Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
May-2015 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2015 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats

  • Authors:
    • Li Wang
    • Fadong Liu
    • Yan Luo
    • Lingqin Zhu
    • Guanghua Li
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China
  • Pages: 425-429
    |
    Published online on: March 20, 2015
       https://doi.org/10.3892/br.2015.445
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

The aim of the present study was to investigate the effect of acute heat stress on the neuroendocrine and immunological function in rats. Male Sprague‑Dawley rats were randomly divided into two groups and respectively exposed to heat (32˚C) or to room temperature (24˚C). After 7 days of heat exposure, the heat‑stress rat model was established. The organ coefficients of the pituitary and adrenal glands were determined. The body temperature was measured by telemetry. The average contents of adrenocorticotropic hormone (ACTH), cortisol (Cor), interleukin‑2 (IL‑2) and IL‑12 in serum were detected. The expression of apoptotic genes in the spleen was measured. The results showed that acute heat stress did not evidently affect the body temperature and body weight (P>0.05), but the exposure increased the organ coefficients of the pituitary and adrenal glands (P<0.05). Heat exposure significantly elevated the level of ACTH, Cor, IL‑2 and IL‑12 (P<0.05). The expression of caspase‑3 and Bax were not changed significantly (P>0.05), while Bcl2 was reduced (P<0.05).
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Shi YJ, Yu JR, Cen XN, Zhu Q and Ren HY: Influence of HSP70 on combined method of hyperthermia and immunologic effector cells to treat cancer. Beijing Da Xue Xue Bao. 37:175–178. 2005.(In Chinese). PubMed/NCBI

2 

Maglara AA, Vasilaki A, Jackson MJ and McArdle A: Damage to developing mouse skeletal muscle myotubes in culture: Protective effect of heat shock proteins. J Physiol. 548:837–846. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Kim Y, Kim J, Kim M, Baek W and Kim I: Effect of heat shock on the vascular contractility in isolated rat aorta. J Pharmacol Toxicol Methods. 42:171–174. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Atkinson HC, Wood SA, Kershaw YM, Bate E and Lightman SL: Diurnal variation in the responsiveness of the hypothalamic-pituitary-adrenal axis of the male rat to noise stress. J Neuroendocrinol. 18:526–533. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Dong Q and Liu X: Effect of fear stress in rats on the contents of ACTH, CORT, IL 2, IL 8. J Mol Diagn Ther. 5:173–176. 2013.

6 

Watanabe T, Fujioka T, Hashimoto M and Nakamura S: Stress and brain angiotensin II receptors. Crit Rev Neurobiol. 12:305–317. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Padgett DA and Glaser R: How stress influences the immune response. Trends Immunol. 24:444–448. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Fadok VA, Bratton DL and Henson PM: Phagocyte receptors for apoptotic cells: Recognition, uptake and consequences. J Clin Invest. 108:957–962. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Urban BC, Willcox N and Roberts DJ: A role for CD36 in the regulation of dendritic cell function. Proc Natl Acad Sci USA. 98:8750–8755. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Garrett AT, Creasy R, Rehrer NJ, Patterson MJ and Cotter JD: Effectiveness of short-term heat acclimation for highly trained athletes. Eur J Appl Physiol. 112:1827–1837. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Brazaitis M and Skurvydas A: Heat acclimation does not reduce the impact of hyperthermia on central fatigue. Eur J Appl Physiol. 109:771–778. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Fujii N, Honda Y, Ogawa T, Tsuji B, Kondo N, Koga S and Nishiyasu T: Short-term exercise-heat acclimation enhances skin vasodilation but not hyperthermic hyperpnea in humans exercising in a hot environment. Eur J Appl Physiol. 112:295–307. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Liu X, Cui Y, Yang Y, et al: Study on neuroendocrine mechanism of occurence of cerebral infarction in hypertension rats induced by soaring temperature. Prog Mod Biomed. 11:1428–1431. 2011.

14 

Hannon MJ and O'Halloran DJ: Isolated acquired ACTH deficiency and primary hypothyroidism: A short series and review. Pituitary. 14:358–361. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Beleen C, Martinez Fuentes AJ and Gracia Navarro F: Role of SST, COR and ghrelin and its receptors at the endocrine pancreas. Front Endocrinol. 3:1142012. View Article : Google Scholar

16 

Servatius RJ, Beck KD, Moldow RL, Salameh G, Tumminello TP and Short KR: A stress-induced anxious state in male rats: Corticotropin-releasing hormone induces persistent changes in associative learning and startle reactivity. Biol Psychiatry. 57:865–872. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Serra M, Pisu MG, Floris I and Biggio G: Social isolation-induced changes in the hypothalamic-pituitary-adrenal axis in the rat. Stress. 8:259–264. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Clarke BL, Gebhardt BM and Blalock JE: Mitogen-stimulated lymphocytes release biologically active corticotropin. Endocrinology. 132:983–988. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Kravchenco IV and Furalev VA: Secretion of immunoreactive corticotropin releasing factor and adrenocorticotropic hormone by T- and B-lymphocytes in response to cellular stress factors. Biochem Biophys Res Commun. 204:828–834. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Wermerskirchen AS, LaTocha DH and Clarke BL: Adrenocorticotropic hormone controls Concanavalin A activation of rat lymphocytes by modulating IL-2 production. Life Sci. 67:2177–2187. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Horowitz M: From molecular and cellular to integrative heat defense during exposure to chronic heat. Comp Biochem Physiol A Mol Integr Physiol. 131:475–483. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Johnson JS, Boddicker RL, Sanz-Fernandez MV, Ross JW, Selsby JT, Lucy MC, Safranski TJ, Rhoads RP and Baumgard LH: Effects of mammalian in utero heat stress on adolescent body temperature. Int J Hyperthermia. 29:696–702. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Khajavi M, Rahimi S, Hassan ZM, Kamali MA and Mousavi T: Effect of feed restriction early in life on humoral and cellular immunity of two commercial broiler strains under heat stress conditions. Br Poult Sci. 44:490–497. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Kanikowska D, Sato M, Sugenoya J, Iwase S, Shimizu Y, Nishimura N and Inukai Y: No effects of acclimation to heat on immune and hormonal responses to passive heating in healthy volunteers. Int J Biometeorol. 56:107–112. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Johnstone RW, Ruefli AA and Lowe SW: Apoptosis: A link between cancer genetics and chemotherapy. Cell. 108:153–164. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Fesik SW and Shi Y: Structural biology. Controlling the caspases. Science. 294:1477–1478. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Liu Y, Zheng Q, Wu H, et al: The effects on expression ratio of Bax/Bcl-2 and the expression of activated caspace 3 in different types of tumor cells. Tumor. 33:138–145. 2013.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang L, Liu F, Luo Y, Zhu L and Li G: Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats. Biomed Rep 3: 425-429, 2015.
APA
Wang, L., Liu, F., Luo, Y., Zhu, L., & Li, G. (2015). Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats. Biomedical Reports, 3, 425-429. https://doi.org/10.3892/br.2015.445
MLA
Wang, L., Liu, F., Luo, Y., Zhu, L., Li, G."Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats". Biomedical Reports 3.3 (2015): 425-429.
Chicago
Wang, L., Liu, F., Luo, Y., Zhu, L., Li, G."Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats". Biomedical Reports 3, no. 3 (2015): 425-429. https://doi.org/10.3892/br.2015.445
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Liu F, Luo Y, Zhu L and Li G: Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats. Biomed Rep 3: 425-429, 2015.
APA
Wang, L., Liu, F., Luo, Y., Zhu, L., & Li, G. (2015). Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats. Biomedical Reports, 3, 425-429. https://doi.org/10.3892/br.2015.445
MLA
Wang, L., Liu, F., Luo, Y., Zhu, L., Li, G."Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats". Biomedical Reports 3.3 (2015): 425-429.
Chicago
Wang, L., Liu, F., Luo, Y., Zhu, L., Li, G."Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin‑2, interleukin‑12 and apoptosis gene expression in rats". Biomedical Reports 3, no. 3 (2015): 425-429. https://doi.org/10.3892/br.2015.445
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team