Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

Kumagai,Kenichi; Suzuki,Satsuki; Kanri,Yoriaki; Matsubara,Ryota; Fujii,Keisuke; Wake,Masahiro; Suzuki,Ryuji; Hamada,Yoshiki

doi:10.3892/br.2015.467

July-2015 Volume 3 Issue 4

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July-2015 Volume 3 Issue 4

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Article Open Access

Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

Authors:
- Kenichi Kumagai
- Satsuki Suzuki
- Yoriaki Kanri
- Ryota Matsubara
- Keisuke Fujii
- Masahiro Wake
- Ryuji Suzuki
- Yoshiki Hamada
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Affiliations: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa 230‑8501, Japan, Section of Biological Science Research Center for Odontology, School of Dentistry, Nippon Dental University, Tokyo 102‑8159, Japan, Department of Pathology, School of Life Dentistry at Niigata, The Nippon Dental University, Niigata, Niigata 951‑8580, Japan, Department of Oral and Maxillofacial Surgery, Sagamihara Kyodo Hospital, Sagamihara, Kanagawa 252-0143, Japan, Department of Oral and Maxillofacial Surgery, Sendai Tokushukai Hospital, Sendai, Miyagi 981‑3131, Japan, Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Kanagawa 228‑0815, Japan

Copyright: © Kumagai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 453-456
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Published online on: May 21, 2015

https://doi.org/10.3892/br.2015.467
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Abstract

Temporomandibular joint (TMJ) osteoarthritis is typically a slowly progressive asymmetric disease. Little is known regarding the natural destruction of TMJ articular tissues. The aim of the present study was to investigate morphological changes in the TMJ of STR/ort mice, known to be the model for spontaneous osteoarthritis in the knee joint, and to evaluate STR/ort mice as a suitable animal model for TMJ osteoarthritis. TMJs from 32 STR/ort mice euthanized at 30, 40, 50 or 60 weeks of age, and from 6 CBA mice euthanized at 30, 40 or 60 weeks of age were examined. Toluidine blue and tartrate‑resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using microcomputed tomography. At the age of 40‑50 weeks, 17 (68%) of the 25 STR/ort mice had loss of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by microcomputed tomography. The STR/ort mouse strain appears to develop spontaneous osteoarthritis‑like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

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