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Article

Effects of curcumin on the gene expression profile of L-02 cells

  • Authors:
    • Mingjie Zhou
    • Chunlei Fan
    • Nan Tian
  • View Affiliations / Copyright

    Affiliations: College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China
  • Pages: 519-526
    |
    Published online on: May 4, 2015
       https://doi.org/10.3892/br.2015.460
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Abstract

Curcumin has been utilized in the treatment and prevention of disease, including cancer and cardiovascular disease, but the molecular mechanism behind such numerous effects remains unclear. To explore the molecular mechanism and action sites of curcumin at the cellular level, human hepatic L‑02 cells were used to assess these effects. Microarray technology was employed to detect the gene expression of L‑02 cells treated with curcumin. According to the microarray results and the data from the National Center for Biotechnology Information, the present study classified and concluded that these curcumin‑sensitive genes were associated with diseases and their signaling pathway. The study supports the evidence for treating cancer and cardiovascular disease, and found certain potential marker genes for conducting systematic research into the effects of curcumin. A total of 80 genes were identified as significantly differentially expressed between samples treated with and without curcumin. Curcumin is capable of developing physiological reactions and functions by regulating the gene expression and affecting its signal transduction pathway. Tumor protein p63, MYC‑associated factor X and certain other genes associated with tumors act on a potential therapeutic target, while apolipoprotein B receptor and oxysterol‑binding protein‑like 7, and their signaling pathways may be involved in the cardioprotective effects of curcumin.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou M, Fan C and Tian N: Effects of curcumin on the gene expression profile of L-02 cells. Biomed Rep 3: 519-526, 2015.
APA
Zhou, M., Fan, C., & Tian, N. (2015). Effects of curcumin on the gene expression profile of L-02 cells. Biomedical Reports, 3, 519-526. https://doi.org/10.3892/br.2015.460
MLA
Zhou, M., Fan, C., Tian, N."Effects of curcumin on the gene expression profile of L-02 cells". Biomedical Reports 3.4 (2015): 519-526.
Chicago
Zhou, M., Fan, C., Tian, N."Effects of curcumin on the gene expression profile of L-02 cells". Biomedical Reports 3, no. 4 (2015): 519-526. https://doi.org/10.3892/br.2015.460
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou M, Fan C and Tian N: Effects of curcumin on the gene expression profile of L-02 cells. Biomed Rep 3: 519-526, 2015.
APA
Zhou, M., Fan, C., & Tian, N. (2015). Effects of curcumin on the gene expression profile of L-02 cells. Biomedical Reports, 3, 519-526. https://doi.org/10.3892/br.2015.460
MLA
Zhou, M., Fan, C., Tian, N."Effects of curcumin on the gene expression profile of L-02 cells". Biomedical Reports 3.4 (2015): 519-526.
Chicago
Zhou, M., Fan, C., Tian, N."Effects of curcumin on the gene expression profile of L-02 cells". Biomedical Reports 3, no. 4 (2015): 519-526. https://doi.org/10.3892/br.2015.460
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