Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-2015 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke

  • Authors:
    • Yuichiro Yamase
    • Hideki Horibe
    • Chikara Ueyama
    • Tetsuo Fujimaki
    • Mitsutoshi Oguri
    • Kimihiko Kato
    • Masazumi Arai
    • Sachiro Watanabe
    • Yoshiji Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507‑8522, Japan, Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie 511‑0428, Japan, Department of Cardiology, Kasugai Municipal Hospital, Kasugai, Aichi 486‑8510, Japan, Department of Internal Medicine, Meitoh Hospital, Nagoya, Aichi 465‑0025, Japan, Department of Cardiology, Gifu Prefectural General Medical Center, Gifu 500‑8717, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514‑8507, Japan
  • Pages: 491-498
    |
    Published online on: April 29, 2015
       https://doi.org/10.3892/br.2015.457
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recent genome-wide association studies (GWASs) and their meta-analyses have identified various genes and loci underlying the predisposition to ischemic stroke or coronary artery disease in Caucasian populations. Given that ischemic stroke and coronary artery disease may have a shared genetic architecture, certain polymorphisms may confer genetic susceptibility to these two diseases. The aim of the present study was to examine the possible association of ischemic stroke with 29 single‑nucleotide polymorphisms (SNPs) previously identified by the meta‑analyses of GWASs as susceptibility loci for coronary artery disease. The study population comprised 3,187 Japanese individuals, including 894 subjects with ischemic stroke and 2,293 controls. The genotypes for the 29 SNPs of the 28 genes were determined by a method that combines the polymerase chain reaction and sequence‑specific oligonucleotide probes with suspension array technology. Comparisons of the allele frequencies by the χ2 test between subjects with ischemic stroke and controls revealed that rs9319428 (G→A) of the fms‑related tyrosine kinase 1 gene (P=0.0471), rs2075650 (G→A) of the translocase of outer mitochondrial membrane 40 homolog gene (TOMM40, P=0.0102) and rs273909 (T→C) of the solute carrier family 22, member 4 gene (SLC22A4, P=0.0097) were significantly (P<0.05) associated with the prevalence of ischemic stroke. Multivariable logistic regression analysis with adjustment for age, gender, body mass index, smoking status and the prevalence of hypertension, diabetes mellitus and dyslipidemia revealed that rs2075650 of TOMM40 (P=0.0443; recessive model; odds ratio=0.50) and rs273909 of SLC22A4 (P=0.0123; dominant model; odds ratio=0.45) were significantly associated with ischemic stroke with the minor G and C allele, respectively, being protective against this condition. TOMM40 and SLC22A4 may thus be susceptibility loci for ischemic stroke in Japanese individuals.
View Figures
View References

1 

Tournier-Lasserve E: New players in the genetics of stroke. N Engl J Med. 347:1711–1712. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Bak S, Gaist D, Sindrup SH, Skytthe A and Christensen K: Genetic liability in stroke: A long-term follow-up study of Danish twins. Stroke. 33:769–774. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, et al: American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics - 2014 update: A report from the American Heart Association. Circulation. 129:e28–e292. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Bonita R: Epidemiology of stroke. Lancet. 339:342–344. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Warlow C, Sudlow C, Dennis M, Wardlaw J and Sandercock P: Stroke. Lancet. 362:1211–1224. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Dichgans M: Genetics of ischaemic stroke. Lancet Neurol. 6:149–161. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Roberts R and Stewart AF: The genetics of coronary artery disease. Curr Opin Cardiol. 27:221–227. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Banerjee A, Lim CC, Silver LE, Welch SJ, Banning AP and Rothwell PM: Familial history of stroke is associated with acute coronary syndromes in women. Circ Cardiovasc Genet. 4:9–15. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, et al: Genomewide association studies of stroke. N Engl J Med. 360:1718–1728. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Matarín M, Brown WM, Scholz S, Simón-Sánchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, et al: A genome-wide genotyping study in patients with ischaemic stroke: Initial analysis and data release. Lancet Neurol. 6:414–420. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Yamada Y, Fuku N, Tanaka M, Aoyagi Y, Sawabe M, Metoki N, Yoshida H, Satoh K, Kato K, Watanabe S, et al: Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 207:144–149. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA, Malik R, Bevan S, et al: Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2); International Stroke Genetics Consortium: Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): A meta-analysis of genome-wide association studies. Lancet Neurol. 11:951–962. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Holliday EG, Maguire JM, Evans TJ, Koblar SA, Jannes J, Sturm JW, Hankey GJ, Baker R, Golledge J, Parsons MW, et al: Australian Stroke Genetics Collaborative; International Stroke Genetics Consortium; Wellcome Trust Case Control Consortium 2: Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet. 44:1147–1151. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, et al: Cardiogenics; CARDIoGRAM Consortium: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43:333–338. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, et al: CARDIoGRAMplusC4D Consortium; DIAGRAM Consortium; CARDIOGENICS Consortium; MuTHER Consortium; Wellcome Trust Case Control Consortium: Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 45:25–33. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, Meitinger T, Wichmann E, Mitchell BD, Furie K, et al: International Stroke Genetics Consortium: Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. Ann Neurol. 65:531–539. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PM, et al: EuroCLOT Investigators; Wellcome Trust Case Control Consortium 2; MOnica Risk, Genetics, Archiving and Monograph; MetaStroke; International Stroke Genetics Consortium: Ischemic stroke is associated with the ABO locus: The EuroCLOT study. Ann Neurol. 73:16–31. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, Thorleifsson G, Mitchell BD, Assimes TL, Levi C, et al: METASTROKE Consortium; CARDIoGRAM Consortium; C4D Consortium; International Stroke Genetics Consortium: Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants. Stroke. 45:24–36. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Special report from the National Institute of Neurological Disorders and Stroke. Classification of cerebrovascular diseases III. Stroke. 21:637–676. 1990. View Article : Google Scholar : PubMed/NCBI

20 

Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H and Hishida A: Collaborators developing the Japanese equation for estimated GFR: Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 53:982–992. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Matsuoka R, Abe S, Tokoro F, et al: Association of six genetic variants with myocardial infarction. Int J Mol Med. 35:1451–1459. 2015.PubMed/NCBI

22 

Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, et al: Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. Atherosclerosis. 215:145–152. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Yamada Y, Nishida T, Ichihara S, et al: Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study. J Med Genet. 50:410–418. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Itoh Y, Mizuki N, Shimada T, Azuma F, Itakura M, Kashiwase K, Kikkawa E, Kulski JK, Satake M and Inoko H: High-throughput DNA typing of HLA-A, -B, -C and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics. 57:717–729. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Koehler CM, Merchant S and Schatz G: How membrane proteins travel across the mitochondrial intermembrane space. Trends Biochem Sci. 24:428–432. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ and Ryan MT: Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 280:11535–11543. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Deelen J, Beekman M, Uh HW, et al: Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell. 10:686–698. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Feulner TM, Laws SM, Friedrich P, Wagenpfeil S, Wurst SH, Riehle C, Kuhn KA, Krawczak M, Schreiber S, Nikolaus S, et al: Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry. 15:756–766. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Aulchenko YS, Ripatti S, Lindqvist I, et al: ENGAGE Consortium: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 41:47–55. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Reiner AP, Barber MJ, Guan Y, Ridker PM, Lange LA, Chasman DI, Walston JD, Cooper GM, Jenny NS, Rieder MJ, et al: Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. Am J Hum Genet. 82:1193–1201. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Ronald J, Rajagopalan R, Ranchalis JE, Marshall JK, Hatsukami TS, Heagerty PJ and Jarvik GP: Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease. Lipids Health Dis. 8:522009. View Article : Google Scholar : PubMed/NCBI

32 

Bekris LM, Lutz F and Yu CE: Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. J Hum Genet. 57:18–25. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, Keavney B, Collins R, Wiman B, de Faire U, et al: Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA. 298:1300–1311. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Bagyinszky E, Youn YC, An SS and Kim S: The genetics of Alzheimer's disease. Clin Interv Aging. 9:535–551. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, Cooper J, Talmud PJ, Humphries SE, Sundstrom J, et al: Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. Int J Epidemiol. 42:475–492. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Bleasby K, Castle JC, Roberts CJ, Cheng C, Bailey WJ, Sina JF, Kulkarni AV, Hafey MJ, Evers R, Johnson JM, et al: Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition. Xenobiotica. 36:963–988. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Mitsuyama H and May JM: Uptake and antioxidant effects of ergothioneine in human erythrocytes. Clin Sci (Lond). 97:407–411. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Aruoma OI, Spencer JP and Mahmood N: Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food Chem Toxicol. 37:1043–1053. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Sakrak O, Kerem M, Bedirli A, Pasaoglu H, Akyurek N, Ofluoglu E and Gültekin FA: Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury. J Surg Res. 144:36–42. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Martin KR: The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease. J Med Food. 13:1340–1346. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Akanmu D, Cecchini R, Aruoma OI and Halliwell B: The antioxidant action of ergothioneine. Arch Biochem Biophys. 288:10–16. 1991. View Article : Google Scholar : PubMed/NCBI

42 

Cheah IK and Halliwell B: Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim Biophys Acta. 1822:784–793. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cescon D, Greenberg G, et al: Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet. 36:471–475. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Waller S, Tremelling M, Bredin F, Godfrey L, Howson J and Parkes M: Evidence for association of OCTN genes and IBD5 with ulcerative colitis. Gut. 55:809–814. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, et al: An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet. 35:341–348. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Santiago JL, Martínez A, de la Calle H, Fernández-Arquero M, Figueredo MA, de la Concha EG and Urcelay E: Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: A case control study. BMC Med Genet. 7:542006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yamase Y, Horibe H, Ueyama C, Fujimaki T, Oguri M, Kato K, Arai M, Watanabe S and Yamada Y: Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. Biomed Rep 3: 491-498, 2015.
APA
Yamase, Y., Horibe, H., Ueyama, C., Fujimaki, T., Oguri, M., Kato, K. ... Yamada, Y. (2015). Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. Biomedical Reports, 3, 491-498. https://doi.org/10.3892/br.2015.457
MLA
Yamase, Y., Horibe, H., Ueyama, C., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Yamada, Y."Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke". Biomedical Reports 3.4 (2015): 491-498.
Chicago
Yamase, Y., Horibe, H., Ueyama, C., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Yamada, Y."Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke". Biomedical Reports 3, no. 4 (2015): 491-498. https://doi.org/10.3892/br.2015.457
Copy and paste a formatted citation
x
Spandidos Publications style
Yamase Y, Horibe H, Ueyama C, Fujimaki T, Oguri M, Kato K, Arai M, Watanabe S and Yamada Y: Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. Biomed Rep 3: 491-498, 2015.
APA
Yamase, Y., Horibe, H., Ueyama, C., Fujimaki, T., Oguri, M., Kato, K. ... Yamada, Y. (2015). Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. Biomedical Reports, 3, 491-498. https://doi.org/10.3892/br.2015.457
MLA
Yamase, Y., Horibe, H., Ueyama, C., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Yamada, Y."Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke". Biomedical Reports 3.4 (2015): 491-498.
Chicago
Yamase, Y., Horibe, H., Ueyama, C., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Yamada, Y."Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke". Biomedical Reports 3, no. 4 (2015): 491-498. https://doi.org/10.3892/br.2015.457
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team