamazaki, M., Aoi, W., Inui, T., Nakamura, N., Marunaka, Y."Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study". Biomedical Reports 3.3 (2015): 355-360.
Chicago
Fukuda, T., Fukui, M., Tanaka, M., Senmaru, T., Iwase, H., Yamazaki, M., Aoi, W., Inui, T., Nakamura, N., Marunaka, Y."Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study". Biomedical Reports 3, no. 3 (2015): 355-360. https://doi.org/10.3892/br.2015.436
Copy and paste a formatted citation
x
Spandidos Publications style
Fukuda T, Fukui M, Tanaka M, Senmaru T, Iwase H, Yamazaki M, Aoi W, Inui T, Nakamura N, Marunaka Y, Marunaka Y, et al: Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. Biomed Rep 3: 355-360, 2015.
APA
Fukuda, T., Fukui, M., Tanaka, M., Senmaru, T., Iwase, H., Yamazaki, M. ... Marunaka, Y. (2015). Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. Biomedical Reports, 3, 355-360. https://doi.org/10.3892/br.2015.436
MLA
Fukuda, T., Fukui, M., Tanaka, M., Senmaru, T., Iwase, H., Yamazaki, M., Aoi, W., Inui, T., Nakamura, N., Marunaka, Y."Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study". Biomedical Reports 3.3 (2015): 355-360.
Chicago
Fukuda, T., Fukui, M., Tanaka, M., Senmaru, T., Iwase, H., Yamazaki, M., Aoi, W., Inui, T., Nakamura, N., Marunaka, Y."Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study". Biomedical Reports 3, no. 3 (2015): 355-360. https://doi.org/10.3892/br.2015.436
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