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Article

Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells

  • Authors:
    • Yuan Wang
    • Peng‑Cheng He
    • Jun Qi
    • Yan‑Feng Liu
    • Mei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, P.R. China, Institute of Xi'an Blood Bank, Shaanxi Blood Center, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 583-587
    |
    Published online on: May 21, 2015
       https://doi.org/10.3892/br.2015.466
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Abstract

Previous studies have shown that the therapeutic action of tetra-arsenic tetra-sulfide (As4S4) is effective for acute promyelocytic leukemia. However, the molecular mechanism of the action of As4S4 in retinoic acid-resistant acute promyelocytic leukemia (APL) therapy remains unclear. In the present study, the signaling of the cytotoxic effects induced by As4S4 on retinoic acid‑resistant APL NB4‑R1 cells was investigated. A time‑dependent increase in cell death and DNA cleavage was observed following As4S4 treatment. Changes in B‑cell lymphoma 2 and Bax accompanied by the activation of caspase‑3 and cleavage of poly ADP‑ribose polymerase were observed as actions of As4S4. As4S4 induced an accumulation of NB4‑R1 cells in the S and G2/M phases, as detected by flow cytometry. Therefore, the present results suggest that As4S4‑mediated apoptosis in NB4-R1 cells involves a mitochondria-dependent pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, He PC, Qi J, Liu YF and Zhang M: Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells. Biomed Rep 3: 583-587, 2015.
APA
Wang, Y., He, P., Qi, J., Liu, Y., & Zhang, M. (2015). Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells. Biomedical Reports, 3, 583-587. https://doi.org/10.3892/br.2015.466
MLA
Wang, Y., He, P., Qi, J., Liu, Y., Zhang, M."Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells". Biomedical Reports 3.4 (2015): 583-587.
Chicago
Wang, Y., He, P., Qi, J., Liu, Y., Zhang, M."Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells". Biomedical Reports 3, no. 4 (2015): 583-587. https://doi.org/10.3892/br.2015.466
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, He PC, Qi J, Liu YF and Zhang M: Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells. Biomed Rep 3: 583-587, 2015.
APA
Wang, Y., He, P., Qi, J., Liu, Y., & Zhang, M. (2015). Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells. Biomedical Reports, 3, 583-587. https://doi.org/10.3892/br.2015.466
MLA
Wang, Y., He, P., Qi, J., Liu, Y., Zhang, M."Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells". Biomedical Reports 3.4 (2015): 583-587.
Chicago
Wang, Y., He, P., Qi, J., Liu, Y., Zhang, M."Tetra-arsenic tetra-sulfide induces cell cycle arrest and apoptosis in retinoic acid-resistant acute promyelocytic leukemia cells". Biomedical Reports 3, no. 4 (2015): 583-587. https://doi.org/10.3892/br.2015.466
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