Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review)

  • Authors:
    • Qian Wu
    • Hua Qin
    • Qiu Zhao
    • Xing‑Xing He
  • View Affiliations / Copyright

    Affiliations: Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 611-616
    |
    Published online on: June 11, 2015
       https://doi.org/10.3892/br.2015.477
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Transcriptional regulatory networks are biological network motifs that act in accordance with each other to play decisive roles in the pathological processes of cancer. One of the most common types, the feed‑forward loop (FFL), has recently attracted interest. Three connected deregulated nodes, a transcription factor (TF), its downstream microRNA (miRNA) and their shared target gene can make up a class of cancer‑involved FFLs as ≥1 of the 3 can act individually as a bona fide oncogene or a tumor suppressor. Numerous notable elements, such as p53, miR‑17‑92 cluster and cyclins, are proven members of their respective FFLs. Databases of interaction prediction, verification of experimental methods and confirmation of loops have been continually emerging during recent years. Development of TF‑miRNA‑target loops may help understand the mechanism of tumorgenesis at a higher level and explain the discovery and screening of the therapeutic target for drug exploitation.
View Figures

Figure 1

View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Milo R, Shen-Orr S, Itzkovitz S, Kashtan N, Chklovskii D and Alon U: Network motifs: Simple building blocks of complex networks. Science. 298:824–827. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Widder S, Solé R and Macía J: Evolvability of feed-forward loop architecture biases its abundance in transcription networks. BMC Syst Biol. 6:72012. View Article : Google Scholar : PubMed/NCBI

4 

Shen-Orr SS, Milo R, Mangan S and Alon U: Network motifs in the transcriptional regulation network of Escherichia coli. Nat Genet. 31:64–68. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Re A, Corá D, Taverna D and Caselle M: Genome-wide survey of microRNA-transcription factor feed-forward regulatory circuits in human. Mol Biosyst. 5:854–867. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Ma HW, Kumar B, Ditges U, Gunzer F, Buer J and Zeng AP: An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs. Nucleic Acids Res. 32:6643–6649. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Mangan S and Alon U: Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci USA. 100:11980–11985. 2003. View Article : Google Scholar : PubMed/NCBI

8 

He XX, Guo AY, Xu CR, et al: Bioinformatics analysis identifies miR-221 as a core regulator in hepatocellular carcinoma and its silencing suppresses tumor properties. Oncol Rep. 32:1200–1210. 2014.PubMed/NCBI

9 

Yan JW, Lin JS and He XX: The emerging role of miR-375 in cancer. Int J Cancer. 135:1011–1018. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Li Y, Liang C, Easterbrook S, Luo J and Zhang Z: Investigating the functional implications of reinforcing feedback loops in transcriptional regulatory networks. Mol Biosys. 10:3238–3248. 2014. View Article : Google Scholar

11 

Fujita Y, Komatsu N, Matsuda M and Aoki K: Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. FEBS J. 281:3177–3192. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Hsieh WT, Tzeng KR, Ciou JS, Tsai JJ, Kurubanjerdjit N, Huang CH, et al: Transcription factor and microRNA-regulated network motifs for cancer and signal transduction networks. BMC Syst Biol. 9:(Suppl 1). S52015. View Article : Google Scholar : PubMed/NCBI

13 

Latchman DS: Transcription factors: An overview. Int J Biochem Cell Biol. 29:1305–1312. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Mitchell PJ and Tjian R: Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science. 245:371–378. 1989. View Article : Google Scholar : PubMed/NCBI

15 

Ptashne M and Gann A: Transcriptional activation by recruitment. Nature. 386:569–577. 1997. View Article : Google Scholar : PubMed/NCBI

16 

van Nimwegen E: Scaling laws in the functional content of genomes. Trends Genet. 19:479–484. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Lane D and Levine A: p53 Research: The past thirty years and the next thirty years. Cold Spring Harb Perspect Biol. 2:a0008932010. View Article : Google Scholar : PubMed/NCBI

18 

Hainaut P and Wiman KG: 30 years and a long way into p53 research. Lancet Oncol. 10:913–919. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Hermeking H: p53 enters the microRNA world. Cancer Cell. 12:414–418. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, et al: p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol. 4:2292008. View Article : Google Scholar : PubMed/NCBI

21 

Altshuler ML, Severin SE and Glukhov AI: The tumor cell and telomerase. Biochemistry (Mosc). 68:1275–1283. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, et al: Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 22:209–221. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Lujambio A and Lowe SW: The microcosmos of cancer. Nature. 482:347–355. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Calin GA and Croce CM: MicroRNA-cancer connection: The beginning of a new tale. Cancer Res. 66:7390–7394. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R, Liu S, Schwind S, Santhanam R, Hickey CJ, et al: miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell. 140:652–665. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Moretti F, Thermann R and Hentze MW: Mechanism of translational regulation by miR-2 from sites in the 5′ untranslated region or the open reading frame. RNA. 16:2493–2502. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Shalgi R, Brosh R, Oren M, Pilpel Y and Rotter V: Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate. Aging (Albany NY). 1:762–770. 2009.PubMed/NCBI

30 

Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D and Slack FJ: RAS is regulated by the let-7 microRNA family. Cell. 120:635–647. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S and Brabletz T: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9:582–589. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Hwang CI, Choi J, Zhou Z, Flesken-Nikitin A, Tarakhovsky A and Nikitin AY: MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF. Cell Cycle. 10:3834–3840. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Avraham R and Yarden Y: Regulation of signalling by microRNAs. Biochem Soc Trans. 40:26–30. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, Nakamura S, et al: The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Sci Rep. 5:84282015. View Article : Google Scholar : PubMed/NCBI

35 

He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, et al: A microRNA polycistron as a potential human oncogene. Nature. 435:828–833. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Garzon R, Marcucci G and Croce CM: Targeting microRNAs in cancer: Rationale, strategies and challenges. Nat Rev Drug Discov. 9:775–789. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Song S and Ajani JA: The role of microRNAs in cancers of the upper gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 10:109–118. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A and Mendell JT: Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 40:43–50. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, et al: Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 22:524–535. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Musilova K and Mraz M: MicroRNAs in B-cell lymphomas: How a complex biology gets more complex. Leukemia. 29:1004–1017. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Zhao X, Lwin T, Zhang X, Huang A, Wang J, Marquez VE, Chen-Kiang S, Dalton WS, Sotomayor E and Tao J: Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity. Leukemia. 27:2341–2350. 2013. View Article : Google Scholar : PubMed/NCBI

42 

O'Donnell KA, Wentzel EA, Zeller KI, Dang CV and Mendell JT: c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 435:839–843. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Ning Z, Wang A, Liang J, et al: USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells. Oncol Rep. 32:1451–1458. 2014.PubMed/NCBI

44 

Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A and Mendell JT: Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. Genes Dev. 24:2754–2759. 2010. View Article : Google Scholar : PubMed/NCBI

45 

El Baroudi M, Corà D, Bosia C, Osella M and Caselle M: A curated database of miRNA mediated feed-forward loops involving MYC as master regulator. PLoS One. 6:e147422011. View Article : Google Scholar : PubMed/NCBI

46 

Polioudakis D, Bhinge AA, Killion PJ, Lee BK, Abell NS and Iyer VR: A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes. Nucleic Acids Res. 41:2239–2254. 2013. View Article : Google Scholar : PubMed/NCBI

47 

He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, et al: A microRNA component of the p53 tumour suppressor network. Nature. 447:1130–1134. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Lin CJ, Cencic R, Mills JR, Robert F and Pelletier J: c-Myc and eIF4F are components of a feedforward loop that links transcription and translation. Cancer Res. 68:5326–5334. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Lin CJ, Malina A and Pelletier J: c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: Implications for anticancer therapy. Cancer Res. 69:7491–7494. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Cohen EE and Rosner MR: MicroRNA-regulated feed forward loop network. Cell Cycle. 8:2477–2478. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Cohen EE, Zhu H, Lingen MW, Martin LE, Kuo WL, Choi EA, Kocherginsky M, Parker JS, Chung CH and Rosner MR: A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res. 69:65–74. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Rokavec M, Wu W and Luo J-L: IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol Cell. 45:777–789. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Alexiou P, Maragkakis M, Papadopoulos GL, Reczko M and Hatzigeorgiou AG: Lost in translation: An assessment and perspective for computational microRNA target identification. Bioinformatics. 25:3049–3055. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Reyes-Herrera PH and Ficarra E: One decade of development and evolution of microRNA target prediction algorithms. Genomics Proteomics Bioinformatics. 10:254–263. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Mendes ND, Freitas AT and Sagot MF: Current tools for the identification of miRNA genes and their targets. Nucleic Acids Res. 37:2419–2433. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Nazarov PV, Reinsbach SE, Muller A, Nicot N, Philippidou D, Vallar L and Kreis S: Interplay of microRNAs, transcription factors and target genes: Linking dynamic expression changes to function. Nucleic Acids Res. 41:2817–2831. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Dubchak I, Munoz M, Poliakov A, Salomonis N, Minovitsky S, Bodmer R and Zambon AC: Whole-Genome rVISTA: A tool to determine enrichment of transcription factor binding sites in gene promoters from transcriptomic data. Bioinformatics. 29:2059–2061. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Krystkowiak I, Lenart J, Debski K, Kuterba P, Petas M, Kaminska B and Dabrowski M: Nencki Genomics Database - Ensembl funcgen enhanced with intersections, user data and genome-wide TFBS motifs. Database (Oxford). 2013:bat0692013. View Article : Google Scholar : PubMed/NCBI

59 

Jiang C, Xuan Z, Zhao F and Zhang MQ: TRED: A transcriptional regulatory element database, new entries and other development. Nucleic Acids Res. 35:(Database). D137–D140. 2007. View Article : Google Scholar : PubMed/NCBI

60 

Yamashita R, Sugano S, Suzuki Y and Nakai K: DBTSS: DataBase of Transcriptional Start Sites progress report in 2012. Nucleic Acids Res. 40:(D1). D150–D154. 2012. View Article : Google Scholar : PubMed/NCBI

61 

Kolchanov NA, Podkolodnaia OA, Anan'ko EA, Ignat'eva EV, Podkolodnyĭ NL, Merkulov VM, Stepanenko IL, Pozdniakov MA, Belova OE, Grigorovich DA, et al: Regulation of eukaryotic gene transcription: Description in the TRRD database. Mol Biol (Mosk). 35:934–942. 2001.(In Russian). PubMed/NCBI

62 

Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, Zeng T, Euskirchen G, Bernier B, Varhol R, Delaney A, et al: Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods. 4:651–657. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Perez-Pinera P, Ousterout DG, Brunger JM, Farin AM, Glass KA, Guilak F, Crawford GE, Hartemink AJ and Gersbach CA: Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods. 10:239–242. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Hesselberth JR, Chen X, Zhang Z, Sabo PJ, Sandstrom R, Reynolds AP, Thurman RE, Neph S, Kuehn MS, Noble WS, et al: Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods. 6:283–289. 2009. View Article : Google Scholar : PubMed/NCBI

65 

Hellman LM and Fried MG: Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc. 2:1849–1861. 2007. View Article : Google Scholar : PubMed/NCBI

66 

Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J, Cocito A and Amati B: Genomic targets of the human c-Myc protein. Genes Dev. 17:1115–1129. 2003. View Article : Google Scholar : PubMed/NCBI

67 

Wang J, Lu M, Qiu C and Cui Q: TransmiR: A transcription factor-microRNA regulation database. Nucleic Acids Res. 38:(Database). D119–D122. 2010. View Article : Google Scholar : PubMed/NCBI

68 

Yan Z, Shah PK, Amin SB, Samur MK, Huang N, Wang X, Misra V, Ji H, Gabuzda D and Li C: Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res. 40:e1352012. View Article : Google Scholar : PubMed/NCBI

69 

Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ and Pandolfi PP: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature. 465:1033–1038. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu Q, Qin H, Zhao Q and He XX: Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review). Biomed Rep 3: 611-616, 2015.
APA
Wu, Q., Qin, H., Zhao, Q., & He, X. (2015). Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review). Biomedical Reports, 3, 611-616. https://doi.org/10.3892/br.2015.477
MLA
Wu, Q., Qin, H., Zhao, Q., He, X."Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review)". Biomedical Reports 3.5 (2015): 611-616.
Chicago
Wu, Q., Qin, H., Zhao, Q., He, X."Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review)". Biomedical Reports 3, no. 5 (2015): 611-616. https://doi.org/10.3892/br.2015.477
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Q, Qin H, Zhao Q and He XX: Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review). Biomed Rep 3: 611-616, 2015.
APA
Wu, Q., Qin, H., Zhao, Q., & He, X. (2015). Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review). Biomedical Reports, 3, 611-616. https://doi.org/10.3892/br.2015.477
MLA
Wu, Q., Qin, H., Zhao, Q., He, X."Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review)". Biomedical Reports 3.5 (2015): 611-616.
Chicago
Wu, Q., Qin, H., Zhao, Q., He, X."Emerging role of transcription factor‑microRNA‑target gene feed‑forward loops in cancer (Review)". Biomedical Reports 3, no. 5 (2015): 611-616. https://doi.org/10.3892/br.2015.477
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team